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외상 후 스트레스 장애 환자의 혈청 테스토스테론치

Serum Testosterone Levels in Patients with Post-Traumatic Stress Disorder

강석훈|방유진|김동수|김해정|고창민|정문용
대한불안의학회 (Korean Academy of Anxiety Disorders)|2013.10|대한불안의학회지 (Anxiety and Mood)|제9권 제2호|pp. 106-112

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참고문헌

키워드

외상 후 스트레스 장애·시상하부-뇌하수체-생식선 축·테스토스테론.Post-traumatic stress disorder·Hypothalamic-pituitary-gonadal axis·Testosterone.
주제분류정신과학

초록

Abstract

Objective : Several reports have found abnormal levels of androgen in post-traumatic stress disorder (PTSD) patients. This abnormality in androgen is hypothesized to due to chronic psychological stress effects on the hypothalamic-pituitary-gonadal (HPG) system. The present study was conducted to estimate serum testosterone levels in PTSD patients in comparison with normal subjects. Methods : Seventy-five male Korean veterans of the Vietnam War volunteered for the study, of which eleven were excluded because of incomplete psychological assessment. To measure basal serum testosterone, blood samples were collected between 8.00 and 9.30 a.m. The clinician administered PTSD scale (CAPS), the structured clinical interview for DSM-IV (SCID), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Mini International Neuropsychiatric Interview Plus (Korean version of MINI-Plus), CES-K (Korean version of combat exposure scale). Results : The serum testosterone level of PTSD patients (5.4±2.5 ng/mL) was higher than that of a control group (3.1±1.7 ng/mL, p＜0.001). Testosterone levels were significantly correlated with CAPS (r=.38, p＜.01), HAM-A (r=.35, p＜.01) and HAM-D (r=.28, p＜.01) in all subjects. Conclusion : The results of the present study suggest that chronic psychological stress affects the HPG system.

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