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MeO-PEG-OMe를 사용한 benzo-[1,4]-oxazinone 화합물의마이크로웨이브 합성

Microwave-assisted Synthesis of Benzo-[1,4]-oxazinones Using MeO-PEG-OMe as Solvent

신동수|김신형|장기완|임재민|감경희
대한화학회|2012.08|대한화학회지 (Journal of the Korean Chemical Society)|제56권 제4호|pp. 468-472|DOI http://dx.doi.org/10.5012/jkcs.2012.56.4.468

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참고문헌

키워드

Microwave-assistedBenzo-[14]-oxazinoneMeO-PEG-OMePyrido-[1Smiles 자리옮김반응Smiles rearrangement
주제분류화학

초록

마이크로웨이브를 이용한 가열 방법과 MeO-PEG-OMe를 용매로 사용하여, benzo-[1,4]-oxazinone의 효율적인 one-pot 합성방법을 개발하였으며, 개발한 합성방법을 이용하여, 8 가지의 benzo-[1,4]-oxazinone 화합물과 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one을 좋은 수율로 합성하였다.

Abstract

Efficient one-pot microwave-assisted synthesis of various benzo-[1,4]-oxazinones via Smiles rearrangement is described. Treatment of 2-chloroacetamide, substituted 2-chlorophenols and cesium carbonate in MeO-PEG-OMe (2,000) as solvent afforded the corresponding benzo-[1,4]-oxazinones and 1H-pyrido[2,3-b][1,4]-oxazin-2-(3H)-one as moderate yield.

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