Neurorestoration Induced by Mesenchymal Stem Cells: Potential Therapeutic Mechanisms for Clinical Trials
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Stem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood or adipose tissue, comprise a population of cells that exhibit extensive proliferative potential and retain the ability to differentiate into multiple tissue-specific lineage cells including osteoblasts, chondrocytes,and adipocytes. MSCs have also been shown to enhance neurological recovery,although the therapeutic effects seem to be derived from an indirect paracrine effect rather than direct cell replacement. MSCs secrete neurotrophic factors, promote endogenous neurogenesis and angiogenesis, encourage synaptic connection and remyelination of damaged axons, decrease apoptosis, and regulate inflammation primarily through paracrine actions. Accordingly, MSCs may prevail as a promising cell source for cell-based therapy in neurological diseases.
Abstract
Stem cells are emerging as therapeutic candidates in a variety of diseases because of their multipotent capacities. Among these, mesenchymal stem cells (MSCs) derived from bone marrow, umbilical cord blood or adipose tissue, comprise a population of cells that exhibit extensive proliferative potential and retain the ability to differentiate into multiple tissue-specific lineage cells including osteoblasts, chondrocytes,and adipocytes. MSCs have also been shown to enhance neurological recovery,although the therapeutic effects seem to be derived from an indirect paracrine effect rather than direct cell replacement. MSCs secrete neurotrophic factors, promote endogenous neurogenesis and angiogenesis, encourage synaptic connection and remyelination of damaged axons, decrease apoptosis, and regulate inflammation primarily through paracrine actions. Accordingly, MSCs may prevail as a promising cell source for cell-based therapy in neurological diseases.
참고문헌 (89)
- Gogel S, "Progress and prospects: stem cells and neurological diseases", Gene Ther, 18, pp.1~6 (2011)
- Lovell-Badge R, "The regulation of human embryo and stem-cell research in the United Kingdom", Nat Rev Mol Cell Biol, 9, pp.998~1003 (2008)
- Mathews DJ, "Cell-based interventions for neurologic conditions: ethical challenges for early human trials", Neurology, 71, pp.288~293 (2008)
- Uccelli A, "Mesenchymal stem cells for the treatment of multiple sclerosis and other neurological diseases", Lancet Neurol, 10, pp.649~656 (2011)
- Martino G, "The therapeutic potential of neural stem cells", Nat Rev Neurosci, 7, pp.395~406 (2006)
- Erices AA, "Human cord blood-derived mesenchymal stem cells home and survive in the marrow of immunodeficient mice after systemic infusion", Cell Transplant, 12, pp.555~561 (2003)
- De Bari C, "Multipotent mesenchymal stem cells from adult human synovial membrane", Arthritis Rheum, 44, pp.1928~1942 (2001)
- Fukumoto T, "Combined effects of insulin-like growth factor-1 and transforming growth factor-beta1 on periosteal mesenchymal cells during chondrogenesis in vitro", Osteoarthritis Cartilage, 11, pp.55~64 (2003)
- Villaron EM, "Mesenchymal stem cells are present in peripheral blood and can engraft after allogeneic hematopoietic stem cell transplantation", Haematologica, 89, pp.1421~1427 (2004)
- Zuk PA, "Multilineage cells from human adipose tissue: implications for cell-based therapies", Tissue Eng, 7, pp.211~228 (2001)
- Cao B, "Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential", Nat Cell Biol, 5, pp.640~646 (2003)
- Parolini O, "Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells", Stem Cells, 26, pp.300~311 (2008)
- Sekiya I, "Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality", Stem Cells, 20, pp.230~241 (2002)
- Pittenger MF, "Multilineage potential of adult human mesenchymal stem cells", Science, 284, pp.143~147 (1999)
- Phinney DG, "Concise review: mesenchymal stem", multipotent stromal cells: the state of transdifferentiation and modes of tissue repair--current views, 2007, pp.25, 2896~2902
- 이명우, "Isolation of mesenchymal stem cells from cryopreserved human umbilical cord blood", INTERNATIONAL JOURNAL OF HEMATOLOGY, 81, pp.126~130, SPRINGER TOKYO
- Kotobuki N, "Cultured autologous human cells for hard tissue regeneration: preparation and characterization of mesenchymal stem cells from bone marrow", Artif Organs, 28, pp.33~39 (2004)
- Dazzi F, "The role of mesenchymal stem cells in haemopoiesis", Blood Rev, 20, pp.161~171 (2006)
- Rasmusson I, "Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells", Transplantation, 76, pp.1208~1213 (2003)
