고도근시에서 시신경유두주위 위축 범위에 따른빛간섭단층촬영의 녹내장 진단력 비교
Comparison of Diagnostic Power Among OCT Parameters According to Peripapillary Atrophy in High Myopic Glaucoma
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목적: 고도근시안에서 시신경유두주위 위축 범위에 따른 여러 빛간섭단층촬영 검사들의 녹내장 진단력을 비교하고자 한다. 대상과 방법: 시신경유두주위 위축과 -6 디옵터 이상의 고도근시를 동반한 녹내장 환자 31명 50안을 대상으로 시신경유두주위 위축영역이 빛간섭단층촬영기의 시신경유두 분석 원을 넘어서 분포하는 A군과 원 안쪽에 국한된 B군으로 나누어 유두주위 망막신경섬유층,황반부 망막전층, 황반부 신경절세포-내망상층 두께를 측정하여 진단력을 비교하기 위하여 area under receiver characteristics curve (AUC)를 분석하였다. 결과: 두 군 사이에 연령, 성비, 안압, 시신경유두 크기, 자동시야검사의 mean deviation은 유의한 차이가 없었으며 A군에서 근시의정도가 유의하게 컸다(평균 -11.9 vs -7.3 디옵터, p=0.002). 각 검사의 평균치의 비교에서 A군에서는 신경절세포-내망상층의 AUC가0.865로 유두주위 망막신경섬유층의 0.742와 황반부 망막의 0.728보다 유의하게 높았으며(p<0.05), 가장 높은 진단력을 가지는 구역간의 비교에서도 신경절세포-내망상층의 AUC가 0.865로 유두주위 망막신경섬유층의 0.773보다 유의하게 높았다(p=0.046). A, B군간 굴절력을 대응시킨 부분군 분석에서도 Sub-A군에서는 가장 높은 진단력을 가지는 구역이 신경절세포-내망상층의 AUC가 0.968로유두주위 망막신경섬유층의 0.755와 황반부 망막의 0.827보다 유의하게 높았다(p<0.05). B군과 Sub-B군에서는 각 검사 간에 유의한차이가 없었다(p>0.05). 결론: 시신경유두주위 위축이 빛간섭단층촬영의 분석 원을 넘어서 분포하는 고도근시에서는 신경절세포-내망상층 검사가 녹내장 진단에 효과적일 것으로 보인다.
Abstract
Purpose: To evaluate diagnostic power to detect glaucoma in high myopic eyes with peripapillary atrophy among optical coherence tomography (OCT) parameters. Methods: Fifty eyes of 31 glaucoma patients with myopia of -6.00 diopters or less and a peripapillary atrophy (PPA) were classified into a group with a PPA located beyond the circumpapillary OCT scan circle (group A) and a group with a PPA confined within the scan circle (group B). Circumpapillary retinal nerve fiber layer (cpRNFL), total macula (TM), and ganglion cell-inner plexiform layer (GCIPL) thickness were measured in each group and the diagnostic power of each measurement was compared by area under the receiver operating characteristic curve (AUC). Results: There were no significant differences in the age, gender, intraocular pressure, optic disc size, and mean deviation between the 2 groups. The spherical equivalent of group A was significantly larger than group B (mean -11.9 vs. -7.3 diopters,p = 0.002). In group A, the AUC of average GCIPL thickness was significantly higher than average cpRNFL and average TM thickness (p < 0.05). Additionally, when comparing parameters that showed the highest AUC value in each method,the AUC of GCIPL thickness was significantly higher than cpRNFL thickness (p = 0.046). In subgroup analysis of spherical equivalent matching between the 2 groups (subgroup A and B), the highest AUC value of GCIPL thickness was significantly higher than cpRNFL and TM thickness in subgroup A (p < 0.05). In group B and subgroup B, there was no statistical significance among AUC values of the 3 different methods (p > 0.05). Conclusions: Assessment of GCIPL parameters is a useful technique for glaucoma diagnosis in patients with high myopia and PPA extending beyond circumpapillary OCT scan circle.
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