Changes in Diffusion Metrics of the Red Nucleus in Chronic Stroke Patients With Severe Corticospinal Tract Injury: A Preliminary Study
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Objective To explore plastic changes in the red nucleus (RN) of stroke patients with severe corticospinal tract (CST) injury as a compensatory mechanism for recovery of hand function.Methods The moderate group (MG) comprised 5 patients with synergistic hand grasp movement combined with limited extension, and the severe group (SG) included 5 patients with synergistic hand grasp movement alone. The control group (CG) included 5 healthy subjects. Motor assessment was measured by Motricity Index (MI). Diffusion tensor imaging was analyzed using fractional anisotropy (FA) and radial diffusivity (RD) in the individual regions of interest (ROIs)—bilateral internal capsule and anterior pons for CST injury and bilateral RN for rubrospinal tract (RST) injury. Results The SG showed a significantly lower MI score than the MG mainly due to differences in hand subscores. Significantly reduced FA was observed in both MG and SG compared with CG, while SG showed increased MD and RD in the affected ROIs of CST, and increased FA on the unaffected side compared with CG. However, in the RN ROI, a significantly increased FA and decreased RD on the unaffected side similar to the affected side were found only in the SG. The relative index of FA was lower and RD in SG was higher than in CG in RST.Conclusion The diffusion metrics of RST showed changes in patients with severe CST injury, suggesting that RST may play a role in the recovery of hand function in patients with severe CST injury.
Abstract
Objective To explore plastic changes in the red nucleus (RN) of stroke patients with severe corticospinal tract (CST) injury as a compensatory mechanism for recovery of hand function.Methods The moderate group (MG) comprised 5 patients with synergistic hand grasp movement combined with limited extension, and the severe group (SG) included 5 patients with synergistic hand grasp movement alone. The control group (CG) included 5 healthy subjects. Motor assessment was measured by Motricity Index (MI). Diffusion tensor imaging was analyzed using fractional anisotropy (FA) and radial diffusivity (RD) in the individual regions of interest (ROIs)—bilateral internal capsule and anterior pons for CST injury and bilateral RN for rubrospinal tract (RST) injury. Results The SG showed a significantly lower MI score than the MG mainly due to differences in hand subscores. Significantly reduced FA was observed in both MG and SG compared with CG, while SG showed increased MD and RD in the affected ROIs of CST, and increased FA on the unaffected side compared with CG. However, in the RN ROI, a significantly increased FA and decreased RD on the unaffected side similar to the affected side were found only in the SG. The relative index of FA was lower and RD in SG was higher than in CG in RST.Conclusion The diffusion metrics of RST showed changes in patients with severe CST injury, suggesting that RST may play a role in the recovery of hand function in patients with severe CST injury.
참고문헌 (40)
- Lemon RN. The G. L, "Brown Prize Lecture: Cortical control of the primate hand", Exp Physiol, 78, pp.263~301 (1993)[DOI]
- Nakajima K, "Striking differences in transmission of corticospinal excitation to upper limb motoneurons in two primate species", J Neurophysiol, 84, pp.698~709 (2000)[DOI]
- Ehrsson HH, "Cortical activity in precision-versus power-grip tasks: an fMRI study", J Neurophysiol, 83, pp.528~536 (2000)[DOI]
- Forssberg H, "Neural control of human motor development", Curr Opin Neurobiol, 9, pp.676~682 (1999)[DOI]
- Nowak DA, "Dexterity is impaired at both hands following unilateral subcortical middle cerebral artery stroke", Eur J Neurosci, 25, pp.3173~3184 (2007)[DOI]
- Marshall RS, "Evolution of cortical activation during recovery from corticospinal tract infarction", Stroke, 31, pp.656~661 (2000)[DOI]
- Twitchell TE, "The restoration of motor function following hemiplegia in man", Brain, 74, pp.443~480 (1951)[DOI]
- Ward NS, "Neural correlates of motor recovery after stroke: a longitudinal fMRI study", Brain, 126, pp.2476~2496 (2003)[DOI]
- Ward NS, "Motor system activation after subcortical stroke depends on corticospinal system integrity", Brain, 129, pp.809~819 (2006)[DOI]
- Turton A, "Contralateral and ipsilateral EMG responses to transcranial magnetic stimulation during recovery of arm and hand function after stroke", Electroencephalogr Clin Neurophysiol, 101, pp.316~328 (1996)[DOI]
