The effect of ginger and metoclopramide in the prevention of nausea and vomiting during and after surgery in cesarean section under spinal anesthesia
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ObjectivePostoperative nausea and vomiting is one of the most common side effects after anesthesia in surgeries, such ascesarean section. This study aimed to investigate the effect of ginger and metoclopramide in the prevention ofnausea and vomiting during and after cesarean section. MethodsThis clinical trial was conducted on 180 patients aged 18–40 years who underwent cesarean section under spinalanesthesia. The first group received 10 mg of metoclopramide via intravenous injection (metoclopramide group), andthe second group received 1 g of oral ginger (ginger group) half an hour before spinal anesthesia. The frequency andseverity of nausea and vomiting during surgery and at 2, 6, 12, and 24 hours postoperatively were compared in bothgroups. To analyze the results, the t-test, chi-square test, and Mann-Whitney test were used. ResultsThere was no significant difference in the frequency of nausea and vomiting between the 2 groups during operation,2 hours and 6 hours after surgery (P=0.182, 0.444 and 0.563 respectively). The severity of nausea and vomiting wasalso similar in the 2 groups (P=0.487 and 0.652 respectively); however, the metoclopramide group had a lower systolicblood pressure (P<0.001; df=2.176; f=18.66) and mean arterial pressure (P<0.001; df=2.176; f=6.36) than the gingergroup. ConclusionThe results revealed that ginger reduced nausea and vomiting to the same extent as metoclopramide in patientsundergoing cesarean section. Trial RegistrationIranian Center for Clinical Trials Identifier: IRCT201611028611N3
Abstract
ObjectivePostoperative nausea and vomiting is one of the most common side effects after anesthesia in surgeries, such ascesarean section. This study aimed to investigate the effect of ginger and metoclopramide in the prevention ofnausea and vomiting during and after cesarean section. MethodsThis clinical trial was conducted on 180 patients aged 18–40 years who underwent cesarean section under spinalanesthesia. The first group received 10 mg of metoclopramide via intravenous injection (metoclopramide group), andthe second group received 1 g of oral ginger (ginger group) half an hour before spinal anesthesia. The frequency andseverity of nausea and vomiting during surgery and at 2, 6, 12, and 24 hours postoperatively were compared in bothgroups. To analyze the results, the t-test, chi-square test, and Mann-Whitney test were used. ResultsThere was no significant difference in the frequency of nausea and vomiting between the 2 groups during operation,2 hours and 6 hours after surgery (P=0.182, 0.444 and 0.563 respectively). The severity of nausea and vomiting wasalso similar in the 2 groups (P=0.487 and 0.652 respectively); however, the metoclopramide group had a lower systolicblood pressure (P<0.001; df=2.176; f=18.66) and mean arterial pressure (P<0.001; df=2.176; f=6.36) than the gingergroup. ConclusionThe results revealed that ginger reduced nausea and vomiting to the same extent as metoclopramide in patientsundergoing cesarean section. Trial RegistrationIranian Center for Clinical Trials Identifier: IRCT201611028611N3
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