Dissimilar Effects of Tolterodine on Detrusor Overactivity in Awake Rats with Chemical Cystitis and Partial Bladder Outlet Obstruction
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Purpose: We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the NVCs in these models. Methods: A total of 20 female Sprague-Dawley rats were used in this study. In eight rats, chemical cystitis was induced by intravesical instillation of HCl. Twelve rats were subjected to sham instillations or partial BOO. Four weeks after intravesical instillation or 2 weeks after partial BOO, cystometrograms were obtained by use of simultaneous recording of intravesical and intraabdominal pressure in all unanesthetized, unrestrained rats in metabolic cages. Results: A total of 17 rats survived. In the rats with acute injury by HCl, 50% showed detrusor overactivity (DO), which was not seen in the sham group. The cystitis group had lower DO pressure without a difference in DO frequency compared with the BOO group. After the administration of tolterodine, the cystitis group showed no difference in DO frequency or pressure, whereas the BOO group showed decreased values for both parameters. Conclusions: Our study showed that toleterodine produced no effect on DO during the filling phase in rats with chronic chemical cystitisbut decreased the frequency and pressure of DO in rats with BOO. Clinically, studies are needed to improve the treatment effect of anticholinergic drugs ininterstitial cystitis patients with overactive bladder.
Abstract
Purpose: We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the NVCs in these models. Methods: A total of 20 female Sprague-Dawley rats were used in this study. In eight rats, chemical cystitis was induced by intravesical instillation of HCl. Twelve rats were subjected to sham instillations or partial BOO. Four weeks after intravesical instillation or 2 weeks after partial BOO, cystometrograms were obtained by use of simultaneous recording of intravesical and intraabdominal pressure in all unanesthetized, unrestrained rats in metabolic cages. Results: A total of 17 rats survived. In the rats with acute injury by HCl, 50% showed detrusor overactivity (DO), which was not seen in the sham group. The cystitis group had lower DO pressure without a difference in DO frequency compared with the BOO group. After the administration of tolterodine, the cystitis group showed no difference in DO frequency or pressure, whereas the BOO group showed decreased values for both parameters. Conclusions: Our study showed that toleterodine produced no effect on DO during the filling phase in rats with chronic chemical cystitisbut decreased the frequency and pressure of DO in rats with BOO. Clinically, studies are needed to improve the treatment effect of anticholinergic drugs ininterstitial cystitis patients with overactive bladder.
참고문헌 (26)
- Gillenwater JY, "Summary of the National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases Workshop on Interstitial Cystitis, National Institutes of Health, Bethesda, Maryland, August 28-29, 1987", J Urol, 140, pp.203~206 (1988)
- Ibrahim IA, "Prevalence of self-reported interstitial cystitis (IC) and interstitial-cystitis-like symptoms among adult women in the community", Int Urol Nephrol, 39, pp.489~495 (2007)
- Sant GR, "Etiology, pathogenesis, and diagnosis of interstitial cystitis", Rev Urol, 4(Suppl 1), pp.S9~S15 (2002)
- Barry MJ, "Boston Area Community Health (BACH) Investigators. Overlap of different urological symptom complexes in a racially and ethnically diverse, community-based population of men and women", BJU Int, 101, pp.45~51 (2008)
- Minaglia S, "Increased prevalence of interstitial cystitis in women with detrusor overactivity refractory to anticholinergic therapy", Urology, 66, pp.702~706 (2005)
- Alhasso AA, "Anticholinergic drugs versus non-drug active therapies for overactive bladder syndrome in adults", Cochrane Database Syst Rev, (4), pp.CD003193~ (2006)
- Abrams P, "Describing bladder storage function: overactive bladder syndrome and detrusor overactivity", Urology, 62(5 Suppl 2), pp.28~37 (2003)
- Abrams P, "The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society", Neurourol Urodyn, 21, pp.167~178 (2002)
- Rivas DA, "Molecular marker for development of interstitial cystitis in rat model: isoactin gene expression", J Urol, 157, pp.1937~1940 (1997)
- 이택, "Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats-effects of bladder outlet obstruction and intravesical PGE(2)", NEUROUROLOGY AND URODYNAMICS, 27, pp.88~95, WILEY-LISS
- Kirkemo A, "Associations among urodynamic findings and symptoms in women enrolled in the Interstitial Cystitis Data Base (ICDB) Study", Urology, 49(5A Suppl), pp.76~80 (1997)
- Hanno PM, "Interstitial cystitis-epidemiology, diagnostic criteria, clinical markers", Rev Urol, 4(Suppl 1), pp.S3~S8 (2002)
- Metts JF, "Interstitial cystitis: urgency and frequency syndrome", Am Fam Physician, 64, pp.1199~1206 (2001)
- El Khoudary SR, "Severity of interstitial cystitis symptoms and quality of life in female patients", J Womens Health (Larchmt), 18, pp.1361~1368 (2009)
- Michael YL, "Quality of life among women with interstitial cystitis", J Urol, 164, pp.423~427 (2000)
- Desireddi NV, "Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha as possible biomarkers for the chronic pelvic pain syndrome", J Urol, 179, pp.1857~1861 (2008)
- Sant GR, "The role of the mast cell in interstitial cystitis", Urol Clin North Am, 21, pp.41~53 (1994)
- Yoshimura N, "Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation", J Neurosci, 19, pp.4644~4653 (1999)
- Coderre TJ, "Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence", Pain, 52, pp.259~285 (1993)
- Dupont MC, "Histological and neurotrophic changes triggered by varying models of bladder inflammation", J Urol, 166, pp.1111~1118 (2001)
- 진롱후, "Urodynamic Findings in an Awake Chemical Cystitis Rat Model Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures", International Neurourology Journal, 14(1), pp.54~60 (2010), 대한배뇨장애요실금학회
- Gosling JA, "Decrease in the autonomic innervation of human detrusor muscle in outflow obstruction", J Urol, 136, pp.501~504 (1986)
- Speakman MJ, "Bladder outflow obstruction--a cause of denervation supersensitivity", J Urol, 138, pp.1461~1466 (1987)
- Yokoyama O, "The response of the detrusor muscle to acetylcholine in patients with infravesical obstruction", Urol Res, 19, pp.117~121 (1991)
- Chapple C, "Antimuscarinics in men with lower urinary tract symptoms suggestive of bladder outlet obstruction due to benign prostatic hyperplasia", Curr Opin Urol, 20, pp.43~48 (2010)
- Andersson KE, "Antimuscarinics and the overactive detrusor--which is the main mechanism of action", Eur Urol, 43, pp.1~5 (2003)