Topographical Disorientation in Mild Cognitive Impairment: A Voxel-Based Morphometry Study
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Purpose: To assess the neural substrates underlying topographical disorientation (TD) in patients affected by mild cognitive impairment (MCI), forty-one patients diagnosed with MCI and 24 healthy control individuals were recruited. Methods: TD was assessed clinically in all participants. Neurological and neuropsychological evaluations and a volumetric-head magnetic resonance imaging scan were performed in each participant. Voxel-based morphometry was used to compare patterns of gray-matter atrophy between patients with and without TD, and a group of normal controls. Results: We found TD in 17 out of the 41 MCI patients (41.4%). The functional abilities were significantly impaired in MCI patients with TD compared to in MCI patients without TD. Voxel-based morphometry analyses showed that the presence of TD in MCI patients is associated with loss of gray matter in the medial temporal regions, including the hippocampus and parahippocampal cortex, the fusiform gyrus, the inferior occipital gyrus, the amygdala, and the cerebellum. Conclusions: The findings found in this study represent the first evidence that the presence of TD in patients with MCI is associated with loss of gray matter in those brain regions that have been documented to be responsible for orientation in both neuropsychological and neuroimaging studies.
Abstract
Background and Purpose: To assess the neural substrates underlying topographical disorientation (TD) in patients affected by mild cognitive impairment (MCI), forty-one patients diagnosed with MCI and 24 healthy control individuals were recruited. Methods: TD was assessed clinically in all participants. Neurological and neuropsychological evaluations and a volumetric-head magnetic resonance imaging scan were performed in each participant. Voxel-based morphometry was used to compare patterns of gray-matter atrophy between patients with and without TD, and a group of normal controls. Results: We found TD in 17 out of the 41 MCI patients (41.4%). The functional abilities were significantly impaired in MCI patients with TD compared to in MCI patients without TD. Voxel-based morphometry analyses showed that the presence of TD in MCI patients is associated with loss of gray matter in the medial temporal regions, including the hippocampus and parahippocampal cortex, the fusiform gyrus, the inferior occipital gyrus, the amygdala, and the cerebellum. Conclusions: The findings found in this study represent the first evidence that the presence of TD in patients with MCI is associated with loss of gray matter in those brain regions that have been documented to be responsible for orientation in both neuropsychological and neuroimaging studies.
참고문헌 (44)
- Renzi ED, "Disorders of space exploration and cognition" (1982), Wiley
- Aguirre GK, "Topographical disorientation:a synthesis and taxonomy", Brain, 122, pp.1613~1628 (1999)
- Habib M, "Pure topographical disorientation:a definition and anatomical basis", Cortex, 23, pp.73~85 (1987)
- Pallis CA, "Impaired identification of faces and places with agnosia for colours; report of a case due to cerebral embolism", J Neurol Neurosurg Psychiatry, 18, pp.218~224 (1955)
- Takahashi N, "Pure topographic disorientation due to right retrosplenial lesion", Neurology, 49, pp.464~469 (1997)
- Stark M, "Impairment of an Egocentric Map of Locations:Implications for Perception and Action", Cogn Neuropsychol, 13, pp.481~524 (1996)
- Barrash J, "A historical review of topographical disorientation and its neuroanatomical correlates", J Clin Exp Neuropsychol, 20, pp.807~827 (1998)
- Huang C, "Cingulate cortex hypoperfusion predicts Alzheimer’s disease in mild cognitive impairment", BMC Neurol, 2, pp.9~ (2002)
- Trivedi MA, "Structural MRI discriminates individuals with Mild Cognitive Impairment from age-matched controls:a combined neuropsychological and voxel based morphometry study", Alzheimers Dement, 2, pp.296~302 (2006)
- Seo SW, "Cortical thickness in single-versus multiple-domain amnestic mild cognitive impairment", Neuroimage, 36, pp.289~297 (2007)
- Desikan RS, "MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD", Neurology, 71, pp.819~825 (2008)
