Ebola Hemorrhagic Fever Outbreaks: Diagnosis for Effective Epidemic Disease Management and Control
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The first Ebola hemorrhagic fever outbreak occurred in the Democratic Republic of Congo and Sudan in 1976 and then emerged in West Africa in 2014 with a total of 27,741 cases and 11,284 deaths. The fever is caused by the Ebola virus, which belongs to the Filoviridae family and contains a ssRNA genome. The known subtypes of the virus are Bundibugyo ebolavirus, Reston ebolavirus, Sudan ebolavirus, Taï Forest ebolavirus, and Zaire ebolavirus. The Ebola outbreak was historically originated majorly from the East and Central African tropical belt. The current outbreaks in West Africa caused numerous deaths and spread fear in global society. In the absence of effective treatment strategies and any vaccine, accurate diagnosis is the most important contributing factor in the management and control of the epidemic disease. WHO (World Health Organization) has announced emergency guidance for the selection and use of Ebola in in vitro diagnostic assays. Numerous companies and research institutions have studied the various diagnosis methods and identified four WHO procurement approved as diagnosis kits: RealStar Ebolavirus Screen RTPCR kit 1.0 (Altona), Liferiver-Ebola Virus (EBOV) Real time RT-PCR kit, Xpert Ebola Assay, and ReEBOV Antigen Rapid Test Kit. The efficiency of novel diagnostic kits such as Rapid Diagnosis Test (RDT) is currently being evaluated
Abstract
The first Ebola hemorrhagic fever outbreak occurred in the Democratic Republic of Congo and Sudan in 1976 and then emerged in West Africa in 2014 with a total of 27,741 cases and 11,284 deaths. The fever is caused by the Ebola virus, which belongs to the Filoviridae family and contains a ssRNA genome. The known subtypes of the virus are Bundibugyo ebolavirus, Reston ebolavirus, Sudan ebolavirus, Taï Forest ebolavirus, and Zaire ebolavirus. The Ebola outbreak was historically originated majorly from the East and Central African tropical belt. The current outbreaks in West Africa caused numerous deaths and spread fear in global society. In the absence of effective treatment strategies and any vaccine, accurate diagnosis is the most important contributing factor in the management and control of the epidemic disease. WHO (World Health Organization) has announced emergency guidance for the selection and use of Ebola in in vitro diagnostic assays. Numerous companies and research institutions have studied the various diagnosis methods and identified four WHO procurement approved as diagnosis kits: RealStar Ebolavirus Screen RTPCR kit 1.0 (Altona), Liferiver-Ebola Virus (EBOV) Real time RT-PCR kit, Xpert Ebola Assay, and ReEBOV Antigen Rapid Test Kit. The efficiency of novel diagnostic kits such as Rapid Diagnosis Test (RDT) is currently being evaluated
참고문헌 (22)
- "Centers for Disease Control and Prevention's Public Health Image Library (PHIL)"[URL]
- Rougeron V, "Ebola and Marburg haemorrhagic fever", J. Clin. Virol, 64, pp.111~119 (2015)
- Falasca L, "Molecular mechanisms of Ebola virus pathogenesis: focus on cell death", Cell Death Differ, 22, pp.1250~1259 (2015)
- "What you need to know about Ebola. TORONTO SUN 2014 WEDNESDAY" (2014)[URL]
- Leroy EM, "Ebola and Marburg haemorrhagic fever viruses: major scientific advances, but a relatively minor public health threat for Africa", Clin. Microbiol. Infect, 17, pp.964~976 (2011)
- Feldmann H, "Ebola haemorrhagic fever", Lancet, 377, pp.849~862 (2011)
- Team WIS, "Ebola haemorrhagic fever in Sudan, 1976", Bullein of the World Health Organization, 56, pp.247~270 (1978)
- Bwaka MA, "Ebola hemorrhagic fever in Kikwit, Democratic Republic of the Congo: clinical observations in 103 patients", J. Infect. Dis, 179, pp.S1~S7 (1999)
- Lamunu M, "Containing a haemorrhagic fever epidemic:the Ebola experience in Uganda (October 2000-January 2001)", Int. J. Infect. Dis, 8, pp.27~37 (2004)
- "Situation Summary Data Published on 12 November 2014. Ebola data and statistics 2014"[URL]
- "Situation Summary Data Published on 02 January 2015. Ebola data and statistics 2015"[URL]
- "Situation Summary Data Published on 01 April 2015. Ebola data and statistics 2015"[URL]
- "Situation Summary Data Published on 05 August 2015. Ebola data and statistics 2015"[URL]
- "Diagnostics. Essential medicines and health products" (2014)[URL]
- "Selection and Use of Ebola in vitro Diagnostic Assays. Emergencies preparedness, response 2015"[URL]
- Perkins MD, "What Ebola tells us about outbreak diagnostic readiness", Nat. Biotechnol, 33, pp.464~469 (2015)
- "RealStar® Filovirus Screen RT-PCR Kit 1.0, in WHO Emergency Quality Assessment Mechanism for EVD IVDs", ~
- "RealStar® Ebolavirus RT-PCR Kit*"[URL]
- "Xpert® Ebola Assay, in WHO Emergency Use Assessment and Listing for EVD IVDs", ~
- "ReEBOV™ Antigen Rapid Test Kit, in WHO Emergency Use Assessment and Listing for Ebola Virus Disease IVDs", ~
- Broadhurst MJ, "ReEBOV Antigen Rapid Test kit for point-of-care and laboratory-based testing for Ebola virus disease: a field validation study", Lancet, 386, pp.867~874 (2015)
- Strecker T, "Field evaluation of capillary blood samples as a collection specimen for the rapid diagnosis of ebola virus infection during an outbreak emergency", Clin. Infect. Dis, 61, pp.669~675 (2015)