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Glioblastoma multiforme: a perspective on recent findings in human cancer and mouse models

Sang Kyun Lim|Sheila R. Alcantara Llaguno|Renée M. McKay|Luis F. Parada
생화학분자생물학회 (Korean Society Of Biochemistry And Molecular Biology)|2011.03|BMB Reports|제44권 제3호|pp. 158-164

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GliomaGlioblastomaGlioma stem cellsMouse models of glioma
주제분류화학

초록

Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed. [BMB reports 2011;44(3): 158-164]

Abstract

Gliomas are the most frequently occurring primary malignancies in the central nervous system, and glioblastoma multiforme (GBM) is the most common and most aggressive of these tumors. Despite vigorous basic and clinical studies over past decades, the median survival of patients with this disease remains at about one year. Recent studies have suggested that GBMs contain a subpopulation of tumor cells that displays stem cell characteristics and could therefore be responsible for in vivo tumor growth. We will summarize the major oncogenic pathways abnormally regulated in gliomas, and review the recent findings from mouse models that our laboratory as well as others have developed for the study of GBM. The concept of cancer stem cells in GBM and their potential therapeutic importance will also be discussed. [BMB reports 2011;44(3): 158-164]

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