Pharmacological Basis for the Neurocognitive Effect of Atypical Antipsychotic Drugs
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Cognitive impairment is a key feature of schizophrenia and may be the most important determinant of outcome in schizophrenia. Certain kinds of atypical antipsychotic drugs (APDs) have been reported to improve cognitive symptoms of schizophrenia, although little is known about the mechanism of this action. The aim of this paper is to consider the pharmacological basis for the superior efficacy of atypical APDs on cognitive function. In animal studies, atypical APDs have demonstrated to modulate dopamine (DA) and acetylcholine (Ach) neurotransmission preferentially in the cortical areas. Atypical APDs, unlike typical APDs,increase DA release in the prefrontal cortex to a greater extent than in the subcortical regions such as the striatum and nucleus accumbens, as measured by in vivo microdialysis. This preferential effect of atypical APDs may be related to their common receptor binding profiles such as greater affinities to serotonin (5-HT)2A receptors than DA-D2 receptors, in addition with significant ability to stimulate 5-HT1A receptors. Atypical APDs, but not typical APDs, also induce Ach release in the prefrontal cortex and hippocampus. Despite antagonism by some atypical APDs to muscarinic Ach receptors, these drugs may counteract it with an increase in Ach release. Thus, the greater ability of atypical APDs than typical APDs to enhance the release of DA and Ach in the cortical regions may be related to the neurocognitive effect of atypical APDs that are thought to ameliorate the hypofrontality responsible for cognitive deficits of schizophrenia.
Abstract
Cognitive impairment is a key feature of schizophrenia and may be the most important determinant of outcome in schizophrenia. Certain kinds of atypical antipsychotic drugs (APDs) have been reported to improve cognitive symptoms of schizophrenia, although little is known about the mechanism of this action. The aim of this paper is to consider the pharmacological basis for the superior efficacy of atypical APDs on cognitive function. In animal studies, atypical APDs have demonstrated to modulate dopamine (DA) and acetylcholine (Ach) neurotransmission preferentially in the cortical areas. Atypical APDs, unlike typical APDs,increase DA release in the prefrontal cortex to a greater extent than in the subcortical regions such as the striatum and nucleus accumbens, as measured by in vivo microdialysis. This preferential effect of atypical APDs may be related to their common receptor binding profiles such as greater affinities to serotonin (5-HT)2A receptors than DA-D2 receptors, in addition with significant ability to stimulate 5-HT1A receptors. Atypical APDs, but not typical APDs, also induce Ach release in the prefrontal cortex and hippocampus. Despite antagonism by some atypical APDs to muscarinic Ach receptors, these drugs may counteract it with an increase in Ach release. Thus, the greater ability of atypical APDs than typical APDs to enhance the release of DA and Ach in the cortical regions may be related to the neurocognitive effect of atypical APDs that are thought to ameliorate the hypofrontality responsible for cognitive deficits of schizophrenia.
참고문헌 (84)
- Heinrichs RW, "Neurocognitive deficit in schizophrenia: a quantitative review of the evidence", Neuropsychology, 12, pp.426~445 (1998)
- Palmer BW, "What do we know about neuropsychological aspects of schizophrenia?", Neuropsychol Rev, 19, pp.365~384 (2009)
- Dickinson D, "General and specific cognitive deficits in schizophrenia", Biol Psychiatry, 55, pp.826~833 (2004)
- Saykin AJ, "Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia", Arch Gen Psychiatry, 51, pp.124~131 (1994)
- Sitskoorn MM, "Memory profiles in parents of patients with schizophrenia", Psychiatry Res, 128, pp.27~37 (2004)
- Green MF, "What are the functional consequences of neurocognitive deficits in schizophrenia?", Am J Psychiatry, 153, pp.321~330 (1996)
- Velligan DI, "Do specific neurocognitive deficits predict specific domains of community function in schizophrenia?", J Nerv Ment Dis, 188, pp.518~524 (2000)
