본문 바로가기
KERD
논문KCI 등재

Assessment of the risk factors associated with multidrug-resistant tuberculosis in Sudan: a case-control study

Hamdan Mustafa Hamdan Ali|Adel Hussein Elduma|Mohammad Ali Mansournia|Abbas Rahimi Foroushani|Asrar M A/Salam Elegail|Asma Elsony|Kourosh Holakouie-Naieni
한국역학회 (Korean Society of Epidemiology)|2019.01|Epidemiology and Health|제41권 |pp. 1-9

0

조회

0

다운로드

0

인용

0

참고문헌

키워드

Risk factorsTuberculosisSudanMultidrug resistant

초록

OBJECTIVES: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS: This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS: A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS: Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients’ adherence to treatment, and to reduce contact with MDR-TB patients.

Abstract

OBJECTIVES: The emergence of multidrug-resistant tuberculosis (MDR-TB) is a major challenge for the global control of tuberculosis (TB). The aim of this study was to determine the risk factors associated with MDR-TB in Sudan. METHODS: This case-control study was conducted from May 2017 to February 2019. Patients newly diagnosed with MDR-TB were selected as cases, and controls were selected from TB patients who responded to first-line anti-TB drugs. A questionnaire was designed and used to collect data from study participants. Logistic regression was used to evaluate associations between risk factors and MDR-TB infection. The best multivariate model was selected based on the likelihood ratio test. RESULTS: A total of 430 cases and 860 controls were selected for this study. A history of previous TB treatment (adjusted odds ratio [aOR], 54.85; 95% confidence interval [CI], 30.48 to 98.69) was strongly associated with MDR-TB infection. We identified interruption of TB treatment (aOR, 7.62; 95% CI, 3.16 to 18.34), contact with MDR-TB patients (aOR, 5.40; 95% CI, 2.69 to 10.74), lower body weight (aOR, 0.89; 95% CI, 0.87 to 0.91), and water pipe smoking (aOR, 3.23; 95% CI, 1.73 to 6.04) as factors associated with MDR-TB infection. CONCLUSIONS: Previous TB treatment and interruption of TB treatment were found to be the main predictors of MDR-TB. Additionally, this study found that contact with MDR-TB patients and water pipe smoking were associated with MDR-TB infection in Sudan. More efforts are required to decrease the rate of treatment interruption, to strengthen patients’ adherence to treatment, and to reduce contact with MDR-TB patients.

참고문헌 (41)

