白芷의 α-Melanocyte Stimulating Hormone에 의해 유도된 B16 흑색종 세포의 멜라닌 형성에 미치는 영향
Effects of Aqueous Extracts from Angelica dahurica Benth. on α-Melanocyte Stimulating Hormone-induced Melanogenesis inse Melanoma Cell.
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Abstract
Melanin determines phenotypic appearance and its electron-opaque property protects cells from physical, including ultraviolet (UV) radiation, and chemical stimuli such as free radicals. However hyper-pigmentation is associated with various skin diseases such as keloid scar. The aim of present study was to investigate the effects of aqueous extracts from Angelica dahurica Benth. (AEAD) on α-Melanocyte stimulating hormone (α-MSH)-induced melanogenesis in B16 mouse melanoma cell. Relative high doses (5 ㎎/㎖) of AEAD could inhibit melanin formation without apoptotic death in cells treated with α-MSH. And also, α-MSH-induced activation of tyrosinase was inhibited in cells treated with AEAD. These results suggest that AEAD inhibit melanogenesis through inhibiting tyrosinase activity, and also, AEAD may apply to develop whitening drugs and cosmetics.