- Meltzer HY, "The effects of clozapine, risperidone and olanzapine on cognitive function in schizophrenia", Schizophr Bull, 25, pp.233~255 (1999)
- Keefe RS, "The effects of atypical antipsychotic drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis", Schizophr Bull, 25, pp.201~222 (1999)
- Harvey PD, "Studies of cognitive change in patients with schizophrenia following novel antipsychotic treatment", Am J Psychiatry, 158, pp.176~184 (2001)
- Weiss EM, "The effects of second-generation antipsychotics on cognitive functioning and psychosocial outcome in schizophrenia", Psychopharmacology (Berl), 162, pp.11~17 (2002)
- Woodward ND, "A metaanalysis of neuropsychological change to clozapine, olanzapine, quetiapine, and risperidone in schizophrenia", Int J Neuropsychopharmacol, 8, pp.457~472 (2005)
- Meltzer HY, "Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values", J Pharmacol Exp Ther, 251, pp.238~246 (1989)
- Kuroki T, "Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin-dopamine hypothesis", Prog Brain Res, 172, pp.199~212 (2008)
- Mishara AL, "A meta-analysis and critical review of the effects of conventional neuroleptic treatment on cognition in schizophrenia: opening a closed book", Biol Psychiatry, 55, pp.1013~1022 (2004)
- Woodward ND, "A metaanalysis of cognitive change with haloperidol in clinical trials of atypical antipsychotics: dose effects and comparison to practice effects", Schizophr Res, 89, pp.211~224 (2007)
- Harvey PD, "Treatment of cognitive impairment in early psychosis: a comparison of risperidone and haloperidol in a large long-term trial", Am J Psychiatry, 162, pp.1888~1895 (2005)
- Keefe RS, "HGDH Study Group. One-year double-blind study of the neurocognitive efficacy of olanzapine, risperidone, and haloperidol in schizophrenia", Schizophr Res, 81, pp.1~15 (2006)
- Keefe RS, "CATIE Investigators; Neurocognitive Working Group. Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial", Arch Gen Psychiatry, 64, pp.633~647 (2007)
- Davidson M, "Cognitive effects of antipsychotic drugs in first-episode schizophrenia and schizophreniform disorder: a randomized, open-label clinical trial (EUFEST)", Am J Psychiatry, 166, pp.675~682 (2009)
- Goldberg TE, "Cognitive improvement after treatment with second-generation antipsychotic medications in first-episode schizophrenia: is it a practice effect?", Arch Gen Psychiatry, 64, pp.1115~1122 (2007)
- Bilder RM, "Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder", Am J Psychiatry, 159, pp.1018~1028 (2002)
- Keefe RS, "Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison", Am J Psychiatry, 164, pp.1061~1071 (2007)
- Hoff AL, "The effects of clozapine on symptom reduction, neurocognitive function, and clinical management in treatment-refractory state hospital schizophrenic inpatients", Neuropsychopharmacology, 15, pp.361~369 (1996)
- Kane J, "Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine", Arch Gen Psychiatry, 45, pp.789~796 (1988)
- Harvey PD, "Negative symptoms and cognitive deficits: what is the nature of their relationship?", Schizophr Bull, 32, pp.250~258 (2006)
- Carpenter WT, "Another view of therapy for cognition in schizophrenia", Biol Psychiatry, 51, pp.969~971 (2002)
- Harvey PD, "Improvement in social competence with short-term atypical antipsychotic treatment: a randomized, double-blind comparison of quetiapine versus risperidone for social competence, social cognition, and neuropsychological functioning", Am J Psychiatry, 163, pp.1918~1925 (2006)
- Voruganti LP, "Cognition, functioning and quality of life in schizophrenia treatment: results of a one-year randomized controlled trial of olanzapine and quetiapine", Schizophr Res, 96, pp.146~155 (2007)
- Mohamed S, "Relationship of cognition and psychopathology to functional impairment in schizophrenia", Am J Psychiatry, 165, pp.978~987 (2008)
- Marder SR, "Measurement and treatment research to improve cognition in schizophrenia: NIMH MATRICS initiative to support the development of agents for improving cognition in schizophrenia", Schizophr Res, 72, pp.5~9 (2004)