- DelaRosa O, "Modulation of adult mesenchymal stem cells activity by toll-like receptors: implications on therapeutic potential", Mediators Inflamm, 2010, pp.865601~ (2010)
- Le Blanc K, "HLA expression and immunologic properties of differentiated and undifferentiated mesenchymal stem cells", Exp Hematol, 31, pp.890~896 (2003)
- Caplan AI, "Mesenchymal stem cells as trophic mediators", J Cell Biochem, 98, pp.1076~1084 (2006)
- Bernardo ME, "Mesenchymal stromal cells", Ann N Y Acad Sci, 1176, pp.101~117 (2009)
- Vemuri MC, "Mesenchymal stem cell assays and applications", Methods Mol Biol, 698, pp.3~8 (2011)
- Keum Seok Bae, "Neuron-Like Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells", Yonsei Medical Journal, 52(3), pp.401~412 (2011), 연세대학교의과대학
- Horwitz EM, "Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement", Cytotherapy, 7, pp.393~395 (2005)
- Bianco P, "Postnatal skeletal stem cells", Methods Enzymol, 419, pp.117~148 (2006)
- Laflamme MA, "Regenerating the heart", Nat Biotechnol, 23, pp.845~856 (2005)
- Chen J, "Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat", J Neurosci Res, 73, pp.778~786 (2003)
- Li Y, "Gliosis and brain remodeling after treatment of stroke in rats with marrow stromal cells", Glia, 49, pp.407~417 (2005)
- Murphy JM, "Stem cell therapy in a caprine model of osteoarthritis", Arthritis Rheum, 48, pp.3464~3474 (2003)
- Rosová I, "Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells", Stem Cells, 26, pp.2173~2182 (2008)
- Nagai A, "Multilineage potential of stable human mesenchymal stem cell line derived from fetal marrow", PLoS One, 2, pp.1272~ (2007)
- Li Y, "Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery", Neurology, 59, pp.514~523 (2002)
- Qu R, "Neurotrophic and growth factor gene expression profiling of mouse bone marrow stromal cells induced by ischemic brain extracts", Neuropathology, 27, pp.355~363 (2007)
- Cho SR, "Neurally induced umbilical cord blood cells modestly repair injured spinal cords", Neuroreport, 19, pp.1259~1263
- Yoo SW, "Mesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model", Experimental and Molecular Medicine, 40(4), pp.387~397 (2008), 생화학분자생물학회
- Kopen GC, "Marrow stromal cells migrate throughout forebrain and cerebellum, and they differentiate into astrocytes after injection into neonatal mouse brains", Proc Natl Acad Sci U S A, 96, pp.10711~10716 (1999)
- Kim SS, "Neural induction with Neurogenin1 increases the therapeutic effects of mesenchymal stem cells in the ischemic brain", STEM CELLS, 26, pp.2217~2228, ALPHAMED PRESS
- Maltman DJ, "Role of mesenchymal stem cells in neurogenesis and nervous system repair", Neurochem Int, 59, pp.347~356 (2011)
- Sakai T, "Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis", Nat Med, 7, pp.324~330 (2001)
- Giger RJ, "Guidance molecules in axon regeneration", Cold Spring Harb Perspect Biol, 2, pp.a001867~ (2010)
- Akiyama Y, "Remyelination of the spinal cord following intravenous delivery of bone marrow cells", Glia, 39, pp.229~236 (2002)
- Satake K, "Migration of mesenchymal stem cells through cerebrospinal fluid into injured spinal cord tissue", Spine, 29, pp.1971~1979 (2004)
- Uccelli A, "Mesenchymal stem cells in health and disease", Nat Rev Immunol, 8, pp.726~736 (2008)
- Zappia E, "Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy", Blood, 106, pp.1755~1761 (2005)
- Gerdoni E, "Mesenchymal stem cells effectively modulate pathogenic immune response in experimental autoimmune encephalomyelitis", Ann Neurol, 61, pp.219~227 (2007)
- Kim YJ, "Neuroprotective Effects of Human Mesenchymal Stem Cells on Dopaminergic Neurons Through Anti-Inflammatory Action", GLIA, 57(1), pp.13~23, WILEY-LISS
- Chao YX, "Mesenchymal stem cell transplantation attenuates blood brain barrier damage and neuroinflammation and protects dopaminergic neurons against MPTP toxicity in the substantia nigra in a model of Parkinson’s disease", J Neuroimmunol, 216, pp.39~50 (2009)
- Ohtaki H, "Stem", progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory, Proc Natl Acad Sci U S A, pp.2008, 105[DOI]
- Seo JH, "Immunomodulation from intravenous transplantation of mesenchymal stem cells promotes functional recovery in spinal cord injured rats", Cell Med, 2, pp.55~67 (2011)
- Gnecchi M, "Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement", FASEB J, 20, pp.661~669 (2006)
- Cai L, "Suppression of hepatocyte growth factor production impairs the ability of adipose-derived stem cells to promote ischemic tissue revascularization", Stem Cells, 25, pp.3234~3243 (2007)
- Nakagami H, "Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells", Arterioscler Thromb Vasc Biol, 25, pp.2542~2547 (2005)
