Health Outcomes Associated with Hypolipidemia: a Scoping Review
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Objective: This review summarizes current evidence on the possible effects of hypolipidemia, a state of low concentration of blood lipids, on health outcomes. Methods: A review was conducted of articles published across 5 electronic databases (PubMed, EMBASE, Cochrane Central Resister of Controlled Trials, RISS, and ScienceON). Prospective and retrospective clinical studies were included. Results: In total, 84 studies were assessed. Depending on the subtypes of hypolipidemia, hypocholesterolemia and hypobetalipoproteinemia were associated with severity of liver disease and sepsis, mortality of COVID-19, and prevalence of cancer and mental illness. Hypoalphalipoproteinemia showed similar findings but was also associated with cardiovascular and cerebrovascular disease. Conclusions: Hypolipidemia may mediate lipid metabolism in the liver, immune activation, metabolic function, and recovery, contributing to disease severity and mortality. This highlights the need to monitor and assess hypolipidemia in patients with specific health conditions, as well as incorporate treatment plans accordingly.
Abstract
Objective: This review summarizes current evidence on the possible effects of hypolipidemia, a state of low concentration of blood lipids, on health outcomes. Methods: A review was conducted of articles published across 5 electronic databases (PubMed, EMBASE, Cochrane Central Resister of Controlled Trials, RISS, and ScienceON). Prospective and retrospective clinical studies were included. Results: In total, 84 studies were assessed. Depending on the subtypes of hypolipidemia, hypocholesterolemia and hypobetalipoproteinemia were associated with severity of liver disease and sepsis, mortality of COVID-19, and prevalence of cancer and mental illness. Hypoalphalipoproteinemia showed similar findings but was also associated with cardiovascular and cerebrovascular disease. Conclusions: Hypolipidemia may mediate lipid metabolism in the liver, immune activation, metabolic function, and recovery, contributing to disease severity and mortality. This highlights the need to monitor and assess hypolipidemia in patients with specific health conditions, as well as incorporate treatment plans accordingly.