응급실 내원 소아청소년에서 심한 식품알레르기의 발생 빈도와 임상 특징
Incidence and Clinical Characteristics of Pediatric Emergency Department Visits of Children with Severe Food Allergy
2
조회
0
다운로드
22
인용
0
참고문헌
키워드
초록
Background: Incidence and severity of childhood food allergy increased during the past 2 decades and that pediatric emergency department visits and death occurring due to food-induced anaphylaxis also increased in Western countries. Methods: To evaluate the incidence and clinical characteristics of pediatric emergency department visits due to severe forms of food allergy in Korea, data were collected from 305 with urticaria, angioedema or anaphylaxis of 78,889 children aged ≤18 or younger than 18 years who visited the emergency departments between of 9 hospitals in 8 cities in Korea June 2008 and March 2009. The incidence and clinical characteristics of childhood food allergy were evaluated using the detailed medical records. Results: Of 78,889 children, 169 (0.214%) showed food-related systemic urticaria, angioedema or anaphylaxis. Of the 57 children with anaphylaxis, 36 of which (63.16%) were food-related. The incidence of food-related anaphylaxis was 4.56 per 10,000 pediatric emergency department visits. Cutaneous symptoms (92.8%) were the most common anaphylaxis followed by cardiovascular (29.82%), gastrointestinal (28.07%), and respiratory symptoms (24.56%). The most common offending food allergen was fish, followed by cow's milk, other seafoods, chicken, pork, egg,walnut, pupa, peanut, beef and buckwheat. There were no cases of death from anaphylaxis in this study. Conclusion: This is the first study to evaluate the incidence of pediatric emergency department visits and severity of childhood food allergy in Korea. The causative food allergens and clinical characteristics of pediatric emergency department visits due to food allergy in Korean children have been surveyed.
Abstract
Background: Incidence and severity of childhood food allergy increased during the past 2 decades and that pediatric emergency department visits and death occurring due to food-induced anaphylaxis also increased in Western countries. Methods: To evaluate the incidence and clinical characteristics of pediatric emergency department visits due to severe forms of food allergy in Korea, data were collected from 305 with urticaria, angioedema or anaphylaxis of 78,889 children aged ≤18 or younger than 18 years who visited the emergency departments between of 9 hospitals in 8 cities in Korea June 2008 and March 2009. The incidence and clinical characteristics of childhood food allergy were evaluated using the detailed medical records. Results: Of 78,889 children, 169 (0.214%) showed food-related systemic urticaria, angioedema or anaphylaxis. Of the 57 children with anaphylaxis, 36 of which (63.16%) were food-related. The incidence of food-related anaphylaxis was 4.56 per 10,000 pediatric emergency department visits. Cutaneous symptoms (92.8%) were the most common anaphylaxis followed by cardiovascular (29.82%), gastrointestinal (28.07%), and respiratory symptoms (24.56%). The most common offending food allergen was fish, followed by cow's milk, other seafoods, chicken, pork, egg,walnut, pupa, peanut, beef and buckwheat. There were no cases of death from anaphylaxis in this study. Conclusion: This is the first study to evaluate the incidence of pediatric emergency department visits and severity of childhood food allergy in Korea. The causative food allergens and clinical characteristics of pediatric emergency department visits due to food allergy in Korean children have been surveyed.
참고문헌 (20)
- Gupta RS, "The prevalence, severity, and distribution of childhood food allergy in the United States", Pediatrics, 128, pp.e9~e17 (2011)
- Amin AJ, "Changes in prevalence and characteristics of IgE-mediated food allergies in children referred to a tertiary care center in 2003 and 2008", Allergy Asthma Proc, 33, pp.95~101 (2012)
- Bock SA, "Further fatalities caused by anaphylactic reactions to food, 2001-2006", J Allergy Clin Immunol, 119, pp.1016~1018 (2007)
- 홍수종, "한국 소아알레르기 질환의 유병률", Allergy Asthma & Respiratory Diseases, 18(1), pp.15~25 (2008), 대한 소아알레르기 호흡기학회
- Sheikh A, "Hospital admissions for acute anaphylaxis: time trend study", BMJ, 320, pp.1441~ (2000)
- Bohlke K, "Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization", J Allergy Clin Immunol, 113, pp.536~542 (2004)
- Koplin JJ, "An update on epidemiology of anaphylaxis in children and adults", Curr Opin Allergy Clin Immunol, 11, pp.492~496 (2011)
- Decker WW, "The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project", J Allergy Clin Immunol, 122, pp.1161~1165 (2008)
- 임대현, "소아청소년에서 아나필락시스의 역학", Korean Journal of Pediatrics, 51(4), pp.351~354 (2008), 대한소아과학회
- Liew WK, "Anaphylaxis fatalities and admissions in Australia", J Allergy Clin Immunol, 123, pp.434~442 (2009)
- Pumphrey R, "Anaphylaxis: can we tell who is at risk of a fatal reaction?", Curr Opin Allergy Clin Immunol, 4, pp.285~290 (2004)
- Bock SA, "Fatalities due to anaphylactic reactions to foods", J Allergy Clin Immunol, 107, pp.191~193 (2001)
- Sampson HA, "Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease", Food Allergy and Anaphylaxis Network symposium, 2006, pp.47, 373~380
- Wassenberg J, "Parent perceived quality of life is age-dependent in children with food allergy", Pediatr Allergy Immunol, 23, pp.412~419 (2012)
- Harduar-Morano L, "A population- based epidemiologic study of emergency department visits for anaphylaxis in Florida", J Allergy Clin Immunol, 128, pp.594~600 (2011)
- Arroabarren E, "Improving anaphylaxis management in a pediatric emergency department", Pediatr Allergy Immunol, 22, pp.708~714 (2011)
- Rudders SA, "Trends in pediatric emergency department visits for food-induced anaphylaxis", J Allergy Clin Immunol, 126, pp.385~388 (2010)
- Piromrat K, "Anaphylaxis in an emergency department: a 2-year study in a tertiary-care hospital", Asian Pac J Allergy Immunol, 26, pp.121~128 (2008)
- Braganza SC, "Paediatric emergency department anaphylaxis: different patterns from adults", Arch Dis Child, 91, pp.159~163 (2006)
- de Silva IL, "Paediatric anaphylaxis: a 5 year retrospective review", Allergy, 63, pp.1071~1076 (2008)