Intraosseous hibernoma of the mandible: A case report
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Hibernoma is a benign tumor of brown adipose tissue, and intraosseous involvement is exceedingly uncommon. We report a 52-year-old man with a mandibular lesion incidentally detected on panoramic imaging. Panoramic radiograph showed a well-circumscribed radiolucency; cone-beam CT demonstrated internal calcified foci, cor-tical thinning, and adjacent sclerosis. The working differential favored non-ossifying fibroma and, less likely, a simple bone cyst. The lesion was treated by surgical enucleation with the extraction of the impacted third molar. Histopathology revealed large polygonal brown adipocytes with eosinophilic, multivacuolated cytoplasm, estab-lishing intraosseous hibernoma. At seven-month follow-up, radiographs showed internal osseous regeneration without recurrence. Initial differential diagnosis favored common mandibular lesions. The diagnosis of intraos-seous hibernoma was subsequently established by histopathology, underscoring the importance of radiologic–pathologic correlation in radiolucent jaw lesions with adjacent sclerotic features. (J Korean Dent Assoc 2025; 63(10): 335-339)
Abstract
Hibernoma is a benign tumor of brown adipose tissue, and intraosseous involvement is exceedingly uncommon. We report a 52-year-old man with a mandibular lesion incidentally detected on panoramic imaging. Panoramic radiograph showed a well-circumscribed radiolucency; cone-beam CT demonstrated internal calcified foci, cor-tical thinning, and adjacent sclerosis. The working differential favored non-ossifying fibroma and, less likely, a simple bone cyst. The lesion was treated by surgical enucleation with the extraction of the impacted third molar. Histopathology revealed large polygonal brown adipocytes with eosinophilic, multivacuolated cytoplasm, estab-lishing intraosseous hibernoma. At seven-month follow-up, radiographs showed internal osseous regeneration without recurrence. Initial differential diagnosis favored common mandibular lesions. The diagnosis of intraos-seous hibernoma was subsequently established by histopathology, underscoring the importance of radiologic–pathologic correlation in radiolucent jaw lesions with adjacent sclerotic features. (J Korean Dent Assoc 2025; 63(10): 335-339)