ABO 혈액형 부적합 신장이식 환자에서혈연 간 신장이식과 비혈연 간 신장이식의 성적 비교
Clinical Outcomes between Living Related and Living Unrelated Kidney Transplantation in ABO-Incompatible Kidney Transplant Recipients
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초록
Background/Aims: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previousstudies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR)KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. Inthis study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients. Methods: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors,Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications. Results: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different betweenthe two groups. Conclusions: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.
Abstract
Background/Aims: Kidney transplantation (KT) is the best treatment for end-stage renal disease patients. Although previousstudies have demonstrated that the clinical outcome following living related (LR) KT is better than that following unrelated (LUR)KT in ABO-compatible KT recipients, recent studies showed no differences in clinical outcomes between the two treatments. Inthis study, we compared the clinical outcomes of LR and LUR KT in ABO-incompatible KT recipients. Methods: From January 2011 to August 2013, 19 cases of ABO-incompatible KT were analyzed retrospectively. Eight kidneys (7cases of parent-offspring and 1 case of siblings, Group 1) were donated from living-related donors and 11 (all spousal donors,Group 2) from living-unrelated donors. We investigated patient survival, graft survival, acute rejection, graft function, and complications. Results: On Kaplan-Meier analysis, patient and graft survival during follow-up were 87.5% and 87.5% in Group 1; both were100% in Group 2. Acute rejection, graft function, and medical and surgical complications were not significantly different betweenthe two groups. Conclusions: The short-term clinical outcomes between LR and LUR KT in ABO-incompatible KT recipients were equivalent. Most domestic cases of LUR KT are from spousal donors and the spousal donor will be a major donor in ABO-incompatible KT patients.
참고문헌 (15)
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