본문 바로가기
KERD
논문KCI 등재

뇌졸중 환자의 당뇨병 약물 요법

Pharmacotherapy of Diabetes Focused on Stroke

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류신경과학

초록

Cardiovascular disease, including stroke, is one of the major causes of death in diabetes. Numerous studies have long suggested reducing macrovascular complication such as ischemic vascular disease through intensive glycemic control, but none was successful proving the effect of glycemic control. Recently, new possibilities in cardiovascular disease reduction have been proposed through cardiovascular safety trials of newly developed anti-hyperglycemic agents. The purpose of this review is to introduce the traditional and newly developed anti-diabetic medications and review their effects regarding cardiovascular outcomes mainly focusing on stroke.

Abstract

Cardiovascular disease, including stroke, is one of the major causes of death in diabetes. Numerous studies have long suggested reducing macrovascular complication such as ischemic vascular disease through intensive glycemic control, but none was successful proving the effect of glycemic control. Recently, new possibilities in cardiovascular disease reduction have been proposed through cardiovascular safety trials of newly developed anti-hyperglycemic agents. The purpose of this review is to introduce the traditional and newly developed anti-diabetic medications and review their effects regarding cardiovascular outcomes mainly focusing on stroke.

참고문헌 (45)

  1. "Stroke fact sheet in Korea 2018" (2018)[URL]
  2. "Diabetes fact sheet in Korea 2018" (2018)[URL]
  3. Azimova K, "Cardiovascular safety profile of currently available diabetic drugs", Ochsner J, 14, pp.616~632 (2014)
  4. Emerging Risk Factors Collaboration, "Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease : a collaborative meta-analysis of 102 prospective studies", Lancet, 375, pp.2215~2222 (2010)
  5. Kernan WN, "Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack : a guideline for healthcare professionals from the American Heart Association", American Stroke Association, 2014, pp.45, 2160~2236
  6. UK Prospective Diabetes Study (UKPDS) Group, "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)", Lancet, 352, pp.837~853 (1998)
  7. Diabetes Control and Complications Trial Research Group, "The effect of intensive treatment of diabetes on the development and progression of long-term complications insulin-dependent diabetes mellitus", N Engl J Med, 329, pp.977~986 (1993)
  8. Action to Control Cardiovascular Risk in Diabetes Study Group, "Effects of intensive glucose lowering in type 2 diabetes", N Engl J Med, 358, pp.2545~2559 (2008)
  9. ADVANCE Collaborative Group, "Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes", N Engl J Med, 358, pp.2560~2572 (2008)
  10. Duckworth W, "Glucose control and vascular complications in veterans with type 2 diabetes", N Engl J Med, 360, pp.129~139 (2009)
  11. Holman RR, "10-year follow-up of intensive glucose control in type 2 diabetes", N Engl J Med, 359, pp.1577~1589 (2008)
  12. Bailey CJ, "Metformin", N Engl J Med, 334, pp.574~579 (1996)
  13. "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group", Lancet, 352, pp.854~865 (1998)
  14. Li J, "Effects of metformin in experimental stroke", Stroke, 41, pp.2645~2652 (2010)
  15. Davies MJ, "Management of hyperglycemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)", Diabetes Care, 41, pp.2669~2701 (2018)
  16. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee, "Pharmacologic management of type 2 diabetes", Can J Diabetes, 37, pp.S61~S68 (2013)
  17. Aguilar-Bryan L, "Cloning the beta cell high-affinity sulfonylurea receptor : a regulator of insulin secretion", Science, 268, pp.423~426 (1995)
  18. Quast U, "The impact of ATP-sensitive K+channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium", Diabetes, 53, pp.156~164 (2004)
  19. Stephan D, "Selectivity of repaglinide and glibenclamide for the pancreatic over the cardiovascular K(ATP)channels", Diabetologia, 49, pp.2039~2048 (2006)
  20. Sun HS, "Neuronal K(ATP)channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic-ischemic brain injury", Exp Neurol, 263, pp.161~171 (2015)
  21. Kunte H, "Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke", Stroke, 38, pp.2526~2530 (2007)
  22. Weih M, "Sulfonylurea drugs do not influence initial stroke severity and in-hospital outcome in stroke patients with diabetes", Stroke, 32, pp.2029~2032 (2001)
  23. Bannister CA, "Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls", Diabetes Obes Metab, 16, pp.1165~1173 (2014)
  24. Liu R, "Cerebrovascular safety of sulfonylureas : the role of K ATP channels in neuroprotection and the risk of stroke in patients with type 2 diabetes", Diabetes, 65, pp.2795~2809 (2016)
  25. Yki-Jarvinen H, "Thiazolidinediones", N Engl J Med, 351, pp.1106~1118 (2004)
  26. Kahn SE, "Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy", N Engl J Med, 355, pp.2427~2443 (2006)
  27. Dormandy JA, "Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study(PROspective pioglitAzone Clinical Trial In macroVascular Events) : a randomised controlled trial", Lancet, 366, pp.1279~1289 (2005)
  28. Wilcox R, "Effects of pioglitazone in patients with type 2 diabetes with or without previous stroke : results from PROactive(PROspective pioglitAzone Clinical Trial In macroVascular Events 04)", Stroke, 38, pp.865~873 (2007)
  29. Kernan WN, "Pioglitazone after ischemic stroke or transient ischemic attack", N Engl J Med, 374, pp.1321~1331 (2016)
  30. Kernan WN, "Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke", Neurology, 60, pp.1447~1451 (2003)
  31. Kernan WN, "Insulin resistance and risk for stroke", Neurology, 59, pp.809~815 (2002)
  32. Lewis JD, "Risk of bladder cancer among diabetic patients treated with pioglitazone : interim report of a longitudinal cohort study", Diabetes Care, 34, pp.916~922 (2011)
  33. Nauck MA, "The incretin effect in healthy individuals and those with type 2 diabetes : physiology, pathophysiology, and response to therapeutic interventions", Lancet Diabetes Endocrinol, 4, pp.525~536 (2016)
  34. Scirica BM, "Saxagliptin and cardiovascular outcomes in patients with type 2diabetes mellitus", N Engl J Med, 369, pp.1317~1326 (2013)
  35. Zannad F, "Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE : a multicentre, randomised, double-blind trial", Lancet, 385, pp.2067~2076 (2015)
  36. Green JB, "Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes", N Engl J Med, 373, pp.232~242 (2015)
  37. Rosenstock J, "Effect of linagliptin vs placebo on major cardiovascular events in adults with type 2 diabetes and high cardiovascular and renal risk : the CARMELINA randomized clinical trial", JAMA, 321, pp.69~79 (2019)
  38. Zinman B, "Empagliflozin, cardiovascular outcomes, and mortality in type 2diabetes", N Engl J Med, 373, pp.2117~2128 (2015)
  39. Neal B, "Canagliflozin and cardiovascular and renal events in type 2diabetes", N Engl J Med, 377, pp.644~657 (2017)
  40. Wiviott SD, "Dapagliflozin and cardiovascular outcomes in type 2 diabetes", N Engl J Med, 380, pp.347~357 (2019)
  41. Wu JH, "Effects of sodium-glucose cotransporter-2 inhibitors on cardiovascular events, death, and major safety outcomes in adults with type 2 diabetes : a systematic review and meta-analysis", Lancet Diabetes Endocrinol, 4, pp.411~419 (2016)
  42. Marso SP, "Liraglutide and cardiovascular outcomes in type 2diabetes", N Engl J Med, 375, pp.311~322 (2016)
  43. Marso SP, "Semaglutide and cardiovascular outcomes in patients with type 2diabetes", N Engl J Med, 375, pp.1834~1844 (2016)
  44. ORIGIN Trial Investigators, "Basal insulin and cardiovascular and other outcomes in dysglycemia", N Engl J Med, 367, pp.319~328 (2012)
  45. 고승현, "Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association", Diabetes and Metabolism Journal, 41(5), pp.337~348 (2017), 대한당뇨병학회[DOI]

