Role of histone modification in chromatin-mediated transcriptional repression in protozoan parasite Trichomonas vaginalis
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Trichomonas vaginalis is an extracellular flagellated protozoanresponsible for trichomoniasis, one of the most prevalentnonviral sexually transmitted infections. To persist in its host,T. vaginalis employs sophisticated gene regulation mechanismsto adapt to hostile environmental conditions. Althoughtranscriptional regulation is crucial for this adaptation, theunderlying molecular mechanisms remain poorly understood. Epigenetic regulation, particularly histone modifications, hasemerged as a key modulator of gene expression. A previousstudy demonstrated that histone modifications, H3K4me3 andH3K27ac, promote active transcription. However, the completeextent of epigenetic regulation in T. vaginalis remainsunclear. The present study extended these findings by exploringthe repressive role of two additional histone H3modifications, H3K9me3 and H3K27me3. Genome-wide analysisrevealed that these modifications negatively correlated withgene expression, affecting protein-coding and transposable elementgenes (TEGs). These findings offer new insights into the dualrole of histone modifications in activating and repressing geneexpression and provide a more comprehensive understandingof epigenetic regulation in T. vaginalis. This expanded knowledgemay inform the development of novel therapeuticstrategies targeting the epigenetic machinery of T. vaginalis.
Abstract
Trichomonas vaginalis is an extracellular flagellated protozoanresponsible for trichomoniasis, one of the most prevalentnonviral sexually transmitted infections. To persist in its host,T. vaginalis employs sophisticated gene regulation mechanismsto adapt to hostile environmental conditions. Althoughtranscriptional regulation is crucial for this adaptation, theunderlying molecular mechanisms remain poorly understood. Epigenetic regulation, particularly histone modifications, hasemerged as a key modulator of gene expression. A previousstudy demonstrated that histone modifications, H3K4me3 andH3K27ac, promote active transcription. However, the completeextent of epigenetic regulation in T. vaginalis remainsunclear. The present study extended these findings by exploringthe repressive role of two additional histone H3modifications, H3K9me3 and H3K27me3. Genome-wide analysisrevealed that these modifications negatively correlated withgene expression, affecting protein-coding and transposable elementgenes (TEGs). These findings offer new insights into the dualrole of histone modifications in activating and repressing geneexpression and provide a more comprehensive understandingof epigenetic regulation in T. vaginalis. This expanded knowledgemay inform the development of novel therapeuticstrategies targeting the epigenetic machinery of T. vaginalis.