Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome: A Bridge between Functional Organic Dichotomy
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The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO. Although quantitative jejunal aspirate culture is considered the gold standard for the diagnosis of SIBO, noninvasive hydrogen breath tests have been popular. Although the glucose hydrogen breath test is highly specific, its sensitivity is low; in contrast, the early-peak criteria in the lactulose hydrogen breath test are highly nonspecific. Female gender, older age, diarrhea-predominant IBS, bloating and flatulence, proton pump inhibitor and narcotic intake, and low hemoglobin are associated with SIBO among IBS patients. Several therapeutic trials targeting gut microbes using antibiotics and probiotics have further demonstrated that not all symptoms in patients with IBS originate in the brain but rather in the gut, providing support for the micro-organic basis of IBS. A recent proof-of-concept study showing the high frequency of symptom improvement in patients with IBS with SIBO further supports this hypothesis.
Abstract
The pathogenesis of irritable bowel syndrome (IBS), once thought to be largely psychogenic in origin, is now understood to be multifactorial. One of the reasons for this paradigm shift is the realization that gut dysbiosis, including small intestinal bacterial overgrowth (SIBO), causes IBS symptoms. Between 4% and 78% of patients with IBS and 1% and 40% of controls have SIBO; such wide variations in prevalence might result from population differences, IBS diagnostic criteria, and, most importantly, methods to diagnose SIBO. Although quantitative jejunal aspirate culture is considered the gold standard for the diagnosis of SIBO, noninvasive hydrogen breath tests have been popular. Although the glucose hydrogen breath test is highly specific, its sensitivity is low; in contrast, the early-peak criteria in the lactulose hydrogen breath test are highly nonspecific. Female gender, older age, diarrhea-predominant IBS, bloating and flatulence, proton pump inhibitor and narcotic intake, and low hemoglobin are associated with SIBO among IBS patients. Several therapeutic trials targeting gut microbes using antibiotics and probiotics have further demonstrated that not all symptoms in patients with IBS originate in the brain but rather in the gut, providing support for the micro-organic basis of IBS. A recent proof-of-concept study showing the high frequency of symptom improvement in patients with IBS with SIBO further supports this hypothesis.
참고문헌 (143)
- Wall GC, "Irritable bowel syndrome: a concise review of current treatment concepts", World J Gastroenterol, 20, pp.8796~8806 (2014)
- Ghoshal UC, "The gut microbiota and irritable bowel syndrome: friend or foe", Int J Inflam, 2012 (2012)
- Malinen E, "Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome", World J Gastroenterol, 16, pp.4532~4540 (2010)
- Reddymasu SC, "Small intestinal bacterial overgrowth in irritable bowel syndrome: are there any predictors", BMC Gastroenterol, 10, pp.23~ (2010)
- Lin HC, "Small intestinal bacterial overgrowth: a framework for understanding irritable bowel syndrome", JAMA, 292, pp.852~858 (2004)
- Dukowicz AC, "Small intestinal bacterial overgrowth: a comprehensive review", Gastroenterol Hepatol (N Y), 3, pp.112~122 (2007)
