Arterial Stiffness in Patients with Bipolar Disorder
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objective: Bipolar disorder (BD) is an inflammatory and metabolic disease. The disease and the drugs used to treat it may affect cardiovascular disease (CVD) risk. The aim of this study is to investigate arterial stiffness in patients with BD and compare them with healthy controls. Methods: Thirty-nine patients with BD type I in remission and 39 healthy control subjects were included in the study. Carotid and femoral artery intima-media thickness (IMT) and arterial thickness parameters were measured by Doppler ultrasonography. Results: The elastic modulus value of the carotid artery was significantly higher in the patients than in the control group (p = 0.015). Although the IMT of both carotid and femoral artery was thicker in patients than in healthy control subjects, this difference was not statistically significant (p = 0.105; p = 0.391). There was a significant positive correlation between chlorpromazine equivalent dose and femoral elastic modulus value (p = 0.021, r = 0.539). There was a positive correlation between lithium equivalent dose and carotid compliance; a significant negative correlation between lithium equivalent dose and carotid elastic modulus was also determined (both p = 0.007, r = 0.466; p = 0.027, r = −0.391, respectively). No predictor was observed between drug dose and arterial stiffness parameters. Conclusion: Arterial stiffness might be investigated for its potential to reduce CVD risk in patients with BD. Given the established CVD complications in this patient population, further studies are needed to determine whether the results are specific to antipsychotic treatment or BD and to clarify the potential arterial protective effects of mood stabilizers.
Abstract
Objective: Bipolar disorder (BD) is an inflammatory and metabolic disease. The disease and the drugs used to treat it may affect cardiovascular disease (CVD) risk. The aim of this study is to investigate arterial stiffness in patients with BD and compare them with healthy controls. Methods: Thirty-nine patients with BD type I in remission and 39 healthy control subjects were included in the study. Carotid and femoral artery intima-media thickness (IMT) and arterial thickness parameters were measured by Doppler ultrasonography. Results: The elastic modulus value of the carotid artery was significantly higher in the patients than in the control group (p = 0.015). Although the IMT of both carotid and femoral artery was thicker in patients than in healthy control subjects, this difference was not statistically significant (p = 0.105; p = 0.391). There was a significant positive correlation between chlorpromazine equivalent dose and femoral elastic modulus value (p = 0.021, r = 0.539). There was a positive correlation between lithium equivalent dose and carotid compliance; a significant negative correlation between lithium equivalent dose and carotid elastic modulus was also determined (both p = 0.007, r = 0.466; p = 0.027, r = −0.391, respectively). No predictor was observed between drug dose and arterial stiffness parameters. Conclusion: Arterial stiffness might be investigated for its potential to reduce CVD risk in patients with BD. Given the established CVD complications in this patient population, further studies are needed to determine whether the results are specific to antipsychotic treatment or BD and to clarify the potential arterial protective effects of mood stabilizers.
참고문헌 (43)
- Goldstein BI, "Excessive and premature new-onset cardiovascular disease among adults with bipolar disorder in the US NESARC cohort", J Clin Psychiatry, 76, pp.163~169 (2015)
- McIntyre RS, "Bipolar disorders", Lancet, 396, pp.1841~1856 (2020)
- Boutouyrie P, "Arterial stiffness and cardiovascular risk in hypertension", Circ Res, 128, pp.864~886 (2021)
- Teixeira R, "Ultrasonographic vascular mechanics to assess arterial stiffness : A review", Eur Heart J Cardiovasc Imaging, 17, pp.233~246 (2016)
- Zanoli L, "Inflammation and aortic pulse wave velocity : A multicenter longitudinal study in patients with inflammatory bowel disease", J Am Heart Assoc, 8, pp.e010942~ (2019)
- Granata A, "Cardiorenal syndrome type 4 : From chronic kidney disease to cardiovascular impairment", Eur J Intern Med, 30, pp.1~6 (2016)
- Zanoli L, "Pulse wave velocity differs between ulcerative colitis and chronic kidney disease", Eur J Intern Med, 47, pp.36~42 (2018)
- Jenkins ZM, "Arterial stiffness in underweight and weight-restored anorexia nervosa", Psychophysiology, 58, pp.e13913~ (2021)
- Baykara S, "Evaluation of arterial stiffness in patients with schizophrenia", J Clin Neurosci, 79, pp.149~153 (2020)
- Ebru Fındıklı, "Arterial Stiffness in Patients Taking Second-generation Antipsychotics", Clinical Psychopharmacology and Neuroscience, 14(4), pp.365~370 (2016), 대한정신약물학회
- Joly L, "Arterial stiffness and cognitive function", Geriatr Psychol Neuropsychiatr Vieil, 15, pp.83~88 (2017)