  1. "Global tuberculosis report 2018"[URL]
  2. Musa BM, "Trends in prevalence of multi drug resistant tuberculosis in sub-Saharan Africa: a systematic review and meta-analysis", PLoS One, 12, pp.e0185105~ (2017)
  3. "Global tuberculosis report 2017"[URL]
  4. Faustini A, "Risk factors for multidrug resistant tuberculosis in Europe : a systematic review", Thorax, 61, pp.158~163 (2006)
  5. Goble M, "Treatment of 171 patients with pulmonary tuberculosis resistant to isoniazid and rifampin", N Engl J Med, 328, pp.527~532 (1993)
  6. "Companion handbook to the WHO guidelines for the programmatic management of drug-resistant tuberculosis" (2014)[URL]
  7. Günther G, "Multidrug-resistant tuberculosis in Europe, 2010-2011", Emerg Infect Dis, 21, pp.409~416 (2015)
  8. Deressa MA, "Risk factors of multi-drug resistant tuberculosis in Addis Ababa, Ethiopia : a matched case–control study", Open Access Libr J, 1, pp.1~8 (2014)
  9. Casal M, "A case-control study for multidrug-resistant tuberculosis : risk factors in four European countries", Microb Drug Resist, 11, pp.62~67 (2005)
  10. Hirpa S, "Determinants of multidrug-resistant tuberculosis in patients who underwent first-line treatment in Addis Ababa : a case control study", BMC Public Health, 13, pp.782~ (2013)
  11. Zhang C, "Determinants of multidrug-resistant tuberculosis in Henan province in China : a case control study", BMC Public Health, 16, pp.42~ (2016)
  12. "Tuberculosis country profiles (Sudan)"[URL]
  13. Khalid FA, "Tuberculosis drug resistance isolates from pulmonary tuberculosis patients, Kassala State, Sudan", Int J Mycobacteriol, 4, pp.44~47 (2015)
  14. Eldirdery MM, "Rapid detection of multi drug resistant-tuberculosis using Line Probe Assay(LPA)in Sudan", Eur Acad Res, 3, pp.10755~10768 (2016)
  15. Adam MA, "First-line drug resistance patterns of Mycobacterium tuberculosis complex isolates from re-treatment patients from Sudan", J Tuberc Res, 4, pp.98~104 (2016)
  16. "Sudan: multiple indicator cluster survey 2014" (2016)[URL]
  17. Lema NA, "Risk factors associated with multidrug resistant tuberculosis among patients referred to Kibong’oto Infectious Disease Hospital in northern Tanzania", Tanzan J Health Res (2016)[DOI]
  18. Andrews JR, "Predictors of multidrug- and extensively drug-resistant tuberculosis in a high HIV prevalence community", PLoS One, 5, pp.e15735~ (2010)
  19. Mollel EW, "Predictors for mortality among multidrug-resistant tuberculosis patients in Tanzania", J Trop Med, 2017, pp.9241238~ (2017)
  20. Rifat M, "Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors", PLoS One, 9, pp.e105214~ (2014)
  21. Desissa F, "Risk factors for the occurrence of multidrug-resistant tuberculosis among patients undergoing multidrug-resistant tuberculosis treatment in East Shoa, Ethiopia", BMC Public Health, 18, pp.422~ (2018)
  22. Workicho A, "Risk factors for multidrug-resistant tuberculosis among tuberculosis patients : a case-control study", Infect Drug Resist, 10, pp.91~96 (2017)
  23. Ali MO, "Determination of the prevalence of tuberculosis with drug-resistant strains of Mycobacterium tuberculosis in Khartoum, Gazira and camps for displaced people, Sudan", pp.2002
  24. Stosic M, "Risk factors for multidrug-resistant tuberculosis among tuberculosis patients in Serbia : a case-control study", BMC Public Health, 18, pp.1114~ (2018)
  25. Rifat M, "Factors related to previous tuberculosis treatment of patients with multidrug-resistant tuberculosis in Bangladesh", BMJ Open, 5, pp.e008273~ (2015)
  26. Chen S, "Risk factors for multidrug resistance among previously treated patients with tuberculosis in eastern China: a case-control study", Int J Infect Dis, 17, pp.e1116~e1120 (2013)
  27. Hirpa S, "Determinants of multidrug-resistant tuberculosis in patients who underwent first-line treatment in Addis Ababa : a case control study", BMC Public Health, 13, pp.782~ (2013)
  28. Mulu W, "Risk factors for multidrug resistant tuberculosis patients in Amhara National Regional State", Afr Health Sci, 15, pp.368~377 (2015)
  29. Rifat M, "Development of multidrug resistant tuberculosis in Bangladesh: a case-control study on risk factors", PLoS One, 9, pp.e105214~ (2014)
  30. Lomtadze N, "Prevalence and risk factors for multidrug-resistant tuberculosis in the Republic of Georgia : a population-based study", Int J Tuberc Lung Dis, 13, pp.68~73 (2009)
  31. Fregona G, "Risk factors associated with multidrug-resistant tuberculosis in Espírito Santo, Brazil", Rev Saude Publica, 51, pp.41~ (2017)
  32. Henostroza G, "The high burden of tuberculosis (TB) and human immunodeficiency virus (HIV) in a large Zambian prison: a public health alert", PLoS One, 8, pp.e67338~ (2013)
  33. O’Grady J, "Tuberculosis in prisons in sub-Saharan Africa--the need for improved health services, surveillance and control", Tuberculosis(Edinb), 91, pp.173~178 (2011)
  34. Stephens TT, "History of prior TB infection and HIV", AIDS risk behaviours among a sample of male inmates in the USA, 2003, pp.14, 514~518
  35. Wang MG, "Association between tobacco smoking and drug-resistant tuberculosis", Infect Drug Resist, 11, pp.873~887 (2018)
  36. Squire SB, "Catastrophic care-seeking costs as an indicator for lung health", BMC Proc, 9(Suppl 10), pp.S4~ (2015)
  37. Hassanain SA, "Conflict and tuberculosis in Sudan : a 10-year review of the National Tuberculosis Programme, 2004-2014", Confl Health, 12, pp.18~ (2018)
  38. "Prevalence of HIV, total (% of population ages 15-49)"[URL]
  39. Weyer K, "Determinants of multidrug-resistant tuberculosis in South Africa : results from a national survey", S Afr Med J, 97, pp.1120~1128 (2007)
  40. Khan MS, "Preventing emergence of drug resistant tuberculosis in Myanmar’s transitioning health system", Health Policy Plan, 32(suppl_2), pp.ii43~ii50 (2017)
  41. Sun Y, "Comparison of characteristics and mortality in multidrug resistant(MDR)and non-MDR tuberculosis patients in China", BMC Public Health, 15, pp.1027~ (2015)