- Ghoshal UC, "Irritable bowel syndrome and small intestinal bacterial overgrowth: meaningful association or unnecessary hype", World J Gastroenterol, 20, pp.2482~2491 (2014)
- Grover M, "Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress", Neurogastroenterol Motil, 20, pp.998~1008 (2008)
- Levenstein S, "Psychological stress increases risk for peptic ulcer, regardless of Helicobacter pylori infection or use of nonsteroidal anti-inflammatory drugs", Clin Gastroenterol Hepatol, 13, pp.498~506.e1 (2015)
- Safavi M, "Treatment of Helicobacter pylori infection: current and future insights", World J Clin Cases, 4, pp.5~19 (2016)
- Wang L, "CagA promotes proliferation and secretion of extracellular matrix by inhibiting signaling pathway of apoptosis in rat glomerular mesangial cells", Ren Fail, 38, pp.458~464 (2016)
- Gerritsen J, "Intestinal microbiota in human health and disease: the impact of probiotics", Genes Nutr, 6, pp.209~240 (2011)
- Sekirov I, "Gut microbiota in health and disease", Physiol Rev, 90, pp.859~904 (2010)
- Ghoshal UC, "Bugs and irritable bowel syndrome:the good, the bad and the ugly", J Gastroenterol Hepatol, 25, pp.244~251 (2010)
- Lagier JC, "Human gut microbiota: repertoire and variations", Front Cell Infect Microbiol, 2, pp.136~ (2012)
- Nigam D, "Microbial interactions with humans and animals", Int J Microbiol Allied Sci, 2, pp.1~17 (2015)
- Eckburg PB, "Diversity of the human intestinal microbial flora", Science, 308, pp.1635~1638 (2005)
- Schloss PD, "Status of the microbial census", Microbiol Mol Biol Rev, 68, pp.686~691 (2004)
- O’Hara AM, "The gut flora as a forgotten organ", EMBO Rep, 7, pp.688~693 (2006)
- Vyas U, "Probiotics, prebiotics, and synbiotics:gut and beyond", Gastroenterol Res Pract, 2012, pp.872716~ (2012)
- Goulet O, "Intestinal microbiota in short bowel syndrome", Gastroenterol Clin Biol, 34(Suppl 1), pp.S37~S43 (2010)
- Bures J, "Small intestinal bacterial overgrowth syndrome", World J Gastroenterol, 16, pp.2978~2990 (2010)
- Vanderhoof JA, "Clinical manifestations and diagnosis of bacterial overgrowth: treatment of bacterial overgrowth", UpToDate Online, 18 (2010)
- Gabrielli M, "Diagnosis of small intestinal bacterial overgrowth in the clinical practice", Eur Rev Med Pharmacol Sci, 17(Suppl 2), pp.30~35 (2013)
- Hao WL, "Microflora of the gastrointestinal tract: a review", Methods Mol Biol, 268, pp.491~502 (2004)
- Riordan SM, "Small intestinal mucosal immunity and morphometry in luminal overgrowth of indigenous gut flora", Am J Gastroenterol, 96, pp.494~500 (2001)
- Erdogan A, "Small intestinal bacterial overgrowth: duodenal aspiration vs glucose breath test", Neurogastroenterol Motil, 27, pp.481~489 (2015)
- William D. Chey, "Pharmacologic and Complementary and Alternative Medicine Therapies for Irritable Bowel Syndrome", Gut and Liver, 5(3), pp.253~266 (2011), 거트앤리버 발행위원회
- Peralta S, "Small intestine bacterial overgrowth and irritable bowel syndrome-related symptoms: experience with rifaximin", World J Gastroenterol, 15, pp.2628~2631 (2009)
- Ziegler TR, "Small bowel bacterial overgrowth in adults:a potential contributor to intestinal failure", Curr Gastroenterol Rep, 9, pp.463~467 (2007)
- Ghoshal UC, "Utility of hydrogen breath tests in diagnosis of small intestinal bacterial overgrowth in malabsorption syndrome and its relationship with oro-cecal transit time", Indian J Gastroenterol, 25, pp.6~10 (2006)
- Britton E, "Ageing and the gut", Proc Nutr Soc, 72, pp.173~177 (2013)
