혈관인지장애로 내원한 골수세포과산화효소-항중성구세포질항체 연관다발혈관염 환자
Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-associated Vasculitis Presenting with Vascular Cognitive Impairment
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초록
A 67-year-old woman with myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis presented with progressive cognitive decline and was diagnosed with amnestic mild cognitive impairment. Brain magnetic resonance imaging (MRI) revealed chronic infarcts consistent with cerebral small vessel disease. Although conventional vascular risk factors were present, they were insufficient to fully account for the imaging and clinical findings. This case suggests that MPO-ANCA-associated vasculitis should be considered in the differential diagnosis of patients presenting with vascular cognitive impairment, particularly in the presence of systemic inflammatory features.
Abstract
A 67-year-old woman with myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis presented with progressive cognitive decline and was diagnosed with amnestic mild cognitive impairment. Brain magnetic resonance imaging (MRI) revealed chronic infarcts consistent with cerebral small vessel disease. Although conventional vascular risk factors were present, they were insufficient to fully account for the imaging and clinical findings. This case suggests that MPO-ANCA-associated vasculitis should be considered in the differential diagnosis of patients presenting with vascular cognitive impairment, particularly in the presence of systemic inflammatory features.