- Green MF, "Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMHMATRICS conference to select cognitive domains and test criteria", Biol Psychiatry, 56, pp.301~307 (2004)
- Weinberger DR, "Prefrontal function in schizophrenia: confounds and controversies", Philos Trans R Soc Lond B Biol Sci, 351, pp.1495~1503 (1996)
- Keshavan MS, "Schizophrenia, "just the facts": what we know in 2008 Part 3: neurobiology", Schizophr Res, 106, pp.89~107 (2008)
- Lawrie SM, "Brain structure and function changes during the development of schizophrenia: the evidence from studies of subjects at increased genetic risk", Schizophr Bull, 34, pp.330~340 (2008)
- McGuire P, "Functional neuroimaging in schizophrenia: diagnosis and drug discovery", Trends Pharmacol Sci, 29, pp.91~98 (2008)
- Minzenberg MJ, "Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia", Arch Gen Psychiatry, 66, pp.811~822 (2009)
- Honey GD, "Differences in frontal cortical activation by a working memory task after substitution of risperidone for typical antipsychotic drugs in patients with schizophrenia", Proc Natl Acad Sci USA, 96, pp.13432~13437 (1999)
- Lahti AC, "Clozapine but not haloperidol Re- establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex", Neuropsychopharmacology, 29, pp.171~178 (2004)
- Snitz BE, "Lateral and medial hypofrontality in firstepisode schizophrenia: functional activity in a medicationnaive state and effects of short-term atypical antipsychotic treatment", Am J Psychiatry, 162, pp.2322~2329 (2005)
- Schotte A, "Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding", Psychopharmacology (Berl), 124, pp.57~73 (1996)
- Shapiro DA, "Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology", Neuropsychopharmacology, 28, pp.1400~1411 (2003)
- Leucht S, "Amisulpride, an unusual "atypical" antipsychotic: a meta-analysis of randomized controlled trials", Am J Psychiatry, 159, pp.180~190 (2002)
- Kapur S, "Does fast dissociation from the dopamine D2 receptor explain the action of atypical antipsychotics?: a new hypothesis", Am J Psychiatry, 158, pp.360~369 (2001)
- GTPγS binding study, "Eur J Pharmacol", 1998, 245~256
- Chou YH, "Occupancy of 5-HT1A receptors by clozapine in the primate brain: a PET study", Psychopharmacology (Berl), 166, pp.234~240 (2003)
- Mamo D, "Differential effects of aripiprazole on D2, 5-HT2, and 5-HT1A receptor occupancy in patients with schizophrenia: a triple tracer PET study", Am J Psychiatry, 164, pp.1411~1417 (2007)
- Araneda R, "Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediate opposing responses on membrane excitability in rat association cortex", Neuroscience, 40, pp.399~412 (1991)
- Moghaddam B, "Acute effects of typical and atypical antipsychotic drugs on the release of dopamine from prefrontal cortex, nucleus accumbens, and striatum of the rat: an in vivo microdialysis study", J Neurochem, 54, pp.1755~1760 (1990)
- VolontéM, "BIMG 80, a novel potential antipsychotic drug: evidence for multireceptor actions and preferential release of dopamine in prefrontal cortex", J Neurochem, 69, pp.182~190 (1997)
- Kuroki T, "Effects of antipsychotic drugs on extracellular dopamine levels in rat prefrontal cortex and nucleus accumbens", J Pharmacol Exp Ther, 288, pp.774~781 (1999)
- Youngren KD, "Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment", Neurosci Lett, 165, pp.41~44 (1994)
- Yamamoto BK, "Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations", J Neurosci, 14, pp.4159~4166 (1994)
- Youngren KD, "Clozapine preferentially increases dopamine release in the rhesus monkey prefrontal cortex compared with the caudate nucleus", Neuropsychopharmacology, 20, pp.403~412 (1999)
- Rollema H, "5-HT 1A receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex", Biol Psychiatry, 48, pp.229~237 (2000)
- Ichikawa J, "Atypical antipsychotic drugs, quetiapine, iloperidone, and melperone, preferentially increase dopamine and acetylcholine release in rat medial prefrontal cortex: role of 5-HT1A receptor agonism", Brain Res, 956, pp.349~357 (2002)