- Ghoshal U, "Spectrum and antibiotic sensitivity of bacteria contaminating the upper gut in patients with malabsorption syndrome from the tropics", BMC Gastroenterol, 3, pp.987~ (2003)
- Lagier JC, "Microbial culturomics:paradigm shift in the human gut microbiome study", Clin Microbiol Infect, 18, pp.1185~1193 (2012)
- Kokcha S, "Non contiguous-finished genome sequence and description of Bacillus timonensis sp. nov", Stand Genomic Sci, 6, pp.346~355 (2012)
- Uday C Ghoshal, "How to Interpret Hydrogen Breath Tests", Journal of Neurogastroenterology and Motility (JNM), 17(3), pp.312~317 (2011), 대한소화기 기능성질환∙운동학회
- Nucera G, "Abnormal breath tests to lactose, fructose and sorbitol in irritable bowel syndrome may be explained by small intestinal bacterial overgrowth", Aliment Pharmacol Ther, 21, pp.1391~1395 (2005)
- Abraczinskas D, "Intestinal gas and bloating", Up-ToDate Online, 18 (2010)
- Ghoshal UC, "Breath tests in the diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome in comparison with quantitative upper gut aspirate culture", Eur J Gastroenterol Hepatol, 26, pp.753~760 (2014)
- Pimentel M, "Eradication of small intestinal bacterial overgrowth reduces symptoms of irritable bowel syndrome", Am J Gastroenterol, 95, pp.3503~3506 (2000)
- Kerlin P, "Breath hydrogen testing in bacterial overgrowth of the small intestine", Gastroenterology, 95, pp.982~988 (1988)
- Shah ED, "Abnormal breath testing in IBS: a meta-analysis", Dig Dis Sci, 55, pp.2441~2449 (2010)
- Simrén M, "Use and abuse of hydrogen breath tests", Gut, 55, pp.297~303 (2006)
- Ojetti V, "Early peak of hydrogen during lactose breath test predicts intestinal motility", Open J Gastroenterol, 4, pp.40~44 (2014)
- Yu D, "Combined oro-caecal scintigraphy and lactulose hydrogen breath testing demonstrate that breath testing detects oro-caecal transit, not small intestinal bacterial overgrowth in patients with IBS", Gut, 60, pp.334~340 (2011)
- xylose breath tests in patients with ileoanal anastomosis, "Int J Colorectal Dis", 1991, 208~211
- Banik GD, "Diagnosis of small intestinal bacterial overgrowth in irritable bowel syndrome patients using high-precision stable 13 CO 2", 12 CO 2 isotope ratios in exhaled breath, 2014, pp.29, 1918~1924
- Ghoshal UC, "Tropical sprue is associated with contamination of small bowel with aerobic bacteria and reversible prolongation of orocecal transit time", J Gastroen terol Hepatol, 18, pp.540~547 (2003)
- Lu CL, "Characteristics of small bowel motility in patients with irritable bowel syndrome and normal humans: an Oriental study", Clin Sci (Lond), 95, pp.165~169 (1998)
- Moraru IG, "Small intestinal bacterial overgrowth produces symptoms in irritable bowel syndrome which are improved by rifaximin: a pilot study", Rom J Intern Med, 51, pp.143~147 (2013)
- Uday C. Ghoshal, "Frequency of Small Intestinal Bacterial Overgrowth in Patients with Irritable Bowel Syndrome and Chronic Non-Specific Diarrhea", Journal of Neurogastroenterology and Motility (JNM), 16(1), pp.40~46 (2010), 대한소화기 기능성질환∙운동학회
- Posserud I, "Small intestinal bacterial overgrowth in patients with irritable bowel syndrome", Gut, 56, pp.802~808 (2007)
- Kerckhoffs AP, "Critical evaluation of diagnosing bacterial overgrowth in the proximal small intestine", J Clin Gastroenterol, 42, pp.1095~1102 (2008)
- Pyleris E, "The prevalence of overgrowth by aerobic bacteria in the small intestine by small bowel culture:relationship with irritable bowel syndrome", Dig Dis Sci, 57, pp.1321~1329 (2012)
