Three Cases of Fever Unknown Origin with Lymphoproliferative Features and a Unique Pattern of 18-FDG Uptake on the Fusion PET/CT
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Evaluation of a fever of unknown origin (FUO) is complex. Recently, PET scanning has been approved for screening in FUO evaluation. We treated three cases of FUO associated with increased FDG uptake in the bone marrow of the femur and tibia on the fusion PET/CT; all three had the same pattern of uptake. Bone marrow biopsies revealed mature lymphocyte and histiocyte infiltration and myxoid changes in one case, and cortical bone involvement in another case. The cases were all young females who had fever with neutropenia and relative lymphocytosis that lasted for several weeks and then remitted spontaneously. Even though the results of the studies were not diagnostic, the unique uptake pattern on PET/CT and the histology might be related to the cause of the illness and should be studied further to assess the association with classic FUO.
Abstract
Evaluation of a fever of unknown origin (FUO) is complex. Recently, PET scanning has been approved for screening in FUO evaluation. We treated three cases of FUO associated with increased FDG uptake in the bone marrow of the femur and tibia on the fusion PET/CT; all three had the same pattern of uptake. Bone marrow biopsies revealed mature lymphocyte and histiocyte infiltration and myxoid changes in one case, and cortical bone involvement in another case. The cases were all young females who had fever with neutropenia and relative lymphocytosis that lasted for several weeks and then remitted spontaneously. Even though the results of the studies were not diagnostic, the unique uptake pattern on PET/CT and the histology might be related to the cause of the illness and should be studied further to assess the association with classic FUO.
참고문헌 (6)
- Gaeta GB, "Fever of unknown origin: a systematic review of the literature for 1995-2004", Nucl Med Commun, 27, pp.205~211 (2006)
- Carr R, "Detection of lymphoma in bone marrow by whole body positron emission tomography", Blood, 91, pp.3340~3346 (1998)
- Hans-Joachim W, "Diagnosis and treatment of posttransplantation lymphoproliferative disease after hematopoietic stem cell transplantation", Biol Blood Marrow Transplant, 8, pp.1~8 (2002)
- Ronald SG, "Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes", Blood, 98, pp.483~485 (2001)
- Riley UBG, "Detection of mycobacteria in bone marrow biopsy specimens taken to investigate pyrexia of unknown origin", JClin Pathol, 48, pp.706~709 (1995)
- Befaulkner-Jones, "Lymphoid aggregates in bone marrow: study of eventual outcome", J Clin Pathol, 41, pp.768~775 (1988)