소아 신장이식 환자에서 발생한 파르보바이러스 B19에 의한 심한 빈혈에 대한 증례 보고 및 문헌 고찰
Severe Anemia Caused by Parvovirus B19 Infection in Two Pediatric Kidney Transplantation Recipients
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초록
신장이식 환자에서 만성 빈혈은 치료 과정 중 발생하는 합병증으로 바이러스 감염, 적혈구형성호르몬결핍, 출혈, 면역억제제의 부작용 등과 관련이 있다. 신장이식 환자에서 파르보바이러스 B19에 의한 빈혈은 초감염 혹은 기존 감염의 재활성화로 발생할 수 있으며, 아직 이에 대한 치료법은 정립이 되어 있지 않다. 특히, 소아청소년 신장이식 환자에 대한 보고나 자료는 더욱 드물다. 저자들은 소아청소년 신장이식 환자에서 발생한 심각한 빈혈을 파르보바이러스 B19 PCR 검사법으로 진단하고, 정맥내글로불린으로 재발 없이 성공적으로 치료한 두 증례와 문헌 고찰을 보고하는 바이다.
Abstract
Anemia commonly occurs in kidney transplantation (KT) recipients. Many factors such as viral infection, bleeding, erythropoietin deficiency, and immunosuppressants are the causes of chronic anemia in KT recipients. We report 2 cases who developed severe anemia caused by parvovirus B19 infection and were successfully treated with intravenous immunoglobulin in pediatric KT recipients.
참고문헌 (16)
- Eid AJ, "Human parvovirus B19 in solid organ transplantation: guidelines from the American society of transplantation infectious diseases community of practice", Clin Transplant, 33, pp.e13535~ (2019)
- Kimberlin DW, "Red book: 2021–2024 report of the Committee on Infectious Diseases", pp.562~566 (2021), American Academy of Pediatrics
- 구소은, "소아에서 신장 이식 후 발생한 Parvovirus B19 감염 2례", Childhood Kidney Diseases, 9(2), pp.275~281 (2005), 대한소아신장학회
- Eid AJ, "Parvovirus B19 infection after transplantation: a review of 98 cases", Clin Infect Dis, 43, pp.40~48 (2006)
- Winkelmayer WC, "Pottransplantation anemia: management and rationale", Clin J Am Soc Nephrol, 3(Suppl 2), pp.S49~S55 (2008)
- Barsoum NR, "Treatment of parvovirus B-19 (PV B-19) infection allows for successful kidney transplantation without disease recurrence", Am J Transplant, 2, pp.425~428 (2002)
- Waldman M, "Parvovirus-B19-associated complications in renal transplant recipients", Nat Clin Pract Nephrol, 3, pp.540~550 (2007)
- Winkelmayer WC, "Pharmacoepidemiology of anemia in kidney transplant recipients", J Am Soc Nephrol, 15, pp.1347~1352 (2004)
- Barzon L, "Detection of viral DNA in kidney graft preservation and washing solutions is predictive of posttransplant infections in pediatric recipients", J Infect Dis, 200, pp.1425~1433 (2009)
- Mathias RS, "Chronic anemia as a complication of parvovirus B19 infection in a pediatric kidney transplant patient", Pediatr Nephrol, 11, pp.355~357 (1997)
- Subtirelu MM, "Acute renal failure in a pediatric kidney allograft recipient treated with intravenous immunoglobulin for parvovirus B19 induced pure red cell aplasia", Pediatr Transplant, 9, pp.801~804 (2005)
- Pinto V, "Severe anemia from parvovirus b19 infection in pediatric renal transplant recipients: two case reports", Transplant Proc, 40, pp.3261~3264 (2008)
- Shen Q, "Long-term remission of recurrent severe anemia as a result of parvovirus B19 infection in a pediatric renal transplant recipient", Pediatr Transplant, 15, pp.E76~E79 (2011)
- Malbora B, "Pure red cell aplasia due to parvovirus B19: erythropoietin-resistant anemia in a pediatric kidney recipient", Exp Clin Transplant, 15, pp.369~371 (2017)
- Renoult E, "Recurrent anemia in kidney transplant recipients with parvovirus B19 infection", Transplant Proc, 38, pp.2321~2323 (2006)
- Crabol Y, "Intravenous immunoglobulin therapy for pure red cell aplasia related to human parvovirus b19 infection: a retrospective study of 10 patients and review of the literature", Clin Infect Dis, 56, pp.968~977 (2013)
