Downregulated CDK10 promotes cancer progression and radioresistance in lung cancer through activating the JNK/c-Jun signaling pathway
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Lung cancer is one of the most significant malignancies, withboth high morbidity and mortality. CDK10 is closely related tocancer progression and metastasis. However, its role in lungcancer radioresistance demands further clarification. In this study,we demonstrated that CDK10 was downregulated in lung cancertissues, and CDK10 expression level was associated withthe clinical prognosis in lung cancer patients. We also foundthat silencing CDK10 promoted lung cancer cell proliferation,migration, and radioresistance. We further verified that silencingCDK10 facilitated the activation of JNK/c-Jun signaling, and c-Jundepletion could reverse the effects of CDK10 knockdown inlung cancer cells. Our findings revealed that CDK10 plays animportant role in cell growth and radioresistance by inhibitingJNK/c-Jun signaling pathway in lung cancer. Therefore, CDK10might be a promising therapeutic target in lung cancer.
Abstract
Lung cancer is one of the most significant malignancies, withboth high morbidity and mortality. CDK10 is closely related tocancer progression and metastasis. However, its role in lungcancer radioresistance demands further clarification. In this study,we demonstrated that CDK10 was downregulated in lung cancertissues, and CDK10 expression level was associated withthe clinical prognosis in lung cancer patients. We also foundthat silencing CDK10 promoted lung cancer cell proliferation,migration, and radioresistance. We further verified that silencingCDK10 facilitated the activation of JNK/c-Jun signaling, and c-Jundepletion could reverse the effects of CDK10 knockdown inlung cancer cells. Our findings revealed that CDK10 plays animportant role in cell growth and radioresistance by inhibitingJNK/c-Jun signaling pathway in lung cancer. Therefore, CDK10might be a promising therapeutic target in lung cancer.
참고문헌 (31)
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