녹내장 시야 지표의 임상적 유용성
Clinical Validation of Visual Field Index
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초록
목적: 험프리 자동시야검사계의 visual field index(VFI)와 MD, PSD, AGIS 점수 그리고 빛간섭단층촬영상의 망막신경섬유층의 평균두께와의 상관관계 및 각 지표들의 녹내장 진단능력을 고찰하였다. 대상과 방법: 녹내장 115안, 정상안 78안에서 시야검사와 빛간섭단층촬영을 시행하고, 각 지표들과 VFI와의 상관관계와 녹내장 진단력을 Pearson correlation 분석 및 Receiver operating characteristic (ROC) 곡선으로 분석하였다. 결과: VFI와 각 지표들과의 상관관계는 통계적으로 유의하였으며(모두, p<0.001), VFI의 AUROC값은 PSD, 빛간섭단층촬영상의 평균두께와는 유의한 차이가 없었으나(p=0.756, p=0.638), MD와 AGIS점수보다는 유의하게 높은 진단력을 보여주었다(모두, p<0.001). 결론: VFI는 AGIS 점수 및 MD, PSD 그리고 빛간섭단층촬영상의 망막신경섬유층 두께와 강한 상관관계를 보였으며, 우수한 녹내장진단능력으로 그 임상적 유용성을 확인할 수 있었다
Abstract
Purpose: To determine the associations of visual field index (VFI) with advanced glaucoma intervention study (AGIS) score, mean deviation (MD), pattern standard deviation (PSD), and average retinal nerve fiber layer (RNFL) thickness as measured by optical coherence tomography (OCT) and to evaluate the diagnostic abilities of these parameters. Methods: One hundred fifteen glaucomatous eyes and 78 healthy eyes were enrolled in this cross-sectional study. Each participant had a Humphrey visual field analyzer test and OCT done. The diagnostic abilities of these parameters were analyzed using the receiver operating characteristic (ROC) curve, and we sought to determine the association of these parameters with VFI by Pearson correlation analysis. Results: The associations between analyzed parameters and VFI were statistically significant (all, p<0.001). The area under the ROC curve (AUROC) value of VFI was greater than that of the MD and AGIS score (all, p<0.001) but was not different from the PSD and RNFL average thickness measured by OCT (p=0.756, p=0.638). Conclusions: The VFI showed significant associations with AGIS score, MD, PSD, and average RNFL thickness as measured by OCT and revealed similar diagnostic abilities as these parameters.
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