Unilateral Pigmented Extramammary Paget’s Disease of the Axilla Associated with a Benign Mole: A Case Study and a Review of Literature
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Pigmented extramammary Paget’s disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget’s disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget’s cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget’s cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.
Abstract
Pigmented extramammary Paget’s disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget’s disease affecting skin that is rich in apocrine sweat glands such as the axilla, perianal region and vulva. It most commonly occurs in postmenopausal women and presents as a superficial pigmented scaly macule, mimicking a melanocytic lesion. The histological presentation is adenocarcinoma in situ with an increased number of melanocytes scattered between the Paget’s cells. Therefore, PEMPD may be misdiagnosed as a melanocytic tumour both clinically and histologically. The tumour cells are usually positive for cytokeratin 7, epithelial membrane antigen, Cam 5.2, HER2, and mucicarmine stain while S100 and human melanoma black-45 highlight the processes of reactive dendritic cells. The association between Paget’s cells and intratumoural reactive melanocytes is still unclear. We report our first case of PEMPD associated with an intradermal naevus involving the axilla in a 63-year-old woman.
참고문헌 (20)
- Lloyd J, "Mammary and extramammary Paget’s disease", J Clin Pathol, 53, pp.742~749 (2000)
- Petersson F, "Pigmented Paget disease: a diagnostic pitfall mimicking melanoma", Am J Dermatopathol, 31, pp.223~226 (2009)
- Chiba H, "Two cases of vulval pigmented extramammary Paget’s disease: histochemical and immunohistochemical studies", Br J Dermatol, 142, pp.1190~1194 (2000)
- Ko MJ, "Pigmented extramammary Paget’s disease", Dermatol Sin, 22, pp.321~326 (2004)
- Vincent J, "Pigmented extramammary Paget disease of the abdomen: a potential mimicker of melanoma", Dermatol Online J, 17, pp.13~ (2011)
- Hilliard NJ, "Pigmented extramammary Paget’s disease of the axilla mimicking melanoma: case report and review of the literature", J Cutan Pathol, 36, pp.995~1000 (2009)
- Paget J, "On disease of the mammary areola preceding cancer of the mammary gland", St Bartholomew Hosp Rep, 10, pp.87~89 (1874)
- Crocker HR, "Paget’s disease affecting the scrotum and penis", Trans Pathol Soc Lond, 40, pp.187~191 (1889)
- El Khoury M, "Paget’s disease of the axilla arising from an underlying accessory mammary tissue", Clin Radiol, 66, pp.575~577 (2011)
- Chiu CS, "Extramammary Paget’s disease of the unilateral axilla: a review of seven cases in a 20-year experience", Int J Dermatol, 50, pp.157~160 (2011)
- Culberson JD, "Paget’s disease of the nipple: review of twenty-five cases with special reference to melanin pigmentation of Paget cells", AMA Arch Surg, 72, pp.224~231 (1956)
- Azzopardi JG, "Melanocyte colonization and pigmentation of breast carcinoma", Histopathology, 1, pp.21~30 (1977)
- Metcalf JS, "Melanoma: criteria for histological diagnosis and its reporting", Semin Oncol, 23, pp.688~692 (1996)
- Ishizawa T, "Basal cell carcinoma within vulvar Paget’s disease", Dermatology, 197, pp.388~390 (1998)
- Helm KF, "Immunohistochemical stains in extramammary Paget’s disease", Am J Dermatopathol, 14, pp.402~407 (1992)
- Ohno H, "Two cases of unilateral axillary Paget’s disease", J Dermatol, 25, pp.260~263 (1998)
- Goldblum JR, "Vulvar Paget’s disease: a clinicopathologic and immunohistochemical study of 19 cases", Am J Surg Pathol, 21, pp.1178~1187 (1997)
- Zollo JD, "The Roswell Park Cancer Institute experience with extramammary Paget’s disease", Br J Dermatol, 142, pp.59~65 (2000)
- Curtin JP, "Paget’s disease of the vulva", Gynecol Oncol, 39, pp.374~377 (1990)
- Stacy D, "Extramammary Paget’s disease of the vulva and anus: use of intraoperative frozen-section margins", Am J Obstet Gynecol, 155, pp.519~523 (1986)