Multiple Neuroendocrine Tumors in Stomach and Duodenum in a Multiple Endocrine Neoplasia Type 1 Patient
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous examination of the entire stomach and duodenum revealed multiple scattered, minute neuroendocrine tumors. To the best of our knowledge, this is the first case report of a patient diagnosed with gastroduodenal neuroendocrine tumors associated with multiple endocrine neoplasia type 1 (MEN 1) in whom complete histologic mapping of the whole gastrectomy specimen was performed. The presence of MEN 1–associated neuroendocrine tumors in the stomach is very rare, but should be considered in patients diagnosed with MEN 1 who present with a new tumor in the stomach.
Abstract
A 67-year-old woman with a history of subtotal parathyroidectomy, distal pancreatectomy, and total splenectomy 23 years prior underwent surgical gastric resection for neuroendocrine tumors of the stomach and duodenum. Meticulous examination of the entire stomach and duodenum revealed multiple scattered, minute neuroendocrine tumors. To the best of our knowledge, this is the first case report of a patient diagnosed with gastroduodenal neuroendocrine tumors associated with multiple endocrine neoplasia type 1 (MEN 1) in whom complete histologic mapping of the whole gastrectomy specimen was performed. The presence of MEN 1–associated neuroendocrine tumors in the stomach is very rare, but should be considered in patients diagnosed with MEN 1 who present with a new tumor in the stomach.
참고문헌 (12)
- Kouvaraki MA, "Genotype-phenotype analysis in multiple endocrine neoplasia type 1", Arch Surg, 137, pp.641~647 (2002)[DOI]
- de Laat JM, "MEN1 redefined, a clinical comparison of mutation-positive and mutation-negative patients", BMC Med, 14, pp.182~ (2016)[DOI]
- Thakker RV, "Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)", Mol Cell Endocrinol, 386, pp.2~15 (2014)[DOI]
- Feliberti E, "Endotext" (2000), MDText.com Inc
- Turner JJ, "Diagnostic challenges due to phenocopies: lessons from multiple endocrine neoplasia type1 (MEN1)", Hum Mutat, 31, pp.E1089~E1101 (2010)[DOI]
- Grin A, "Neuroendocrine tumors of the luminal gastrointestinal tract", Arch Pathol Lab Med, 139, pp.750~756 (2015)[DOI]
- Wang GG, "Comparison of genetic alterations in neuroendocrine tumors: frequent loss of chromosome 18 in ileal carcinoid tumors", Mod Pathol, 18, pp.1079~1087 (2005)[DOI]
- Christopoulos C, "Gastric neuroendocrine tumors: biology and management", Ann Gastroenterol, 18, pp.127~140 (2005)
- Falchetti A, "Genetic screening for multiple endocrine neoplasia syndrome type 1 (MEN-1): when and how", F1000 Med Rep, 2, pp.14~ (2010)
- Tsikitis VL, "Trends of incidence and survival of gastrointestinal neuroendocrine tumors in the United States: a seer analysis", J Cancer, 3, pp.292~302 (2012)[DOI]
- Li TT, "Classification, clinicopathologic features and treatment of gastric neuroendocrine tumors", World J Gastroenterol, 20, pp.118~125 (2014)[DOI]
- Sato Y, "Management of gastric and duodenal neuroendocrine tumors", World J Gastroenterol, 22, pp.6817~6828 (2016)[DOI]