An Open-Label, Split-Face Trial Evaluating Efficacy and Safty of Photopneumatic Therapy for the Treatment of Acne
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Acne vulgaris is the most common skin disease worldwide, with many available treatment modalities,including oral and topical medications and laser therapy. Recently, a novel device (Isolaz, Pleasanton, CA, USA) that combines vacuum pressure and a broadband light source (400 nm to 1,200 nm) was developed for the treatment of acne. Objective: To determine the clinical efficacy and safety of photopneumatic therapy for the treatment of acne vulgaris of the face. Methods: Twenty adults with mild to moderate facial acne vulgaris received 4 successive treatments on one side of the face with a combined photopneumatic device (intense pulsed light: fluence=5.8 J/cm2; negative pressure=iMP mode) at 2 week intervals. Acne lesions on the opposite side of the face were not treated. Lesion counts were performed at baseline, prior to each treatment session, and at 3 months after the final treatment session. Results:Significant lesion improvements and reduced numbers of acne lesions were observed on the treated side of the faces. Most patients experienced global clinical improvement. No severe side effects occurred during the study, with only a few patients experiencing transient erythema, purpura and/or exacerbation of pre-existing acne. Conclusion: Photopneumatic therapy is a safe and effective treatment for mild to moderate acne vulgaris.
Abstract
Background: Acne vulgaris is the most common skin disease worldwide, with many available treatment modalities,including oral and topical medications and laser therapy. Recently, a novel device (Isolaz, Pleasanton, CA, USA) that combines vacuum pressure and a broadband light source (400 nm to 1,200 nm) was developed for the treatment of acne. Objective: To determine the clinical efficacy and safety of photopneumatic therapy for the treatment of acne vulgaris of the face. Methods: Twenty adults with mild to moderate facial acne vulgaris received 4 successive treatments on one side of the face with a combined photopneumatic device (intense pulsed light: fluence=5.8 J/cm2; negative pressure=iMP mode) at 2 week intervals. Acne lesions on the opposite side of the face were not treated. Lesion counts were performed at baseline, prior to each treatment session, and at 3 months after the final treatment session. Results:Significant lesion improvements and reduced numbers of acne lesions were observed on the treated side of the faces. Most patients experienced global clinical improvement. No severe side effects occurred during the study, with only a few patients experiencing transient erythema, purpura and/or exacerbation of pre-existing acne. Conclusion: Photopneumatic therapy is a safe and effective treatment for mild to moderate acne vulgaris.
참고문헌 (9)
- William DJ, "Andrews’ diseases of the skin. 10th ed", pp.231~239 (2006), WB Saunders
- Collier CN, "The prevalence of acne in adults 20 years and older", J Am Acad Dermatol, 58, pp.56~59 (2008)
- Kawana S, "Effect of smooth pulsed light at 400 to 700 and 870 to 1,200 nm for acne vulgaris in Asian skin", Dermatol Surg, 36, pp.52~57 (2010)
- Shamban AT, "Photopneumatic technology for the treatment of acne vulgaris", J Drugs Dermatol, 7, pp.139~145 (2008)
- Wanitphakdeedecha R, "Photopneumatic therapy for the treatment of acne", J Drugs Dermatol, 8, pp.239~241 (2009)
- Munavalli GS, "Combination light therapies for the treatment of acne: An overview and introduction to photopneumatic therapy", Med Laser Appl (2008)
- Sakamoto FH, "Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Acne vulgaris: when and why consider photodynamic therapy?", J Am Acad Dermatol, 63, pp.183~193 (2010)
- Omi T, "Ultrastructural evidence for thermal injury to pilosebaceous units during the treatment of acne using photopneumatic (PPX) therapy", J Cosmet Laser Ther, 10, pp.7~11 (2008)
- Gold MH, "Efficacy of a novel combination of pneumatic energy and broadband light for the treatment of acne", J Drugs Dermatol, 7, pp.639~642 (2008)