- Boggio PS, "Hand function improvement with low-frequency repetitive transcranial magnetic stimulation of the unaffected hemisphere in a severe case of stroke", Am J Phys Med Rehabil, 85, pp.927~930 (2006)[DOI]
- Kennedy PR, "Corticospinal, rubrospinal and rubroolivary projections: a unifying hypothesis", Trends Neurosci, 13, pp.474~479 (1990)[DOI]
- ten Donkelaar HJ, "Evolution of the red nucleus and rubrospinal tract", Behav Brain Res, 28, pp.9~20 (1988)[DOI]
- Zaaimi B, "Changes in descending motor pathway connectivity after corticospinal tract lesion in macaque monkey", Brain, 135, pp.2277~2289 (2012)[DOI]
- Whishaw IQ, "Does the red nucleus provide the tonic support against which fractionated movements occur? A study on forepaw movements used in skilled reaching by the rat", Behav Brain Res, 74, pp.79~90 (1996)[DOI]
- Lawrence DG, "The functional organization of the motor system in the monkey. I. The effects of bilateral pyramidal lesions", Brain, 91, pp.1~14 (1968)[DOI]
- Lawrence DG, "The functional organization of the motor system in the monkey. II. The effects of lesions of the descending brain-stem pathways", Brain, 91, pp.15~36 (1968)[DOI]
- Alstermark B, "Motor recovery after serial spinal cord lesions of defined descending pathways in cats", Neurosci Res, 5, pp.68~73 (1987)[DOI]
- Belhaj-Saif A, "Plasticity in the distribution of the red nucleus output to forearm muscles after unilateral lesions of the pyramidal tract", J Neurophysiol, 83, pp.3147~3153 (2000)[DOI]
- Perfiliev S, "Food-taking in the cat investigated with transection of the rubro- and corticospinal tracts", Neurosci Res, 32, pp.181~184 (1998)[DOI]
- Pettersson LG, "Recovery of food-taking in cats after lesions of the corticospinal (complete) and rubrospinal (complete and incomplete) tracts", Neurosci Res, 38, pp.109~112 (2000)[DOI]
- Takenobu Y, "Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke", Neuroimage Clin, 4, pp.201~208 (2013)
- Jang SH, "Change of neural connectivity of the red nucleus in patients with striatocapsular hemorrhage: a diffusion tensor tractography study", Neural Plast, 2015, pp.679815~ (2015)
- Assaf Y, "Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review", J Mol Neurosci, 34, pp.51~61 (2008)[DOI]
- Neil JJ, "Diffusion imaging concepts for clinicians", J Magn Reson Imaging, 27, pp.1~7 (2008)[DOI]
- Yang HS, "The rubrospinal tract in the human brain: diffusion tensor imaging study", Neurosci Lett, 504, pp.45~48 (2011)[DOI]
- van Kuijk AA, "Stimulus-response characteristics of motor evoked potentials and silent periods in proximal and distal upper-extremity muscles", J Electromyogr Kinesiol, 19, pp.574~583 (2009)[DOI]
- Rossini PM, "Non-invasive electrical and magnetic stimulation of the brain, spinal cord and roots: basic principles and procedures for routine clinical application. Report of an IFCN Committee", Electroencephalogr Clin Neurophysiol, 91, pp.79~92 (1994)[DOI]
- Demeurisse G, "Motor evaluation in vascular hemiplegia", Eur Neurol, 19, pp.382~389 (1980)[DOI]
- Berger MA, "Task specificity of finger dexterity tests", Appl Ergon, 40, pp.145~147 (2009)[DOI]
- Dong Y, "The Montreal Cognitive Assessment (MoCA) is superior to the Mini-Mental State Examination (MMSE) for the detection of vascular cognitive impairment after acute stroke", J Neurol Sci, 299, pp.15~18 (2010)[DOI]
- Basser PJ, "Microstructural and physiological features of tissues elucidated by quantitativediffusion-tensor MRI", J Magn Reson B, 111, pp.209~219 (1996)[DOI]
- Sun SW, "Directional correlation characterization and classification of white matter tracts", Magn Reson Med, 49, pp.271~275 (2003)[DOI]
- Stinear CM, "Functional potential in chronic stroke patients depends on corticospinal tract integrity", Brain, 130, pp.170~180 (2007)
- Binkofski F, "Thalamic metabolism and corticospinal tract integrity determine motor recovery in stroke", Ann Neurol, 39, pp.460~470 (1996)[DOI]
- Carey LM, "Motor impairment and recovery in the upper limb after stroke: behavioral and neuroanatomical correlates", Stroke, 36, pp.625~629 (2005)[DOI]
- Butefisch CM, "Recruitment of contralesional motor cortex in stroke patients with recovery of hand function", Neurology, 64, pp.1067~1069 (2005)[DOI]
- Fillard P, "Quantitative evaluation of 10 tractography algorithms on a realistic diffusion MR phantom", Neuroimage, 56, pp.220~234 (2011)[DOI]
- Hicks TP, "The mammalian red nucleus and its role in motor systems, including the emergence of bipedalism and language", Prog Neurobiol, 96, pp.165~175 (2012)[DOI]
- Yamaguchi K, "Development of the human magnocellular red nucleus: a morphological study", Brain Dev, 28, pp.431~435 (2006)[DOI]
