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Clinical Aspects and Treatments for Pediatric Inflammatory Bowel Diseases

Jin Soo Moon
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)|2019.01|Pediatric Gastroenterology, Hepatology & Nutrition|제22권 제1호|pp. 50-56|DOI 10.5223/pghn.2019.22.1.50

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.Ulcerative colitisPediatricsInflammatory bowel diseasesCrohn diseaseAnti-tumor necrosis factor-α blockers
주제분류소아과학

초록

The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Newer drugs such as anti-tumor necrosis factor α have been known to make a difference in treating pediatric IBD. Recent studies suggested that the patients with high risk factors might have some benefits from earlier use of biologics. To achieve treatment goals such as relieving symptoms, optimizing growth, and improving quality of life while minimizing drug toxicity, more research is needed to develop tools for risk stratification in the use of biologics for pediatric IBD.

Abstract

The incidence of pediatric inflammatory bowel disease (IBD) is increasing worldwide, especially in the developing countries. It differs from adult disease in clinical manifestations, especially with regard to genetic predisposition in monogenic IBD. Pediatric disease also have a tendency to show more aggressive inflammation and greater extent of lesion. Newer drugs such as anti-tumor necrosis factor α have been known to make a difference in treating pediatric IBD. Recent studies suggested that the patients with high risk factors might have some benefits from earlier use of biologics. To achieve treatment goals such as relieving symptoms, optimizing growth, and improving quality of life while minimizing drug toxicity, more research is needed to develop tools for risk stratification in the use of biologics for pediatric IBD.

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관련 논문AI추천

Biological Therapy for Inflammatory Bowel Disease in Children나소영, Jung Ok Shim대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2012 · 제15권 제1호Early Biologic Treatment in Pediatric Crohn’s Disease: Catchingthe Therapeutic Window of Opportunity in Early Disease by Treat-to-TargetBen Kang, Yon Ho Choe대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2018 · 제21권 제1호Higher Morbidity of Monogenic Inflammatory Bowel Disease Compared to the Adolescent Onset Inflammatory Bowel Disease문진수, Eun Joo Lee, Hye Ran Yang, Jae Sung Ko, Ju Whi Kim, Ju Young Jang, Kwang Yeon Kim대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2018 · 제21권 제1호Recent Advance in Very Early Onset Inflammatory Bowel DiseaseJung Ok Shim대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2019 · 제22권 제1호Efficacy of Early Infliximab Treatment for Pediatric Crohn’s Disease: A Three-year Follow-up김미진, 이유민, Sang Hun Baek, Yon Ho Choe, Yoon Lee, Yun Seok Lee대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2012 · 제15권 제4호Short-Term Outcome of Infliximab Therapy in Pediatric Crohn’s Disease: A Single-Center Experience김경모, 오석희, 이성희, 정인숙, Dai Jung대한소아소화기영양학회 · Pediatric Gastroenterology, Hepatology & Nutrition2017 · 제20권 제4호

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