관련 논문AI추천

Effects of Thiazolidinedione and New Antidiabetic Agents on StrokeChang Ho Ahn, Soo Lim대한뇌졸중학회 · 대한뇌졸중영문학회지2019 · 제21권 제2호Diabetes and Stroke: What Are the Connections?Alejandro A Rabinstein, Alice Y.Y. Cheng, Ofri Mosenzon, Simona Sacco대한뇌졸중학회 · 대한뇌졸중영문학회지2023 · 제25권 제1호Aggressive Glucose Control for Acute Ischemic Stroke Patients by Insulin Infusion구자성, 권오현, 김나영, 김병건, 박종무, 이정주, 이지성, 장윤숙대한신경과학회 · Journal of Clinical Neurology2009 · 제5권 제4호허혈성 뇌졸중의 이차예방을 위한 항혈전제 치료강태호, 조한진대한뇌신경재활학회 · 뇌신경재활2014 · 제7권 제2호Stroke Update 2009: 뇌졸중의 위험인자 및 일차 예방박종무대한뇌졸중학회 · 대한뇌졸중영문학회지2009 · 제11권 제2호당뇨병과 뇌졸중 병력을 모두 가진 급성 뇌경색 환자에서 증상 발생 3-4.5시간대 정맥내혈전용해술의 안전성 및 효과이준, 강규식, 권지현, 김대현, 김동억, 김보영, 김욱주, 김재국, 김준태, 박광열, 박상순, 박정주, 박종무, 박태환, 박형종, 박홍균, 배희준, 손성일, 신동익, 오기창, 용영복, 이경복, 이민우, 이병철, 이상화, 이수주, 이지성, 장성화, 조용진, 차재관, 최강호, 최재철, 홍근식, 홍정호대한신경과학회 · 대한신경과학회지2023 · 제41권 제2호

이 간행물의 다른 논문 (18건)