N-Adamantyl-4-methylthiazol-2-amine suppresses glutamate-induced autophagic cell death via PI3K/Akt/mTOR signaling pathways in cortical neurons

키워드

참고문헌 (34)

1. Blandini F, "The role of glutamate in the pathophysiology of Parkinson’s disease", Funct Neurol, 11, pp.3~15 (1996)
2. Olney JW, "Excitotoxicity, apoptosis and neuropsychiatric disorders", Curr Opin Pharmacol, 3, pp.101~109 (2003)
3. Kalia LV, "NMDA receptors in clinical neurology : excitatory times ahead", Lancet Neurol, 7, pp.742~755 (2008)
4. Patel M, "Requirement for superoxide in excitotoxic cell death", Neuron, 16, pp.345~355 (1996)
5. Halliwell B, "Oxidative stress and neurodegeneration:where are we now?", J Neurochem, 97, pp.1634~1658 (2006)
6. Margaill I, "Antioxidant strategies in the treatment of stroke", Free Radic Biol Med, 39, pp.429~443 (2005)
7. Havsteen BH, "The biochemistry and medical significance of the flavonoids", Pharmacol Ther, 96, pp.67~202 (2002)
8. Bigford GE, "A novel protein complex in membrane rafts linking the NR2B glutamate receptor and autophagy is disrupted following traumatic brain injury", J Neurotrauma, 26, pp.703~720 (2009)
9. Kulbe JR, "Excitotoxic glutamate insults block autophagic flux in hippocampal neurons", Brain Res, 1542, pp.12~19 (2016)
10. Wang Y, "Autophagy regulates inflammation following oxidative injury in diabetes", Autophagy, 9, pp.272~277 (2013)
11. Kim EA, "Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells", Int Immunopharmacol, 22, pp.73~83 (2014)
12. Chen ZF, "The double-edged effect of autophagy in pancreatic beta cells and diabetes", Autophagy, 7, pp.12~16 (2011)
13. Kim H, "Activation of autophagy during glutamate-induced HT22 cell death", Biochem Biophys Res Commun, 388, pp.339~344 (2009)
14. Ma YM, "Selenium suppresses glutamate‑induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells", BMC Neurosci, 18, pp.15~ (2017)
15. Kumari S, "Glutamate Induces Mitochondrial Dynamic Imbalance and Autophagy Activation : Preventive Effects of Selenium", PLoS One, 7, pp.e39382~ (2012)
16. Yang SJ, "Effects of Nadamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats", Eur J Pharmacol, 736, pp.26~34 (2014)
17. Cho CH, "N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons", Free Rad Res, 50, pp.678~690 (2016)
18. Cho CH, "N-Adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice", J Neuroimmunol, 289, pp.98~104 (2015)
19. Yang SJ, "N-Adamantyl-4-methylthiazol-2-amine attenuates glutamate-induced oxidative stress and inflammation in the brain", Neurotox Res, 32, pp.107~120 (2017)
20. Xing S, "Beclin 1 knockdown inhibits autophagic activation and prevents the secondary neurodegenerative damage in the ipsilateral thalamus following focal cerebral infarction", Autophagy, 8, pp.63~76 (2012)
21. Yin WY, "Salidroside protects cortical neurons against glutamate-induced cytotoxicity by inhibiting autophagy", Mol Cell Biochem, 419, pp.53~64 (2016)
22. Ichimura Y, "Selective turnover of p62", A170, Autophagy, pp.2008, 4[DOI]
23. Yang Z, "Mammalian autophagy : core molecular machinery and signaling regulation", Curr Opin Cell Biol, 22, pp.124~131 (2012)
24. Wang Y, "IGF-1 alleviates NMDA-induced excitotoxicity in cultured hippocampal neurons against autophagy via the NR2B", PI3K-AKT-mTOR pathway, 2014, pp.229, 1618~1629
25. Wu YT, "Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy", Autophagy, 5, pp.824~834 (2009)
26. Saiki S, "Caffeine induces apoptosis by enhancement of autophagy via PI3K", Akt, p70S6K inhibition, pp.Autophagy, 2011[DOI]
27. Peltier J, "PI3K", Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation, 2007, pp.67, 1348~1361
28. Harris H, "Control of autophagy as a therapy for neurodegenerative disease", Nat Rev Neurol, 8, pp.108~117 (2012)
29. Qureshi GA, "Neurotoxicity, oxidative stress and cerebrovascular disorders", Neurotoxicol, 25, pp.121~138 (2004)
30. Ma S, "Neuroprotective effect of ginkgolide K on glutamate-induced cytotoxicity in PC 12cells via inhibition of ROS generation and Ca2+ influx", Neurotoxicol, 33, pp.59~69 (2012)
31. Nie BM, "Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity", Neuropharmacology, 54, pp.845~853 (2008)
32. Lombardi G, "Cabergoline prevents necrotic neuronal death in an in vitro model of oxidative stress", Eur J Pharmacol, 457, pp.95~99 (2002)
33. Rattanajarasroj S, "Comparable attenuation of Abeta(25-35)-induced neurotoxicity by quercitrin and 17 beta-estradiol in cultured rat hippocampal neurons", Neurochem Res, 35, pp.1196~1205 (2010)
34. 한아름, "Protective effects of N,4,5-trimethylthiazol-2-amine hydrochloride on hypoxia-induced β-amyloid production in SH-SY5Y cells", BMB Reports, 52(7), pp.439~444 (2019), 생화학분자생물학회[DOI]

관련 논문AI추천