Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background/Aims: Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms. Methods: Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers. Results: In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSIL], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987). Conclusions: The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.
Abstract
Background/Aims: Microsatellite instability (MSI) plays a crucial role in gastrointestinal carcinogenesis. The aim of this study was to clarify whether MSI is a useful marker for predicting synchronous gastric and colorectal neoplasms. Methods: Consecutive patients who underwent both esophagogastroduodenoscopy and colonoscopy before the resection of gastric or colorectal cancers were included. MSI was analyzed using two mononucleotide and three dinucleotide markers. Results: In total, 434 gastric cancers (372 microsatellite stability [MSS], 21 low incidence of MSI [MSIL], and 41 high incidence of MSI [MSI-H]) and 162 colorectal cancers (138 MSS, 9 MSI-L, and 15 MSI-H) were included. Patients with MSI gastric cancer had a higher prevalence of synchronous colorectal cancer, colorectal adenoma, and gastric adenoma than those with MSS gastric cancers (4.8% vs 0.5%, p=0.023; 11.3% vs 3.2%, p=0.011; 3.2% vs 1.2%, p=0.00, respectively). The prevalence of synchronous colorectal adenomas was highest in MSI-L gastric cancers (19.0%), compared with MSI-H (7.3%) or MSS (3.2%) gastric cancers (p=0.002). In addition, there were no significant differences in the prevalence rates of synchronous colorectal adenoma among the MSI-H (13.3%), MSI-L (11.1%), and MSS (12.3%) colorectal cancers (p=0.987). Conclusions: The presence of MSI in gastric cancer may be a predictor of synchronous gastric and colorectal neoplasms, whereas MSI in colorectal cancer is not a predictor of synchronous colorectal adenoma.
참고문헌 (30)
- Boland CR, "A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer", Cancer Res, 58, pp.5248~5257 (1998)
- Shah SN, "Defective mismatch repair, microsatellite mutation bias, and variability in clinical cancer phenotypes", Cancer Res, 70, pp.431~435 (2010)
- Boland CR, "Microsatellite instability in colorectal cancer", Gastroenterology, 138(e3), pp.2073~2087 (2010)
- Liu P, "Microsatellite instability in gastric cancer and pre-cancerous lesions", World J Gastroenterol, 11, pp.4904~4907 (2005)
- Seo HM, "Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype", J Surg Oncol, 99, pp.143~147 (2009)
- Arai T, "Frequent microsatellite instability in papillary and solid-type, poorly differentiated adenocarcinomas of the stomach", Gastric Cancer, 16, pp.505~512 (2013)
- Shin Hyuk Kim, "Microsatellite Instability Is Associated with the Clinicopathologic Features of Gastric Cancer in Sporadic Gastric Cancer Patients", Journal of Gastric Cancer, 10(4), pp.149~154 (2010), 대한위암학회
- Chung HW, "Gastric cancers with microsatellite instability exhibit high fluorodeoxyglucose uptake on positron emission tomography", Gastric Cancer, 16, pp.185~192 (2013)
- Won Hyuk Choe, "High Frequency of Microsatellite Instability in Intestinal-type Gastric Cancer in Korean Patients", The Korean Journal of Internal Medicine, 20(2), pp.116~122 (2005), 대한내과학회
- Markowitz S, "DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers", J Clin Oncol, 18(21), pp.75S~80S (2000)
- Lee SY, "Microsatellite alterations at selected tetranucleotide repeats are associated with morphologies of colorectal neoplasias", Gastroenterology, 139, pp.1519~1525 (2010)
- Yoon YS, "Mismatch repair status in sporadic colorectal cancer: immunohistochemistry and microsatellite instability analyses", J Gastroenterol Hepatol, 26, pp.1733~1739 (2011)
- Cho I, "Risk factors for double primary malignancies and their clinical implications in patients with sporadic gastric cancer", Eur J Surg Oncol, 40, pp.338~344 (2014)
- Ueda E, "Microsatellite instability of cancers and concomitant adenomas in synchronous multiple colorectal cancer patients", J Exp Clin Cancer Res, 21, pp.149~154 (2002)
- Yun HR, "Double primary malignancy in colorectal cancer patients: MSI is the useful marker for predicting double primary tumors", Int J Colorectal Dis, 24, pp.369~375 (2009)
- An JY, "Microsatellite instability in sporadic gastric cancer: its prognostic role and guidance for 5-FU based chemotherapy after R0 resection", Int J Cancer, 131, pp.505~511 (2012)
- Tajima A, "The mismatch repair complex hMutS alpha recognizes 5-fluorouracilmodified DNA: implications for chemosensitivity and resistance", Gastroenterology, 127, pp.1678~1684 (2004)
- Kim HO, "Preoperative colonoscopy for patients with gastric adenocarcinoma", J Gastroenterol Hepatol, 24, pp.1740~1744 (2009)
- Hata K, "Impact of family history of gastric cancer on colorectal neoplasias in young Japanese", Colorectal Dis, 15, pp.42~46 (2013)
- Han HS, "Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness", J Gastroenterol Hepatol, 24, pp.658~666 (2009)
- 정우철, "Genetic Instability in Gastric Epithelial Neoplasias Categorized by the Revised Vienna Classification", Gut and Liver, 4(2), pp.179~185 (2010), 거트앤리버 발행위원회
- Kim JS, "Association between genetic instability and Helicobacter pylori infection in gastric epithelial dysplasia", Gastroenterol Res Pract, 2012, pp.360929~ (2012)
- Lee HS, "Microsatellite instability in synchronous gastric carcinomas", Int J Cancer, 91, pp.619~624 (2001)
- Miyoshi E, "Microsatellite instability is a genetic marker for the development of multiple gastric cancers", Int J Cancer, 95, pp.350~353 (2001)
- Yamashita K, "Microsatellite instability in patients with multiple primary cancers of the gastrointestinal tract", Gut, 46, pp.790~794 (2000)
- Yoon SN, "Clinicopathologic characteristics of colorectal cancer patients with synchronous and metachronous gastric cancer", World J Surg, 34, pp.2168~2176 (2010)
- Abe Y, "Microsatellite instability of each tumor in sporadic synchronous multiple colorectal cancers", Oncol Rep, 8, pp.299~304 (2001)
- Levine AJ, "Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry", Cancer Prev Res, 5, pp.328~335 (2012)
- Arai T, "Role of methylation of the hMLH1 gene promoter in the development of gastric and colorectal carcinoma in the elderly", Geriatr Gerontol Int, 10(1), pp.S207~S212 (2010)
- Leite M, "MSI phenotype and MMR alterations in familial and sporadic gastric cancer", Int J Cancer, 128, pp.1606~1613 (2011)