The Effect of Silk Membrane Plus 3% 4-hexylresorcinol on Guided Bone Regeneration in a Rabbit Calvarial Defect Model
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The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (μ-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by μ-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.
Abstract
The objective of this study was to evaluate the bone regeneration capability of silk membrane plus 3% 4-hexylresorcinol (3% 4-HR plus SM) in a rabbit calvarial defect model. Twenty New Zealand white rabbits were used in this study. Bilateral round shaped defects were created in the parietal bone (diameter: 8.0 mm). And the defects were covered with (1) 3% 4-HR plus SM, (2) collagen membrane (CM), (3) no graft material. After surgery, the animals were sacrificed at 4 weeks and 8 weeks. Bone regeneration was analyzed in each section by micro-computerized tomography (μ-CT). And Hematoxylin and eosin stains were used for histological analysis. As measured by μ-CT analysis 4 weeks after surgery, the average of new bone formation in animals treated with 3% 4-HR plus SM was greater than that of animals treated with CM. and the difference was statistically significant. And well organized lamella bones were observed in the histological view of the 3% 4-HR plus SM group. Therefore, more bone regeneration was seen in animals treated with 3% 4-HR plus SM than in those treated with CM or uncovered control.
참고문헌 (35)
- Altman GH, "Silk-based biomaterials", Biomaterials, 24, pp.401~416 (2003)
- Arai T, "Biodegradation of Bombyx mori silk fibroin fibers and films", J Appl Polm Sci, 91, pp.2383~2390 (2003)
- Aramwit P, "Monitoring of inflammatory mediators induced by silk sericin", J Biosci Bioeng, 107, pp.556~561 (2009)
- Buser D, "Localized ridge augmentation with autografts and barrier membranes", Periodontol 2000, 19, pp.151~163 (2007)
- Cao Y, "Biodegradation of silk biomaterials", Int J Mol Sci, 10, pp.1514~1524 (2009)
- Dal Pra I, "De novo engineering of reticular connective tissue in vivo by silk fibroin nonwoven materials", Biomaterials, 26, pp.1987~1999 (2005)
- Gosline JM, "The structure and properties of spider silk", Endeavour, 10, pp.37~43 (1986)
- Gotfredsen K, "Evaluation of guided bone generation around implants placed into fresh extraction sockets: an experimental study in dogs", J Oral Maxillofac Surg, 51, pp.879~884 (1993)
- Gottlow J, "Guided tissue regeneration using bioresorbable and non-resorbable devices: initial healing and long-term results", J Periodontol, 64, pp.1157~1165 (1993)
- Iglhaut J, "Progenitor cell kinetics during guided tissue regeneration in experimental periodontal wounds", J Periodontal Res, 23, pp.107~117 (1988)
- Imbronito AV, "Healing of alveolar bone in resorbable and non-resorbable membraneprotected defects. A histologic pilot study in dogs", Biomaterials, 23, pp.4079~4086 (2002)
- Iyidogan N, "Effect of L-cysteine, kojic acid and 4-hexylresorcinol combination on inhibition of enzymatic browning in Amasya apple juice", Journal of Food Engineering, 62, pp.299~304 (2004)
- Kim J, "Comparison of methods for the repair of acute tympanic membrane perforations: silk patch vs. paper patch", Wound Rep Reg, 18, pp.132~138 (2010)
- 김민근, "가토의 두정골 결손부 모델에서 수산화인회석에 4-hexylresorcinol을 혼합하여 만든 인공합성골이식재의 골형성효과에 대한 연구", Maxillofacial Plastic Reconstructive Surgery, 34(6), pp.377~383 (2012), 대한악안면성형재건외과학회
- Kim S-G, "Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants", J Oral Maxillofac Surg, 69, pp.e354~e363 (2011)
- Kim S-G, "4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells", Oncol Rep, 26, pp.1527~1532 (2011)
- Kim UJ, "Structure and properties of silk hydrogels", Biomacromolecules, 5, pp.786~792 (2004)
- Kodama T, "The effect of various concentrations of collagen barrier on periodontal wound healing", J Periodontol, 60, pp.205~210 (1989)
- Kozubek A, "Resorcinolic lipids, the natural nonisoprenoid phenolic amphiphiles and their biological activity", Chem Rev, 99, pp.1~26 (1999)
- López-Caballero M, "Spraying of 4-hexylresorcinol based formulations to prevent enzymatic browning in Norway lobsters(Nephrops norvegicus)during chilled storage", Food chemistry, 100, pp.147~155 (2007)
- 이상운, "가토 두개골 결손부 모델에서 테트라사이클린 함유 실크 파이브로인 차폐막의 골유도 재생 효과", Maxillofacial Plastic Reconstructive Surgery, 34(5), pp.293~298 (2012), 대한악안면성형재건외과학회
- Ling LJ, "The influence of membrane exposure on the outcomes of guided tissue regeneration: clinical and microbiological aspects", J Periodontal Res, 38, pp.57~63 (2003)
- Minabe M, "Different cross-linked types of collagen implanted in rat palatal gingiva", J Periodontol, 60, pp.35~43 (1989)
- Minoura N, "Physico-chemical properties of silk fibroin membrane as a biomaterial", Biomaterials, 11, pp.430~434 (1990)
- Rabbani G, "The treatment of Fasciolopsis buski infection in children: a comparison of thiabendazole, mebendazole, levamisole, pyrantel pamoate, hexylresorcinol and tetrachloroethylene", Trans R Soc Trop Med Hyg, 79, pp.513~515 (1985)
- Rakhmatia YD, "Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications", J Prosthodont Res, 57, pp.3~14 (2013)
- Retzepi M, "Guided bone regeneration: biological principle and therapeutic applications", Clin Oral Impl Res, 21, pp.567~576 (2010)
- Rothamel D, "Biodegradation of differently cross-linked collagen membranes: an experimental study in the rat", Clin Oral Impl Res, 16, pp.369~378 (2005)
- Sánchez AR, "Tetracycline and other tetracycline- derivative staining of the teeth and oral cavity", Int J Dermatol, 43, pp.709~715 (2004)
- Sanctis MD, "Bacterial colonization of bioabsorbable barrier material and periodontal regeneration", J Periodontol, 67, pp.1193~1200 (1996)
- Schenk R, "Healing pattern of bone regeneration in membrane-protected defects: a histologic study in the canine mandible", Int J Oral Maxillofac Implants, 9, pp.13~ (1994)
- Sofia S, "Functionalized silk-based biomaterials for bone formation", J Biomed Master Res, 54, pp.139~148 (2000)
- Song JY, "Accelerated healing with the use of a silk fibroin membrane for the guided bone regeneration technique", Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 112, pp.e26~e33 (2011)
- Um IC, "Structural characteristics and properties of the regenerated silk fibroin prepared from formic acid", Int J Biol Macromol, 29, pp.91~97 (2001)
- Young C, "Laboratory : the use of hexylresorcinol in the treatment of typhoid carriers", Am J Public Health(N Y), 17, pp.279~280 (1927)
