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외상 후 스트레스 장애 잔단 유무에 따른 고령의 재향 군인의 뇌백질 고신호 차이

Differences in White Matter Hyperintensity in Elderly Veterans With and Without Post-Traumatic Stress Disorder

최진희|최하연|이승훈|이은영|배희원
대한노인정신의학회 (Korean Association For Geriatric Psychiatry)|2023.04|노인정신의학 (Journal of Korean Geriatric Psychiatry)|제27권 제1호|pp. 16-22

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외상 후 스트레스 장애Post-traumatic stress disorderVeterans.White matter hyperintensity뇌백질 고신호재향 군인

초록

Objective: Exposure to stressful events is associated with the progression of white matter hyperintensity (WMH). The purpose of this study was to determine the difference in WMH depending on the presence of Post-traumatic stress disorder (PTSD). Methods: The patients who underwent brain magnetic resonance imaging and clinician-administered PTSD scale (CAPS) at the Veteran Health Service Medical Center were reviewed retrospectively. WMH were evaluated using the Fazekas scale. The patients with PTSD (n=51; age 66.25±10.43 years) were compared with patients exposed to trauma without PTSD (n=67; age 69.45±10.44 years). Results: The scores of Beck Depression Scale, Beck Anxiety scale, and CAPS were significantly higher in the PTSD group. The PTSD group showed a significant difference on the Fazekas scale compared to the trauma-exposed group without PTSD (periventricular white matter, p=0.001; deep white matter, p=0.008). After adjusting for age, smoking and comorbidity, WMH was higher in the PTSD group than in the trauma exposed group (periventricular white matter, p<0.001; deep white matter, p=0.006). Conclusion: The results suggests that there may be an association between PTSD and WMH as well as stressful events

Abstract

Objective: Exposure to stressful events is associated with the progression of white matter hyperintensity (WMH). The purpose of this study was to determine the difference in WMH depending on the presence of Post-traumatic stress disorder (PTSD). Methods: The patients who underwent brain magnetic resonance imaging and clinician-administered PTSD scale (CAPS) at the Veteran Health Service Medical Center were reviewed retrospectively. WMH were evaluated using the Fazekas scale. The patients with PTSD (n=51; age 66.25±10.43 years) were compared with patients exposed to trauma without PTSD (n=67; age 69.45±10.44 years). Results: The scores of Beck Depression Scale, Beck Anxiety scale, and CAPS were significantly higher in the PTSD group. The PTSD group showed a significant difference on the Fazekas scale compared to the trauma-exposed group without PTSD (periventricular white matter, p=0.001; deep white matter, p=0.008). After adjusting for age, smoking and comorbidity, WMH was higher in the PTSD group than in the trauma exposed group (periventricular white matter, p<0.001; deep white matter, p=0.006). Conclusion: The results suggests that there may be an association between PTSD and WMH as well as stressful events

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