- Walters B, "Detection of bacterial overgrowth in IBS using the lactulose H2 breath test: comparison with 14C-D-xylose and healthy controls", Am J Gastroenterol, 100, pp.1566~1570 (2005)
- Zhao J, "A study of the methodological and clinical validity of the combined lactulose hydrogen breath test with scintigraphic oro-cecal transit test for diagnosing small intestinal bacterial overgrowth in IBS patients", Neurogastroenterol Motil, 26, pp.794~802 (2014)
- 박정수, "과민성 장 증후군에서 소장세균과다증식의 예측을 위한 락툴로오스 호기검사의 유용성", 대한소화기학회지, 56(4), pp.242~248 (2010), 대한소화기학회
- Scarpellini E, "Prevalence of small intestinal bacterial overgrowth in children with irritable bowel syndrome: a case-control study", J Pediatr, 155, pp.416~420 (2009)
- Carrara M, "Small intestine bacterial overgrowth in patients with irritable bowel syndrome", Eur Rev Med Pharmacol Sci, 12, pp.197~202 (2008)
- Mann NS, "The prevalence of small intestinal bacterial overgrowth in irritable bowel syndrome", Hepatogastroenterology, 56, pp.718~721 (2009)
- Rana SV, "Study of small intestinal bacterial overgrowth in North Indian patients with irritable bowel syndrome: a case control study", Trop Gastroenterol, 29, pp.23~25 (2008)
- Yakoob J, "Small intestinal bacterial overgrowth and lactose intolerance contribute to irritable bowel syndrome symptomatology in Pakistan", Saudi J Gastroenterol, 17, pp.371~375 (2011)
- Majewski M, "Results of small intestinal bacterial overgrowth testing in irritable bowel syndrome patients: clinical profiles and effects of antibiotic trial", Adv Med Sci, 52, pp.139~142 (2007)
- Sachdeva S, "Small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome: frequency and predictors", J Gastroenterol Hepatol, 26(Suppl 3), pp.135~138 (2011)
- Cuoco L, "Small intestine bacterial overgrowth in irritable bowel syndrome: a retrospective study with rifaximin", Minerva Gastroenterol Dietol, 52, pp.89~95 (2006)
- Lupascu A, "Hydrogen glucose breath test to detect small intestinal bacterial overgrowth: a prevalence case-control study in irritable bowel syndrome", Aliment Pharmacol Ther, 22, pp.1157~1160 (2005)
- Rana SV, "Comparison of lactulose and glucose breath test for diagnosis of small intestinal bacterial overgrowth in patients with irritable bowel syndrome", Digestion, 85, pp.243~247 (2012)
- Abbasi MH, "Small bowel bacterial overgrowth in patients with irritable bowel syndrome: the first study in iran", Middle East J Dig Dis, 7, pp.36~40 (2015)
- Ford AC, "Small intestinal bacterial overgrowth in irritable bowel syndrome: systematic review and meta-analysis", Clin Gastroenterol Hepatol, 7, pp.1279~1286 (2009)
- Moraru IG, "Small intestinal bacterial overgrowth is associated to symptoms in irritable bowel syndrome: evidence from a multicentre study in Romania", Rom J Intern Med, 52, pp.143~150 (2014)
- Singh VV, "Small bowel bacterial overgrowth: presentation, diagnosis, and treatment", Curr Treat Options Gastroenterol, 7, pp.19~28 (2004)
- Vandeputte D, "Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates", Gut, 65, pp.57~62 (2016)
- Spiegel BM, "Bacterial overgrowth and irritable bowel syndrome: unifying hypothesis or a spurious consequence of proton pump inhibitors", Am J Gastroenterol, 103, pp.2972~2976 (2008)
- Choung RS, "Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture", Aliment Pharmacol Ther, 33, pp.1059~1067 (2011)
