자궁내막암종에서 cyclin E, CDK2, p27 발현에 관한 임상병리학적 연관성
The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
목적: 본 연구의 목적은 자궁내막암종에서 cyclin E, CDK2, p27 발현 양상을 관찰하여 자궁내막암종의 임상병리학적 인자들과 의 연관성을 평가하였다. 방법: 후향적 분석을 통하여, 1998년 1월부터 2006년 12월까지 자궁내막암종으로 자궁절제술을 시행받은 환자 71예를 분석하 였다. 면역조직화학적 염색을 하여 cyclin E, CDK2, p27 발현 양상을 살펴 보았다. 결과: 71예의 자궁내막암종 중에서 cyclin E, CDK2의 양성 발현은 각각 28예 (39.4%), 29예 (40.8%)에서 보였다. cyclin E 발현은 종양 세포의 림프절 전이 (P=0.033), 에스트로겐 수용체 발현 (P=0.003)과 통계학적으로 유의한 상관관계가 있었고, CDK2 발현은 에스트로겐 수용체 발현 (P=0.000)과 상관관계가 있었다. p27은 42예 (59.2%)에서 음성이었는데, 다른 임상병리학적 인자들과는 유의한 상관관계를 보이지 않았다. cyclin E 발현과 p27 소실을 보인 군에서는 진행된 병기 (P=0.002), 림프혈관 침범성 (P=0.030), 림프절 전이 (P=0.002)와 양의 상관관계를 보였다. 결론: Cyclin E 발현과 p27의 소실은 자궁내막암종의 나쁜 예후를 시사하는 인자로서 가능성을 보여 주었다.
참고문헌 (34)
- Jemal A, "Cancer statistics, 2006", CA Cancer J Clin, 56, pp.106~130 (2006)
- 대한산부인과학회부인종양위원회, "한국 부인암 등록사업 조사 보고서 (2004. 1. 1–2004. 12. 31)", 대한산부회지, 50, pp.28~78 (2007)
- Hartwell LH, "Twenty-five years of cell cycle genetics", Genetics, 129, pp.975~980 (1991)
- Nurse P, "Universal control mechanism regulating onset of M-phase", Nature, 344, pp.503~508 (1990)
- Hunter T, "Cyclins and cancer", Cell, 66, pp.1071~1074 (1991)
- Bártek J, "Molecular pathology of the cell cycle in human cancer cells", Stem Cells, 11, pp.51~58 (1993)
- Mumberg D, "Uncoupling of DNA replication and cell cycle progression by human cyclin E", Oncogene, 13, pp.2493~2497 (1996)
- Porter PL, "Expression of cell-cycle regulators P27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients", Nat Med, 3, pp.222~225 (1997)
- Keyomarsi K, "Cyclin E, a potential prognostic marker for breast cancer", Cancer Res, 54, pp.380~385 (1994)
- Kitahara K, "Concurrent amplification of cyclin E and CDK2 genes in colorectal carcinomas", Int J Cancer, 62, pp.25~28 (1995)
- Courjal F, "Cyclin gene amplification and overexpression in breast and ovarian cancers : evidence for the selection of cyclin D1 in breast and cyclin E in ovarian tumors", Int J Cancer, 69, pp.247~253 (1996)
- Marone M, "Analysis of cyclin E and Cdk2 in ovarian cancer: gene amplification and RNA overexpression", Int J Cancer, 75, pp.34~39 (1998)
- Sawasaki T, "Cyclin E mRNA overexpression in epithelial ovarian cancers : inverse-correlation with p53 protein accumulation", J Soc Gynecol Investig, 8, pp.179~185 (2001)
- Reynisdottir I, "Kip", Cip and Ink4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF–beta, 1995, pp.9, 1831~1845
- Wu J, "Prognostic role of p27Kip1 and apoptosis in human breast cancer", Br J Cancer, 79, pp.1572~1578 (1999)
- Sui L, "The concurrent expression of p27 (kip1) and cyclin D1 in epithelial ovarian tumors", Gynecol Oncol, 73, pp.202~209 (1999)
- Shigemasa K, "Underexpression of cyclin-dependent kinase inhibitor p27 is associated with poor prognosis in serous ovarian carcinomas", Int J Oncol, 18, pp.953~958 (2001)
- Mori M, "p27 expression and gastric carcinoma", Nat Med, 3, pp.593~ (1997)
- Loda M, "Increased proteasomedependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas", at Med, 3, pp.231~234 (1997)
- Guo Y, "Loss of the cyclin-dependent kinase inhibitor p27 (kip1) protein in human prostate cancer correlates with tumor grade", Clin Cancer Res, 3(12), pp.2269~2274 (1997)
- Bamberger AM, "Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia", Virchows Arch, 434, pp.423~428 (1999)
- Lukas J, "Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor cell lines", Oncogene, 9, pp.707~718 (1994)
- Hacker NF, "Uterine cancer. In: Practical gynecologic oncology", pp.397~442 (2005), Lippincott Williams & Wilkins
- Gong J, "Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines", Cancer Res, 54, pp.4285~4288 (1994)
- Hartwell LH, "Cell cycle control and cancer", Science, 266, pp.1821~1828 (1994)
- Cotran RS, "Robbins pathologic basis of disease", pp.282~292 (1999), Saunders
- Dosaka-Akita H, "A risk-s tratification model of non-small cell lung cancers using cyclin E, Ki-67, and ras p21 : different roles of G1 cyclins in cell proliferation and prognosis", Cancer Res, 61, pp.2500~2504 (2001)
- Li JQ, "Expression of cyclin E and cyclin-dependent kinase 2 correlates with metastasis and prognosis in colorectal carcinoma", Hum Pathol, 32, pp.945~953 (2001)
- Kato N, "Immunohistochemical expression of cyclin E in endometrial adenocarcinoma (endometrioid type) and its clinicopathological significance", J Cancer Res Clin Oncol, 129, pp.222~226 (2003)
- Mitselou A, "Expression of the cell-cycle regulatory proteins (cyclins D1 and E) in endometrial carcinomas: correlations with hormone receptor status, proliferating indices, tumor suppressor gene products (p53, pRb), and clinicopathological parameters", Eur J Gynaecol Oncol, 25, pp.719~724 (2004)
- Masciullo V, "Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 (Kip1) in estrogen-related Endometrial adenocarcinomas", Clin Cancer Res, 9, pp.5332~5338 (2003)
- Watanabe J, "Significance of p27 as a predicting marker for medroxyprogesterone acetate therapy against endometrial endometrioid adenocarcinoma", Int J Gynecol Cancer, 16, pp.452~457 (2006)
- Oshita T, "p27, cyclin E, and CDK2 expression in normal and cancerous endometrium", Int J Oncol, 21, pp.737~743 (2002)
- Kayaselcuk F, "Expression of cyclin H in normal and cancerous endometrium, its correlation with other cyclins, and association with clinicopathologic parameters", Int J Gynecol Cancer, 16, pp.402~408 (2006)