관련 논문AI추천

Phenotypic and Genotypic Analysis of Anti-Tuberculosis Drug Resistance in Mycobacterium tuberculosis Isolates in Myanmar김경준, 김창기, 송선대, 이종석, 장철훈, 조상래, Mi Mi Htwe, Phyu Win Ei, Thandar Lwin, Thyn Lei Swe, Wah Wah Aung, Wint Wint Nyunt대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제5호Timing and predictors of death during treatment in patients with multidrug/rifampin-resistant tuberculosis in South Korea강영애, 최홍조, Dawoon Jeong, Doosoo Jeon, M.D., Ph.D., Eunjeong Son, Jeongha Mok대한내과학회 · The Korean Journal of Internal Medicine2024 · 제39권 제4호Trend of multidrug and fluoroquinolone resistance in Mycobacterium tuberculosis isolates from 2010 to 2014 in Korea: a multicenter study강보형, 김현석, 목정하, 이태훈, 이현경, 장항제, 전두수, 조유지대한내과학회 · The Korean Journal of Internal Medicine2019 · 제34권 제2호Diagnosis and treatment of multidrug-resistant tuberculosis장종걸, 정진홍영남대학교 의과대학 · Journal of Yeungnam Medical Science2020 · 제37권 제4호Association between Body Mass Index and Sputum Culture Conversion among South Korean Patients with Multidrug Resistant Tuberculosis in a Tuberculosis Referral Hospital김성환, 김종덕, 김종우, 문성호, 박현오, 변정훈, 양준호, 이정은, 장인석대한감염학회 · Infection and Chemotherapy2016 · 제48권 제4호Comparison of Patients Who Were Not Evaluated and Lost to Follow-Up with Multidrug/Rifampin-Resistant Tuberculosis in South Korea강영애, 강희연, 김희선, 김희진, 목정하, 전두수, 정다운, 최홍조연세대학교의과대학 · Yonsei Medical Journal2025 · 제66권 제1호

이 간행물의 다른 논문 (50건)

Physical activity level in Korean adults: the Korea National Health and Nutrition Examination Survey 2017Ki-Yong Anpp. 1-10A large outbreak of Salmonella enterica serovar Thompson infections associated with chocolate cake in Busan, Korea김은희, 박은희, 정혜선, Sunhee Park, 황인영, 손현진, Seungjin Kim, Wonseo Park, Byoungseon Ahn, Dongkeun Kim, 은영덕pp. 1-8Epidemiological characteristics of HIV infected Korean: Korea HIV/AIDS Cohort Study최희정, 최보율, Dae Won Park, Soo Min Kim, Youn Jeong Kim, June Kim, Jun Young Choi, Sang-Il Kim, 최윤수, Shin Woo Kim, Joon Young Song, Hyo Youl Kim, Mee-Kyung Kee, YoungHyun Shin, Myeongsu Yoopp. 1-9Causes and countermeasures for repeated outbreaks of hepatitis A among adults in Korea손현진, 최보율, 기모란pp. 1-7Bilirubin and risk of ischemic heart disease in Korea: a two-sample Mendelian randomization study지선하, 이선주, 이지영, 김희진, Christina Jeon, Keum Ji Jungpp. 1-5
원문 보기