- Gasbarrini A, "Clinical predictors of small intestinal bacterial overgrowth by duodenal aspirate culture", Aliment Pharmacol Ther, 33, pp.1378~1379 (2011)
- Haderstorfer B, "Intestinal gas production from bacterial fermentation of undigested carbohydrate in irritable bowel syndrome", Am J Gastroenterol, 84, pp.375~378 (1989)
- Sachdev AH, "Gastrointestinal bacterial overgrowth:pathogenesis and clinical significance", Ther Adv Chronic Dis, 4, pp.223~231 (2013)
- Shukla R, "Fecal microbiota in patients with irritable bowel syndrome compared with healthy controls using real-time polymerase chain reaction: an evidence of dysbiosis", Dig Dis Sci, 60, pp.2953~2962 (2015)
- 박효진, "The Role of Small Intestinal Bacterial Overgrowth in the Pathophysiology of Irritable Bowel Syndrome", Journal of Neurogastroenterology and Motility (JNM), 16(1), pp.3~4 (2010), 대한소화기 기능성질환∙운동학회
- 최창환, "Role of Small Intestinal Bacterial Overgrowth in Functional Gastrointestinal Disorders", Journal of Neurogastroenterology and Motility (JNM), 22(1), pp.3~5 (2016), 대한소화기 기능성질환∙운동학회[DOI]
- Barbara G, "The intestinal microenvironment and functional gastrointestinal disorders", Gastroenterology, 150, pp.1305~1318.e8 (2016)
- Francisconi CF, "Multicultural aspects in functional gastrointestinal disorders (FGIDs)", Gastroenterology, 150, pp.1344~1354 (2016)
- Lacy BE, "Bowel disorders", Gastroenterology, 150, pp.1393~1407 (2016)
- Pimentel M, "Methanogens in human health and disease", Am J Gastroenterol, 1, pp.28~33 (2012)
- Fan X, "Review article: small intestinal bacterial overgrowth, bile acid malabsorption and gluten intolerance as possible causes of chronic watery diarrhoea", Aliment Pharmacol Ther, 29, pp.1069~1077 (2009)
- Riepe SP, "Effect of secreted Bacteroides proteases on human intestinal brush border hydrolases", J Clin Invest, 66, pp.314~322 (1980)
- Zaidel O, "Uninvited guests: the impact of small intestinal bacterial overgrowth on nutritional status", Pract Gastroenterol, 27, pp.27~34 (2003)
- Bala L, "Malabsorption syndrome with and without small intestinal bacterial overgrowth: a study on upper-gut aspirate using 1H NMR spectroscopy", Magn Reson Med, 56, pp.738~744 (2006)
- Ghoshal UC, "Pathogenesis of tropical sprue: a pilot study of antroduodenal manometry, duodenocaecal transit time & fat-induced ileal brake", Indian J Med Res, 13, pp.63~72 (2013)
- Donowitz JR, "Pediatric small intestine bacterial overgrowth in low-income countries", Trends Mol Med, 21, pp.6~15 (2015)
- Rhee SH, "Principles and clinical implications of the brain-gut-enteric microbiota axis", Nat Rev Gastroenterol Hepatol, 6, pp.306~314 (2009)
- Malbert CH, "The ileocolonic sphincter", Neurogastroenterol Motil, 17(Suppl 1), pp.41~49 (2005)
- Dass NB, "The relationship between the effects of short-chain fatty acids on intestinal motility in vitro and GPR43 receptor activation", Neurogastroenterol Motil, 19, pp.66~74 (2007)
- Barbara G, "Interactions between commensal bacteria and gut sensorimotor function in health and disease", Am J Gastroenterol, 100, pp.2560~2568 (2005)
- Dibaise JK, "Enteric microbial flora, bacterial overgrowth, and short-bowel syndrome", Clin Gastroenterol Hepatol, 4, pp.11~20 (2006)
- Srivastava D, "Associations between IL-1RA polymorphisms and small intestinal bacterial overgrowth among patients with irritable bowel syndrome from India", Neurogastroenterol Motil, 26, pp.1408~1416 (2014)
- Rana SV, "Pro-inflammatory and anti-inflammatory cytokine response in diarrhoea-predominant irritable bowel syndrome patients", Trop Gastroenterol, 33, pp.251~256 (2012)
