The Association between Frailty and Cognition in Elderly Women
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Background: Frailty refers to the loss of physiologic complexity and the associated decline in ability to withstandstressors as one gets older. It is defined as unintentional weight loss, exhaustion, weakness, slow walking speed, andlow physical activity. According to several western studies, frailty is associated with cognitive impairment, but therehave been few studies about the relationship between frailty and cognitive impairment in Korea. Thus, the purposeof this study is to analyze the relationship between cognition and factors related to frailty such as grip strength,walking speed, physical activity, and depression, among female patients older than 65 in Korea. Methods: A total of 121 subjects among the outpatients of the department of family medicine at Kangbuk SamsungHospital who did not meet the exclusion criteria were included in this study. We divided the participants into 2groups, according to the Korean version of the Montreal Cognitive Assessment (MoCA) score: 1 group with subjectsthat had normal cognition and the other group with patients that had impaired cognition. A comparison was madebetween the 2 groups in regards to the factors related to frailty, and we completed equation that predicting cognitionfrom the frailty related factors. Results: Compared with the impaired cognition group, the subjects in the normal cognition group had higher handstrength, and walked faster (P<0.001). There was no statistically significant difference in physical activity betweenthe 2 groups (P=0.19). When multiple linear regression analysis was performed using age, grip strength, and walkingspeed as the predictor variables and MoCA score as the dependent variable, the regression coefficients werecalculated to be: -0.2015, 0.2294, 1.2372, and -0.1436, respectively (P<0.05). Conclusion: In Korean female patients who are older than 65 years of age, cognition tends to decline as gripstrength decreases, walking speed gets slower, depression becomes more severe, and as age increases.
Abstract
Background: Frailty refers to the loss of physiologic complexity and the associated decline in ability to withstandstressors as one gets older. It is defined as unintentional weight loss, exhaustion, weakness, slow walking speed, andlow physical activity. According to several western studies, frailty is associated with cognitive impairment, but therehave been few studies about the relationship between frailty and cognitive impairment in Korea. Thus, the purposeof this study is to analyze the relationship between cognition and factors related to frailty such as grip strength,walking speed, physical activity, and depression, among female patients older than 65 in Korea. Methods: A total of 121 subjects among the outpatients of the department of family medicine at Kangbuk SamsungHospital who did not meet the exclusion criteria were included in this study. We divided the participants into 2groups, according to the Korean version of the Montreal Cognitive Assessment (MoCA) score: 1 group with subjectsthat had normal cognition and the other group with patients that had impaired cognition. A comparison was madebetween the 2 groups in regards to the factors related to frailty, and we completed equation that predicting cognitionfrom the frailty related factors. Results: Compared with the impaired cognition group, the subjects in the normal cognition group had higher handstrength, and walked faster (P<0.001). There was no statistically significant difference in physical activity betweenthe 2 groups (P=0.19). When multiple linear regression analysis was performed using age, grip strength, and walkingspeed as the predictor variables and MoCA score as the dependent variable, the regression coefficients werecalculated to be: -0.2015, 0.2294, 1.2372, and -0.1436, respectively (P<0.05). Conclusion: In Korean female patients who are older than 65 years of age, cognition tends to decline as gripstrength decreases, walking speed gets slower, depression becomes more severe, and as age increases.
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