- Whitwell JL, "3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer’s disease", Brain, 130, pp.1777~1786 (2007)
- Hort J, "Spatial navigation deficit in amnestic mild cognitive impairment", Proc Natl Acad Sci U S A, 104, pp.4042~4047 (2007)
- Petersen RC, "Mild cognitive impairment as a diagnostic entity", J Intern Med, 256, pp.183~194 (2004)
- Kang Y, "Seoul Neuropsychological Screening Battery" (2003), Human Brain Research and Consulting
- Cummings JL, "The Neuropsychiatric Inventory:comprehensive assessment of psychopathology in dementia", Neurology, 44, pp.2308~2314 (1994)
- Morris JC, "The Clinical Dementia Rating(CDR):current version and scoring rules", Neurology, 43, pp.2412~2414 (1993)
- 구형모, "일상활동평가-복합(Seoul-Instrumental Activities of Daily Living ; S-IADL)의 신뢰도 및 타당도 연구", 신경정신의학, 43(2), pp.189~199 (2004), 대한신경정신의학회
- Pai MC, "Topographical disorientation in community-residing patients with Alzheimer’s disease", Int J Geriatr Psychiatry, 19, pp.250~255 (2004)
- Kim H, "Normative data on the Korean version of the Boston Naming Test", J Clin Exp Neuropsychol, 21, pp.127~133 (1999)
- Ashburner J, "Voxel-based morphometry--the methods", Neuroimage, 11, pp.805~821 (2000)
- Senjem ML, "Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease", Neuroimage, 26, pp.600~608 (2005)
- Bozzali M, "The contribution of voxel-based morphometry in staging patients with mild cognitive impairment", Neurology, 67, pp.453~460 (2006)
- Rondi-Reig L, "Is the cerebellum ready for navigation?", Prog Brain Res, 148, pp.199~212 (2005)
- Lee TM, "The cerebellum’s involvement in the judgment of spatial orientation:a functional magnetic resonance imaging study", Neuropsychologia, 43, pp.Liu HL~1877 (2005)
- Burguière E, "Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficit?", Nat Neurosci, 8, pp.1292~1294 (2005)
- Aguirre GK, "An area within human ventral cortex sensitive to"building"stimuli:evidence and implications", Neuron, 21, pp.373~383 (1998)
- Maguire EA, "Hippocampal involvement in human topographical memory:evidence from functional imaging", Philos Trans R Soc Lond B Biol Sci, 352, pp.1475~1480 (1997)
- Iaria G, "Retrosplenial and hippocampal brain regions in human navigation:complementary functional contributions to the formation and use of cognitive maps", Eur J Neurosci, 25, pp.890~899 (2007)
- Iaria G, "Navigational skills correlate with hippocampal fractional anisotropy in humans", Hippocampus, 18, pp.335~339 (2008)
- Epstein RA, "Where am I now? Distinct roles for parahippocampal and retrosplenial cortices in place recognition", J Neurosci, 27, pp.6141~6149 (2007)
- Ekstrom AD, "Cellular networks underlying human spatial navigation", Nature, 425, pp.184~188 (2003)
- Epstein R, "A cortical representation of the local visual environment", Nature, 392, pp.598~601 (1998)
- Grön G, "Brain activation during human navigation:gender-different neural networks as substrate of performance", Nat Neurosci, 3, pp.404~408 (2000)
- Zeki S, "Cerebral akinetopsia(visual motion blindness).A review", Brain, 114, pp.811~824 (1991)
- Jahn K, "Brain activation patterns during imagined stance and locomotion in functional magnetic resonance imaging", Neuroimage, 22, pp.1722~1731 (2004)
- Chételat G, "Mapping gray matter loss with voxel-based morphometry in mild cognitive impairment", Neuroreport, 13, pp.1939~1943 (2002)
- Karas GB, "Global and local gray matter loss in mild cognitive impairment and Alzheimer’s disease", Neuroimage, 23, pp.708~716 (2004)
- Pennanen C, "A voxel based morphometry study on mild cognitive impairment", J Neurol Neurosurg Psychiatry, 76, pp.11~14 (2005)
- Bell-McGinty S, "Differential cortical atrophy in subgroups of mild cognitive impairment", Arch Neurol, 62, pp.1393~1397 (2005)
- Fischer P, "Conversion from subtypes of mild cognitive impairment to Alzheimer dementia", Neurology, 68, pp.288~291 (2007)
- Money J, "Astandardized road-map test of direction sense. Baltimore" (1976), Johns Hopkins University Press
- Hunt LA, "Environmental cueing may effect performance on a road test for drivers with dementia of the Alzheimer type", Alzheimer Dis Assoc Disord, 11(Suppl,1), pp.13~16 (1997)
- Nadolne MJ, "Ecologic validity in neuropsychological assessment:prediction of wayfinding", J Int Neuropsychol Soc, 7, pp.675~682 (2001)