- Rehman J, "Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells", Circulation, 109, pp.1292~1298 (2004)
- Sadat S, "The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF", Biochem Biophys Res Commun, 363, pp.674~679 (2007)
- Miranville A, "Improvement of postnatal neovascularization by human adipose tissue-derived stem cells", Circulation, 110, pp.349~355 (2004)
- Crigler L, "Human mesenchymal stem cell subpopulations express a variety of neuro-regulatory molecules and promote neuronal cell survival and neuritogenesis", Exp Neurol, 198, pp.54~64 (2006)
- Cho SR, "Functional recovery after the transplantation of neurally differentiated mesenchymal stem cells derived from bone barrow in a rat model of spinal cord injury", Cell Transplant, 18, pp.1359~1368 (2009)
- Cho HJ, "Role of host tissues for sustained humoral effects after endothelial progenitor cell transplantation into the ischemic heart", J Exp Med, 204, pp.3257~3269 (2007)
- Tateno K, "Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization", Circ Res, 98, pp.1194~1202 (2006)
- Si YL, "MSCs: biological characteristics, clinical applications and their outstanding concerns", Ageing Res Rev, 10, pp.93~103 (2011)
- Koc ON, "Mesenchymal stem cells: heading into the clinic", Bone Marrow Transplant, 27, pp.235~239 (2001)
- Horwitz EM, "Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone", Proc Natl Acad Sci U S A, 99, pp.8932~8937 (2002)
- Dimmeler S, "Unchain my heart: the scientific foundations of cardiac repair", J Clin Invest, 115, pp.572~583 (2005)
- Loebinger MR, "Mesenchymal stem cell delivery of TRAIL can eliminate metastatic cancer", Cancer Res, 69, pp.4134~4142 (2009)
- Aguayo-Mazzucato C, "Stem cell therapy for type 1 diabetes mellitus", Nat Rev Endocrinol, 6, pp.139~148 (2010)
- Pistoia V, "Potential of mesenchymal stem cells for the therapy of autoimmune diseases", Expert Rev Clin Immunol, 6, pp.211~218 (2010)
- Minger SL, "Endogenous neurogenesis in the human brain following cerebral infarction", Regen Med, 2, pp.69~74 (2007)
- Ekonomou A, "Increased neural progenitors in vascular dementia", Neurobiol Aging, 32, pp.2152~2161 (2011)
- Bang OY, "Autologous mesenchymal stem cell transplantation in stroke patients", Ann Neurol, 57, pp.874~882 (2005)
- Lee JS, "STARTING collaborators. A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke", Stem Cells, 28, pp.1099~1106 (2010)
- Zhang ZX, "A combined procedure to deliver autologous mesenchymal stromal cells to patients with traumatic brain injury", Cytotherapy, 10, pp.134~139 (2008)
- Joyce N, "Mesenchymal stem cells for the treatment of neurodegenerative disease", Regen Med, 5, pp.933~946 (2010)
- Schwab ME, "Repairing the injured spinal cord", Science, 295, pp.1029~1031 (2002)
- Sahni V, "Stem cell therapies for spinal cord injury", Nat Rev Neurol, 6, pp.363~372 (2010)
- Geffner LF, "Administration of autologous bone marrow stem cells into spinal cord injury patients via multiple routes is safe and improves their quality of life: comprehensive case studies", Cell Transplant, 17, pp.1277~1293 (2008)
- Syková E, "Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury", Cell Transplant, 15, pp.675~687 (2006)
- Pal R, "Ex vivo-expanded autologous bone marrow-derived mesenchymal stromal cells in human spinal cord injury", paraplegia: a pilot clinical study, 2009, pp.11, 897~911
- Ra JC, "Safety of intravenous infusion of human adipose tissue-derived mesenchymal stem cells in animals and humans", Stem Cells Dev, 20, pp.1297~1308 (2011)
- Li JY, "Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation", Nat Med, 14, pp.501~503 (2008)
- Venkataramana NK, "Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson’s disease", Transl Res, 155, pp.62~70 (2010)
- Lee PH, "Autologous mesenchymal stem cell therapy delays the progression of neurological deficits in patients with multiple system atrophy", Clin Pharmacol Ther, 83, pp.723~730 (2008)
- Nagano I, "Beneficial effects of intrathecal IGF-1 administration in patients with amyotrophic lateral sclerosis", Neurol Res, 27, pp.768~772 (2005)
- Karussis D, "Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis", Arch Neurol, 67, pp.1187~1194 (2010)
- Mazzini L, "Stem cell treatment in Amyotrophic Lateral Sclerosis", J Neurol Sci, 265, pp.78~83 (2008)
- Mazzini L, "Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial", Exp Neurol, 223, pp.229~237 (2010)
- Mohyeddin Bonab M, "Does mesenchymal stem cell therapy help multiple sclerosis patients? Report of a pilot study", Iran J Immunol, 4, pp.50~57 (2007)
- Yamout B, "Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study", J Neuroimmunol, 227, pp.185~189 (2010)