- Spinucci G, "Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth", Eur J Gastroenterol Hepatol, 18, pp.799~802 (2006)
- Schmulson M, "Microbiota, gastrointestinal infections, low-grade inflammation, and antibiotic therapy in irritable bowel syndrome: an evidence-based review", Rev Gastroenterol Mex, 79, pp.96~134 (2014)
- Ford AC, "Mucosal inflammation as a potential etiological factor in irritable bowel syndrome: a systematic review", J Gastroenterol, 46, pp.421~431 (2011)
- Hasler WL, "Traditional thoughts on the pathophysiology of irritable bowel syndrome", Gastroenterol Clin North Am, 40, pp.21~43 (2011)
- Patacchini R, "Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle", Eur J Pharmacol, 509, pp.171~177 (2005)
- Weinstock LB, "Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms", Dig Dis Sci, 53, pp.1246~1251 (2008)
- Banik GD, "Hydrogen sulphide in exhaled breath: a potential biomarker for small intestinal bacterial overgrowth in IBS", J Breath Res, 10, pp.026010~ (2016)
- Pimentel M, "A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing", Ann Rheum Dis, 63, pp.450~452 (2004)
- 권중구, "과민성 장증후군 치료에 관한 임상진료지침", 대한소화기학회지, 57(2), pp.82~99 (2011), 대한소화기학회
- Neale G, "The metabolic and nutritional consequences of bacterial overgrowth in the small intestine", Am J Clin Nutr, 25, pp.1409~1417 (1972)
- Scarpellini E, "High dosage rifaximin for the treatment of small intestinal bacterial overgrowth", Aliment Pharmacol Ther, 25, pp.781~786 (2007)
- Di Stefano M, "Treatment of small intestine bacterial overgrowth", Eur Rev Med Pharmacol Sci, 9, pp.217~222 (2005)
- Quigley EM, "Small intestinal bacterial overgrowth:roles of antibiotics, prebiotics, and probiotics", Gastroenterology, 130(2 Suppl1), pp.S78~S90 (2006)
- Chedid V, "Herbal therapy is equivalent to rifaximin for the treatment of small intestinal bacterial overgrowth", Glob Adv Health Med, 3, pp.16~24 (2014)
- Lauritano EC, "Rifaximin dosefinding study for the treatment of small intestinal bacterial overgrowth", Aliment Pharmacol Ther, 22, pp.31~35 (2005)
- Pimentel M, "Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome: a double-blind, randomized, placebo-controlled study", Am J Gastroenterol, 98, pp.412~419 (2003)
- Ghoshal UC, "A proof-ofconcept study showing antibiotics to be more effective in irritable bowel syndrome with than without small-intestinal bacterial overgrowth: a randomized, double-blind, placebo-controlled trial", Eur J Gastroenterol Hepatol, 28, pp.281~289 (2016)
- Pimentel M, "Rifaximin therapy for patients with irritable bowel syndrome without constipation", N Engl J Med, 364, pp.22~32 (2011)
- Ford AC, "American College of Gastroenterology monograph on the management of irritable bowel syndrome and chronic idiopathic constipation", Am J Gastroenterol, 109(Suppl 1), pp.S2~S26 (2014)
- Lacy BE, "New and emerging treatment options for irritable bowel syndrome", Gastroenterol Hepatol (N Y), 11(4 Suppl 2), pp.1~19 (2015)
- Weinberg DS, "American Gastroenterological Association. American Gastroenterological Association Institute Guideline on the pharmacological management of irritable bowel syndrome", Gastroenterology, 147, pp.1146~1148 (2014)
- Attar A, "Antibiotic efficacy in small intestinal bacterial overgrowth-related chronic diarrhea: a crossover, randomized trial", Gastroenterology, 117, pp.794~797 (1999)
