방사성요오드 불응성 갑상선암에서 티로신키나아제 억제제 투여로 유발된 중증 피로감의 관리
Management of Severe Fatigue Induced by Tyrosine Kinase Inhibitor in Radioiodine Refractory Thyroid Cancer
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Tyrosine kinase inhibitor is known to prolong progression free survival in radioiodine refractory thyroid cancer patients. Fatigue/asthenia/malaise is one of most common adverse events by the tyrosine kinase inhibitor treatment, and management of the adverse event is important to keep the drug medication longer which is essential for the survival benefit. In the case report, a radioiodine refractory thyroid cancer patient receiving tyrosine kinase inhibitor experienced severe fatigue, and a pathologic fracture of right humerus occurred by slipping down which was tightly linked with the adverse event of the drug. The pathologic fracture was surgically well managed and the adverse event was well controlled by supportive managements combined with dose reduction of the tyrosine kinase inhibitor. The drug administration to the patient was kept more than 1 year without progression of the disease.
Abstract
Tyrosine kinase inhibitor is known to prolong progression free survival in radioiodine refractory thyroid cancer patients. Fatigue/asthenia/malaise is one of most common adverse events by the tyrosine kinase inhibitor treatment, and management of the adverse event is important to keep the drug medication longer which is essential for the survival benefit. In the case report, a radioiodine refractory thyroid cancer patient receiving tyrosine kinase inhibitor experienced severe fatigue, and a pathologic fracture of right humerus occurred by slipping down which was tightly linked with the adverse event of the drug. The pathologic fracture was surgically well managed and the adverse event was well controlled by supportive managements combined with dose reduction of the tyrosine kinase inhibitor. The drug administration to the patient was kept more than 1 year without progression of the disease.
참고문헌 (8)
- Brose MS, "Vemurafenib in patients with BRAF(V600E)-positive metastatic or unresectable papillary thyroid cancer refractory to radioactive iodine: a non-randomised, multicentre, open-label, phase 2 trial", Lancet Oncol, 17(9), pp.1272~1282 (2016)
- Schlumberger M, "Lenvatinib versus placebo in radioiodinerefractory thyroid cancer", N Engl J Med, 372(7), pp.621~630 (2015)
- Takahashi S, "Optimal use of lenvatinib in the treatment of advanced thyroid cancer", Cancers of the Head & Neck, 2, pp.7~ (2017)
- Brose MS, "Management of sorafenib-related adverse events: a clinician's perspective", Semin Oncol, 41(Suppl 2), pp.S1~S16 (2014)
- Worden F, "Safety and tolerability of sorafenib in patients with radioiodine-refractory thyroid cancer", Endocr Relat Cancer, 22(6), pp.877~887 (2015)
- Chrisoulidou A, "Treatment compliance and severe adverse events limit the use of tyrosine kinase inhibitors in refractory thyroid cancer", Onco Targets Ther, 8, pp.2435~2442 (2015)
- Resteghini C, "Management of tyrosine kinase inhibitors (TKI) side effects in differentiated and medullary thyroid cancer patients", Best Pract Res Clin Endocrinol Metab, 31(3), pp.349~361 (2017)
- Haddad RI, "Incidence and timing of common adverse events in Lenvatinib-treated patients from the SELECT trial and their association with survival outcomes", Endocrine, 56(1), pp.121~128 (2017)