The Impact of Weight Changes on Nonalcoholic Fatty Liver Disease in Adult Men with Normal Weight
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Although it is known that losing weight has an effect on the treatment of non-alcoholic fatty liver disease, the studies that show how losing weight affects the non-alcoholic fatty liver disease for the normal weight male adults are limited so far. In this study, we set body mass index as criteria and investigated how the weight changes for 4 years makes an impact on the risk of non-alcoholic fatty liver disease for the male adults who have the normal body mass index.Methods: From January to December of 2004, among the normal weight male adults who had general check-up at the Health Promotion Center of Ulsan University Hospital, 180 people (average age, 47.4 ± 4.61 years) who were diagnosed with fatty liver through abdominal ultrasonography were included in this study and were observed according to the variety of data and ultrasonography after 4 years (2008). People who had a history of drinking more than 140 g of alcohol per week or who had a past medical history were excluded from the analysis. The weight change of subjects was calculated using the formula ‘weight change = weight of 2008 (kg) - weight of 2004 (kg)’ and classified into three groups, loss group (≤-3.0 kg), stable group (-2.9 to 2.9 kg), and gain group (≥3.0 kg). The odds for disappearance of non-alcoholic fatty liver disease in those three different groups were compared.Results: Among 180 subjects, compared with stable group (67.2%, 121 subjects), loss group (11.7%, 21 subjects) showed 18.37-fold increase in the odds of disappearance of non-alcoholic fatty liver disease (95% confidence interval [CI], 4.34 to 77.80) and gain group (21.1%, 38 subjects) showed 0.28-fold decrease in the odds of disappearance of non-alcoholic fatty liver disease (95% CI, 0.10 to 0.83).Conclusion: Even for the normal weight people, losing weight has an effect on the improvement of non-alcoholic fatty liver disease.
Abstract
Background: Although it is known that losing weight has an effect on the treatment of non-alcoholic fatty liver disease, the studies that show how losing weight affects the non-alcoholic fatty liver disease for the normal weight male adults are limited so far. In this study, we set body mass index as criteria and investigated how the weight changes for 4 years makes an impact on the risk of non-alcoholic fatty liver disease for the male adults who have the normal body mass index.Methods: From January to December of 2004, among the normal weight male adults who had general check-up at the Health Promotion Center of Ulsan University Hospital, 180 people (average age, 47.4 ± 4.61 years) who were diagnosed with fatty liver through abdominal ultrasonography were included in this study and were observed according to the variety of data and ultrasonography after 4 years (2008). People who had a history of drinking more than 140 g of alcohol per week or who had a past medical history were excluded from the analysis. The weight change of subjects was calculated using the formula ‘weight change = weight of 2008 (kg) - weight of 2004 (kg)’ and classified into three groups, loss group (≤-3.0 kg), stable group (-2.9 to 2.9 kg), and gain group (≥3.0 kg). The odds for disappearance of non-alcoholic fatty liver disease in those three different groups were compared.Results: Among 180 subjects, compared with stable group (67.2%, 121 subjects), loss group (11.7%, 21 subjects) showed 18.37-fold increase in the odds of disappearance of non-alcoholic fatty liver disease (95% confidence interval [CI], 4.34 to 77.80) and gain group (21.1%, 38 subjects) showed 0.28-fold decrease in the odds of disappearance of non-alcoholic fatty liver disease (95% CI, 0.10 to 0.83).Conclusion: Even for the normal weight people, losing weight has an effect on the improvement of non-alcoholic fatty liver disease.
참고문헌 (20)
- Bugianesi E, "Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma", Gastroenterology, 123, pp.134~140 (2002)
- Angelico F, "Non-alcoholic fatty liver syndrome: a hepatic consequence of common metabolic diseases", J Gastroenterol Hepatol, 18, pp.588~594 (2003)
- Bayard M, "Nonalcoholic fatty liver disease", Am Fam Physician, 73, pp.1961~1968 (2006)
- Clark JM, "The epidemiology of nonalcoholic fatty liver disease in adults", J Clin Gastroenterol, 40(Suppl 1), pp.S5~S10 (2006)
- American Gastroenterological Association, "American Gastroenterological Association medical position statement: nonalcoholic fatty liver disease", Gastroenterology, 123, pp.1702~1704 (2002)
- Sanyal AJ, "American Gastroenterological Association. AGA technical review on nonalcoholic fatty liver disease", Gastroenterology, 123, pp.1705~1725 (2002)
- Ueno T, "Therapeutic effects of restricted diet and exercise in obese patients with fatty liver", J Hepatol, 27, pp.103~107 (1997)
- Harrison SA, "A pilot study of orlistat treatment in obese, non-alcoholic steatohepatitis patients", Aliment Pharmacol Ther, 20, pp.623~628 (2004)
- Sheth SG, "Natural history and management of nonalcoholic fatty liver disease in adults" (2014), UpToDate
- Hsieh SD, "Health risks among Japanese men with moderate body mass index", Int J Obes Relat Metab Disord, 24, pp.358~362 (2000)
- Mittelstaedt CA, "General ultrasound" (1992), Churchill Livingstone
- Hickman IJ, "Modest weight loss and physical activity in overweight patients with chronic liver disease results in sustained improvements in alanine aminotransferase, fasting insulin, and quality of life", Gut, 53, pp.413~419 (2004)
- Dixon JB, "Nonalcoholic fatty liver disease: improvement in liver histological analysis with weight loss", Hepatology, 39, pp.1647~1654 (2004)
- Petersen KF, "Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes", Diabetes, 54, pp.603~608 (2005)
- Promrat K, "Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis", Hepatology, 51, pp.121~129 (2010)
- Keating SE, "Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis", J Hepatol, 57, pp.157~166 (2012)
- Jin YJ, "Exercise and diet modification in non-obese non-alcoholic fatty liver disease: Analysis of biopsies of living liver donors", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 27, pp.1341~1347 (2012), BLACKWELL PUBLISHING
- Liu CJ, "Prevalence and risk factors for non-alcoholic fatty liver disease in Asian people who are not obese", J Gastroenterol Hepatol, 27, pp.1555~1560 (2012)
- Chalasani N, "The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology", Gastroenterology, 142, pp.1592~1609 (2012)
- Lewis JR, "Nonalcoholic fatty liver disease: a review and update", Dig Dis Sci, 55, pp.560~578 (2010)