- Li Z, "Aripiprazole, a novel antipsychotic drug, preferentially increases dopamine release in the prefrontal cortex and hippocampus in rat brain", Eur J Pharmacol, 493, pp.75~83 (2004)
- Goldman-Rakic PS, "Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction", Psychopharmacology (Berl), 174, pp.3~16 (2004)
- Zahrt J, "Supranormal stimulation of D1 dopamine receptors in the rodent prefrontal cortex impairs spatial working memory performance", J Neurosci, 17, pp.8528~8535 (1997)
- Ichikawa J, "DOI, a 5-HT2A", 2C receptor agonist, attenuates clozapine-induced cortical dopamine release, 2001, pp.907, 151~155
- Ichikawa J, "5-HT2A and D2 receptor blockade increases cortical DA release via 5-HT1A receptor activation: a possible mechanism of atypical antipsychotic-induced cortical dopamine release", J Neurochem, 76, pp.1521~1531 (2001)
- Lié.geois JF, "5-HT2A receptor antagonism potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and inhibits that in the nucleus accumbens in a dose-dependent manner", Brain Res, 947, pp.157~165 (2002)
- Dí.az-Mataix L, "Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action", J Neurosci, 25, pp.10831~10843 (2005)
- Jordan S, "In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function", Eur J Pharmacol, 483, pp.45~53 (2004)
- Bortolozzi A, "In vivo actions of aripiprazole on serotonergic and dopaminergic systems in rodent brain", Psychopharmacology (Berl), 191, pp.745~758 (2007)
- Del Arco A, "Dopamine release in the prefrontal cortex during stress is reduced by the local activation of glutamate receptors", Brain Res Bull, 56, pp.125~130 (2001)
- Bleakman D, "Neuropharmacology of AMPA and kainate receptors", Neuropharmacology, 37, pp.1187~1204 (1998)
- Bymaster FP, "Radioreceptor binding profile of the atypical antipsychotic olanzapine", Neuropsychopharmacology, 14, pp.87~96 (1996)
- Michal P, "Clozapine interaction with the M2 and M4 subtypes of muscarinic receptors", Eur J Pharmacol, 376, pp.119~125 (1999)
- Gomeza J, "Enhancement of D1 dopamine receptormediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice", Proc Natl Acad Sci USA, 96, pp.10483~10488 (1999)
- Shekhar A, "Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia", Am J Psychiatry, 165, pp.1033~1039 (2008)
- Parada MA, "Selective action of acute systemic clozapine on acetylcholine release in the rat prefrontal cortex by reference to the nucleus accumbens and striatum", J Pharmacol Exp Ther, 281, pp.582~588 (1997)
- Ichikawa J, "Atypical, but not typical, antipsychotic drugs increase cortical acetylcholine release without an effect in the nucleus accumbens or striatum", Neuropsychopharmacology, 26, pp.325~339 (2002)
- Shirazi-Southall S, "Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat", Neuropsychopharmacology, 26, pp.583~594 (2002)
- Ichikawa J, "5-HT1A and 5-HT2A receptors minimally contribute to clozapine-induced acetylcholine release in rat medial prefrontal cortex", Brain Res, 939, pp.34~42 (2002)
- Sur C, "N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-Daspartate receptor activity", Proc Natl Acad Sci USA, 100, pp.13674~13679 (2003)
- Natesan S, "Kapur S. Evaluation of N-desmethylclozapine as a potential antipsychotic-- preclinical studies", Neuropsychopharmacology, 32, pp.1540~1549 (2007)
- Lameh J, "Pharmacology of N-desmethylclozapine", Pharmacol Ther, 115, pp.223~231 (2007)
- Li Z, "N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors", Neuropsychopharmacology, 30, pp.1986~1995 (2005)
- Burstein ES, "Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2", D3 partial agonist, 2005, pp.315, 1278~1287
- Onali P, "N-desmethylclozapine, a major clozapine metabolite, acts as a selective and efficacious deltaopioid agonist at recombinant and native receptors", Neuropsychopharmacology, 32, pp.773~785 (2007)
- Weiner DM, "The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine", Psychopharmacology (Berl), 177, pp.207~216 (2004)
- Sumiyoshi T, "Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study", Schizophr Res, 95, pp.158~168 (2007)
- Goff DC, "A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia", Neuropsychopharmacology, 33, pp.465~472 (2008)