- Giridharan VV, "Postmortem evidence of brain inflammatory markers in bipolar disorder : A systematic review", Mol Psychiatry, 25, pp.94~113 (2020)
- Marshe VS, "C-reactive protein and cardiovascular risk in bipolar disorder patients : A systematic review", Prog Neuropsychopharmacol Biol Psychiatry, 79(Pt B), pp.442~451 (2017)
- Pillinger T, "Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology : A systematic review and network meta-analysis", Lancet Psychiatry, 7, pp.64~77 (2020)
- Williams B, "2018 ESC", ESH Guidelines for the management of arterial hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension : The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension, 2018, pp.36, 1953~2041
- Grundy SM, "Diagnosis and management of the metabolic syndrome : An American Heart Association", National Heart, Lung, and Blood Institute Scientific Statement, 2005, pp.112, 2735~2752
- Woods SW, "Chlorpromazine equivalent doses for the newer atypical antipsychotics", J Clin Psychiatry, 64, pp.663~667 (2003)
- Centorrino F, "Combinations of mood-stabilizers with antipsychotics as treatment strategies in hospitalized psychiatric patients", Clin Neuropsychiatry, 3, pp.322~326 (2006)
- Sugino H, "Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharidetreated mice", Prog Neuropsychopharmacol Biol Psychiatry, 33, pp.303~307 (2009)
- Yamamoto S, "Haloperidol suppresses NF-kappaB to inhibit lipopolysaccharide-induced pro-inflammatory response in RAW 264 cells", Med Sci Monit, 22, pp.367~372 (2016)
- Romeo B, "Kinetics of cytokine levels during antipsychotic treatment in schizophrenia : A meta-analysis", Int J Neuropsychopharmacol, 21, pp.828~836 (2018)
- Tourjman V, "Antipsychotics’ effects on blood levels of cytokines in schizophrenia : A meta-analysis", Schizophr Res, 151, pp.43~47 (2013)
- van den Ameele S, "The effect of mood-stabilizing drugs on cytokine levels in bipolar disorder : A systematic review", J Affect Disord, 203, pp.364~373 (2016)
- Sakrajda K, "Inflammation-related changes in mood disorders and the immunomodulatory role of lithium", Int J Mol Sci, 22, pp.1532~ (2021)
- Haacker L, "Endothelial dysfunction and arterial stiffness in patients with bipolar depression", Psychiatry Clin Psychopharmacol, 30, pp.10~16 (2020)
- Yoshimi N, "Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder", BBA Clin, 5, pp.151~158 (2016)
- Shi XF, "Frontal lobe bioenergetic metabolism in depressed adolescents with bipolar disorder : A phosphorus-31 magnetic resonance spectroscopy study", Bipolar Disord, 14, pp.607~617 (2012)
- Kim Y, "Molecular mechanisms of bipolar disorder : Progress made and future challenges", Front Cell Neurosci, 11, pp.30~ (2017)
- Toker L, "Mitochondrial dysfunction in psychiatric morbidity : Current evidence and therapeutic prospects", Neuropsychiatr Dis Treat, 11, pp.2441~2447 (2015)
- François A, "Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice", Mol Brain, 7, pp.56~ (2014)
- Machado-Vieira R, "Decreased AKT1", mTOR pathway mRNA expression in short-term bipolar disorder, 2015, pp.25, 468~473
- Jia J, "Molecular network of neuronal autophagy in the pathophysiology and treatment of depression", Neurosci Bull, 31, pp.427~434 (2015)
- Limanaqi F, "Molecular mechanisms linking ALS", FTD and psychiatric disorders, the potential effects of lithium, 2019, pp.13, 450~
- Prosser JM, "Patients receiving lithium therapy have a reduced prevalence of neurological and cardiovascular disorders", Prog Neuropsychopharmacol Biol Psychiatry, 71, pp.39~44 (2016)
- Fiedorowicz JG, "Vasculopathy related to manic", hypomanic symptom burden and first-generation antipsychotics in a sub-sample from the collaborative depression study, 2012, pp.81, 235~243
- Phillips AA, "Assessment of arterial stiffness among schizophrenia-spectrum disorders using aortic pulse wave velocity and arterial compliance : A pilot study", Psychiatry Res, 215, pp.14~19 (2014)
- Henderson AM, "Greater arterial stiffness in children with or without second-generation antipsychotic treatment for mental health disorders", Can J Psychiatry, 66, pp.667~676 (2021)
- Bosche B, "A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation", Prog Neuropsychopharmacol Biol Psychiatry, 67, pp.98~106 (2016)
- Cho DH, "Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116)signaling cascade in endothelial cells and mice", Free Radic Biol Med, 76, pp.96~106 (2014)
- Newcomer JW, "Second-generation(atypical)antipsychotics and metabolic effects : A comprehensive literature review", CNS Drugs, 19(Suppl 1), pp.1~93 (2005)
- Schmitz SL, "Impact of mood on endothelial function and arterial stiffness in bipolar disorder", Heart Mind(Mumbai), 2, pp.78~84 (2018)
- Gros R, "Extent of vascular remodeling is dependent on the balance between estrogen receptor a and G-protein-coupled estrogen receptor", Hypertension, 68, pp.1225~1235 (2016)
- Ogola BO, "New insights into arterial stiffening: Does sex matter?", J Physiol Heart Circ Physiol, 315, pp.H1073~H1087 (2018)