- Gatta L, "Mo2055 Rifaximin for treatment of small intestine bacterial overgrowth (SIBO): a systematic review and meta-analysis", Gastroenterology, 144(5 Suppl 1), pp.S729~ (2013)
- Shah SC, "Meta-analysis: antibiotic therapy for small intestinal bacterial overgrowth", Aliment Pharmacol Ther, 38, pp.925~934 (2013)
- 이범재, "Irritable Bowel Syndrome, Gut Microbiota and Probiotics", Journal of Neurogastroenterology and Motility (JNM), 17(3), pp.252~266 (2011), 대한소화기 기능성질환∙운동학회
- Lacy BE, "The treatment of irritable bowel syndrome", Therap Adv Gastroenterol, 2, pp.221~238 (2009)
- O’Mahony L, "Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles", Gastroenterology, 128, pp.541~551 (2005)
- Thijssen AY, "Effect of probiotic treatment on visceral hypersensitivity in irritable bowel syndrome", Gastroenterology, 140(5 Suppl 1), pp.S852~ (2011)
- Lyszkowska M, "Probiotics in children with gut failure", J Pediatr Gastroenterol Nutr, 46, pp.543~ (2008)
- Rosania R, "Effect of probiotic or prebiotic supplementation on antibiotic therapy in the small intestinal bacterial overgrowth: a comparative evaluation", Curr Clin Pharmacol, 8, pp.169~172 (2013)
- Kim HJ, "A randomized controlled trial of a probiotic, VSL#3, on gut transit and symptoms in diarrhoea-predominant irritable bowel syndrome", Aliment Pharmacol Ther, 17, pp.895~904 (2003)
- Kim HJ, "A randomized controlled trial of a probiotic combination VSL# 3 and placebo in irritable bowel syndrome with bloating", Neurogastroenterol Motil, 17, pp.687~696 (2005)
- Pimentel M, "Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth", Dig Dis Sci, 47, pp.2639~2643 (2002)
- Pimentel M, "Low-dose nocturnal tegaserod or erythromycin delays symptom recurrence after treatment of irritable bowel syndrome based on presumed bacterial overgrowth", Gastroenterol Hepatol (N Y), 5, pp.435~442 (2009)
- Shepherd SJ, "The role of FODMAPs in irritable bowel syndrome", Curr Opin Clin Nutr Metab Care, 17, pp.605~609 (2014)
- Halmos EP, "A diet low in FODMAPs reduces symptoms of irritable bowel syndrome", Gastroenterology, 146, pp.67~75.e5 (2014)
- Barrett JS, "Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals", Therap Adv Gastroenterol, 5, pp.261~268 (2012)
- Hayes PA, "Irritable bowel syndrome:the role of food in pathogenesis and management", Gastroenterol Hepatol (N Y), 10, pp.164~174 (2014)
- Ong DK, "Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome", J Gastroenterol Hepatol, 25, pp.1366~1373 (2010)
- Turnbaugh PJ, "The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice", Sci Transl Med, 1, pp.6~14 (2009)
- Brown K, "Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease", Nutrients, 4, pp.1095~1119 (2012)
- Zimmer J, "A vegan or vegetarian diet substantially alters the human colonic faecal microbiota", Eur J Clin Nutr, 66, pp.53~60 (2012)
- Uday C Ghoshal, "Frequency and risk factors of functional gastro-intestinal disorders in a rural Indian population", Journal of Gastroenterology and Hepatology, 32(2), pp.378~387 (2017), Wiley-Blackwell[DOI]
- Drossman DA, "Multi-dimensional clinical profile (MDCP): for functional gastrointestinal disorders", pp.7~14 (2015), Rome Foundation
- Lindberg DA, "Hydrogen breath testing in adults: what is it and why is it performed", Gastroenterol Nurs, 32, pp.19~24 (2009)
- Lombardo L, "Increased incidence of small intestinal bacterial overgrowth during proton pump inhibitor therapy", Clin Gastroenterol Hepatol, 8, pp.504~508 (2010)
