논문KCI 등재
A Novel e8a2BCR-ABL1 Fusion Transcript without Insertion Sequence in a Patient with Chronic Myeloid Leukemia
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초록
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the formation of a Philadelphia (Ph) chromosome. Most chimeric BCR-ABL1 fusion transcripts are e13a2(b2a2) or e14a2(b3a2), encoding a 210-kDa protein, p210, but some are a e1a2 transcript or e19a2 transcript encoding a 190-kDa protein or a 230-kDa protein, respectively [1]
Abstract
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22, resulting in the formation of a Philadelphia (Ph) chromosome. Most chimeric BCR-ABL1 fusion transcripts are e13a2(b2a2) or e14a2(b3a2), encoding a 210-kDa protein, p210, but some are a e1a2 transcript or e19a2 transcript encoding a 190-kDa protein or a 230-kDa protein, respectively [1]
참고문헌 (10)
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관련 논문AI추천
Concurrence of e1a2 and e19a2 BCR-ABL1 Fusion Transcripts in a Typical Case of Chronic Myeloid Leukemia김달식, 이재현, 이혜수, 조용곤, 최삼임대한진단검사의학회 · Annals of Laboratory Medicine2017 · 제37권 제1호A Case of Chronic Myeloid Leukemia with Micro BCR::ABL1 Rearrangement: Precaution in Reverse Transcription PCR to Prevent False Negativity김서완, 김홍경, 신새암, 정해림대한진단검사의학회 · Laboratory Medicine Online2023 · 제13권 제4호A Case of Chronic Myeloid Leukemia With Rare Variant ETV6/ABL1 Rearrangement신희봉, 이용화, 이유경, 장미애, 전병렬, 정우준, 최수인, 홍대식대한진단검사의학회 · Annals of Laboratory Medicine2017 · 제37권 제1호Four Cases of Chronic Myelogenous Leukemia in Mixed Phenotype Blast Phase at Initial Presentation Mimicking Mixed Phenotype Acute Leukemia with t(9;22)이석, 김명신, 김용구, 이재욱, 임지향, 정낙균, 최우진, 한경자대한진단검사의학회 · Annals of Laboratory Medicine2014 · 제34권 제1호A Case with Coexistence of Major and Minor BCR/ABL Fusion Transcript at Lymphoblastic Crisis of Chronic Myelogenous Leukemia in Patients with Major BCR/ ABL Positivity during Chronic Phase박상혁, 박찬정, 임호준, 장성수, 조영욱, 지현숙대한진단검사의학회 · Annals of Laboratory Medicine2013 · 제33권 제1호e8a2 BCR::ABL1 재조합 만성골수백혈병에서 Out-of-frame 및 In-frame 전사물이 함께 검출된 증례Choi Jong Rak, Kim Jin Ju, Lee Jinho, Lee Seung-Tae, Shin Saeam대한진단검사의학회 · Laboratory Medicine Online2025 · 제15권 제4호
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