만성 하기도 증상을 보이는 환자에서 진균 알레르기 검출을 위한 피부단자시험과 혈청 알레르겐-특이 IgE 검사 결과의 비교 분석
Skin Prick Tests and Allergen-specific IgE Tests for Fungus in Patients with Chronic Lower Respiratory Symptoms
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Background: Skin prick tests (SPTs) has relatively a good correlation with allergen-specific IgE against house dust mites and pollens, whereas their correlation to fungi remains low. Objective: We aimed to investigate the prevalence and correlation between fungus-specific IgE and SPTs in patients with chronic lower respiratory symptoms. The difference between fungus-specific IgE-positive and -negative groups was also examined. Method: A total of 566 patients were included in this study, all of whom had either negative SPT results, positive for one or more fungi, or positive for dusts or mixed threshings. Result: SPTs and allergen-specific IgE tests for fungus were positive in 9.4% and 11.8% of the patients, respec-ively. The positive concordance rate for fungus-specific IgE with SPTs was 47%. The k statistic for the agreement between SPTs and fungus-specific IgE test was 0.349. In all populations negative for SPTs, total eosinophil counts, total IgE, ECP and bronchial reversibility were higher in the fungus-specific IgE-positive group. In the group that tested only positive for dusts or mixed threshings with SPTs, total IgE and bronchial hyperresponsiveness were higher in the fungus-specific IgE-positive group (P＜.05). Conclusion: The rate of successful detection of fungus using SPTs was low compared to a fungus-specific IgE. Thus, fungus-specific IgE may be useful to detect fungus allergies in patients with chronic lower respiratory symptoms.
Abstract
Background: Skin prick tests (SPTs) has relatively a good correlation with allergen-specific IgE against house dust mites and pollens, whereas their correlation to fungi remains low. Objective: We aimed to investigate the prevalence and correlation between fungus-specific IgE and SPTs in patients with chronic lower respiratory symptoms. The difference between fungus-specific IgE-positive and -negative groups was also examined. Method: A total of 566 patients were included in this study, all of whom had either negative SPT results, positive for one or more fungi, or positive for dusts or mixed threshings. Result: SPTs and allergen-specific IgE tests for fungus were positive in 9.4% and 11.8% of the patients, respec-ively. The positive concordance rate for fungus-specific IgE with SPTs was 47%. The k statistic for the agreement between SPTs and fungus-specific IgE test was 0.349. In all populations negative for SPTs, total eosinophil counts, total IgE, ECP and bronchial reversibility were higher in the fungus-specific IgE-positive group. In the group that tested only positive for dusts or mixed threshings with SPTs, total IgE and bronchial hyperresponsiveness were higher in the fungus-specific IgE-positive group (P＜.05). Conclusion: The rate of successful detection of fungus using SPTs was low compared to a fungus-specific IgE. Thus, fungus-specific IgE may be useful to detect fungus allergies in patients with chronic lower respiratory symptoms.
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