비중격 성형술에서 Morniflumate, Paracetamol, Pregabalin의 통증 조절 효과 비교
Comparison of the Analgesic Effects of Morniflumate, Paracetamol, and Pregabalin in Septoplasty Patients
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Objectives：Septoplasty is a common otolaryngological procedure. Patients who undergo septoplasty frequently complain of pain in the early postoperative period due to surgical trauma and nasal packing. The oral analgesics morniflumate (a nonsteroidal anti-inflammatory drug [NSAID]), paracetamol, and pregabalin are commonly used to control pain after septoplasty. We compared the efficacy of these analgesics in controlling postoperative pain. Materials and Methods：The study included 44 male patients who underwent septoplasty due to nasal septal deviation. The patients received morniflumate (350 mg twice daily, n=15), paracetamol (650 mg three times daily, n=14), or pregabalin (75 mg twice daily, n=15), and postoperative pain was assessed for 3 days after surgery. Results：The postoperative pain decreased significantly over the observation period despite the type of analgesic administered. Although morniflumate was the most effective, followed by paracetamol and pregabalin, the differences were not statistically significant. Conclusions：We found no significant differences in efficacy among the three analgesics most commonly prescribed for postoperative pain after septoplasty.
Abstract
Background and Objectives：Septoplasty is a common otolaryngological procedure. Patients who undergo septoplasty frequently complain of pain in the early postoperative period due to surgical trauma and nasal packing. The oral analgesics morniflumate (a nonsteroidal anti-inflammatory drug [NSAID]), paracetamol, and pregabalin are commonly used to control pain after septoplasty. We compared the efficacy of these analgesics in controlling postoperative pain. Materials and Methods：The study included 44 male patients who underwent septoplasty due to nasal septal deviation. The patients received morniflumate (350 mg twice daily, n=15), paracetamol (650 mg three times daily, n=14), or pregabalin (75 mg twice daily, n=15), and postoperative pain was assessed for 3 days after surgery. Results：The postoperative pain decreased significantly over the observation period despite the type of analgesic administered. Although morniflumate was the most effective, followed by paracetamol and pregabalin, the differences were not statistically significant. Conclusions：We found no significant differences in efficacy among the three analgesics most commonly prescribed for postoperative pain after septoplasty.
참고문헌 (19)
- Sommer M, "Prevalence and predictors of postoperative pain after ear, nose, and throat surgery", Arch Otolaryngol Head Neck Surg, 35(2), pp.124~130 (2009)
- Sener M, "Patient-controlled analgesia with lornoxicam vs. dipyrone for acute postoperative pain relief after septorhinoplasty:a prospective, randomized, double-blind, placebocontrolled study", Eur J Anaesthesiol, 25(3), pp.177~182 (2008)
- Kehlet H, "Anaesthesia, surgery, and challenges in postoperative recovery", Lancet, 362(9399), pp.1921~1928 (2003)
- Koputan MH, "The effects of tramadol and levobupivacaine Infiltration on postoperative analgesia in functional endoscopic sinus surgery and septorhinoplasty", Balkan Med J, 29(4), pp.391~394 (2012)
- 김준호, "The Efficacy of Preemptive Analgesia With Pregabalin in Septoplasty", Clinical and Experimental Otorhinolaryngology, 7(2), pp.102~105 (2014), 대한이비인후과학회[DOI]
- Gupta A, "NSAIDs in the treatment of postoperative pain", Curr Pain Headache Rep, 20(11), pp.62~ (2016)
- Kaye AD, "An update on nonopioids: intravenous or oral analgesics for perioperative pain management", Anesthesiology Ciln, 35(2), pp.e55~e71 (2017)
- Kim SY, "Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial", Surg Endosc, 24(11), pp.2776~2781 (2010)
- Kim SY, "Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study", Acta Anaesthesiol Scand, 55(3), pp.290~296 (2011)
- Reuben SS, "The analgesic efficacy of celecoxib, pregabalin, and their combination for spinal fusion surgery", Anesth Analg, 103(5), pp.1271~1277 (2006)
- Sener M, "Efficacy of lornoxicam for acute postoperative pain relief after septoplasty: a comparison with diclofenac, ketoprofen, and dipyrone", J Clin Anesth, 20(2), pp.103~108 (2008)
- Toms L, "Single dose oral paracetamol (acetaminophen) for postoperative pain in adults", Cochrane Database Syst Rev, 8(4), pp.CD004602~ (2008)
- 문지승, "성인 편도수술 환자에서 정맥 내 자가 통증 조절법의 유용성", 임상이비인후과, 26(2), pp.225~229 (2015), 대한이비인후과학회 부산,울산,경남 지부회[DOI]
- Caliskan E, "Comparison of the effects of intravenous Dexketoprofen Trometamol versus Paracetamol on postoperative analgesia in patients undergoing Septoplasty: A randomised double-blind clinical trial", Pak J Med Sci, 34(3), pp.546~552 (2018)
- Gajraj NM., "Pregabalin: its pharmacology and use in pain management", 105(6), pp.1805~1815 (2007)
- Demirhan A, "Effect of pregabalin and dexamethasone on postoperative analgesia after septoplasty", Pain Res Treat, 2014, pp.850794~ (2014)
- Szychta P, "Assessment of early post-operative pain following septorhinoplasty", J Laryngol Otol, 124(11), pp.1194~1199 (2010)
- Bingöl F, "Comparison of Early-period results of nasal splint and merocel nasal packs in septoplasty", Turk Arch Otorhinolaryngol, 55(3), pp.136~139 (2017)
- Harirforoosh S, "Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications", J Pharm Pharm Sci, 16(5), pp.821~847 (2013)