Studies on Some Bioactive 1,1-Bis(2-benzylidene-5-aryliden-1,3- thiadiazolidin-4-one)cyclopropane
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Some novel heterocyclic derivatives of 1,1-bis(2-phenyl-5-arylidine-1,3-thiadiazolidin-4-one)cyclopropane 4(a-i)have been synthesized from cyclopropane dicarboxylic acid and substituted thiadiazole moieties. All the synthesized compounds have been characterized by elemental and spectral (I.R., ^1H-NMR, Mass) analysis. Furthermore, above said compounds were screened for their antifungal and antibacterial activities. Compound 4c was found the most potent one which further evaluated for lesser toxicity test.
Abstract
Some novel heterocyclic derivatives of 1,1-bis(2-phenyl-5-arylidine-1,3-thiadiazolidin-4-one)cyclopropane 4(a-i)have been synthesized from cyclopropane dicarboxylic acid and substituted thiadiazole moieties. All the synthesized compounds have been characterized by elemental and spectral (I.R., ^1H-NMR, Mass) analysis. Furthermore, above said compounds were screened for their antifungal and antibacterial activities. Compound 4c was found the most potent one which further evaluated for lesser toxicity test.
참고문헌 (26)
- Bloom, B. R., , Nature, 406, pp.759~ (2000)
- Cohen, M. L., , Nature, 406, pp.762~ (2000)
- Almasirad, A., , Bioorg. Med. Chem. Lett, 10, pp.2893~ (2002)
- Foroumadi, A., , Bioorg. Med. Chem. Lett, 16, pp.1164~ (2006)
- Michael, R., , J. Med. Chem, 29, pp.2280~ (1986)
- Schenone, S. S., , Bioorg. Med. Chem, 14, pp.1698~ (2006)
- Clerici, F., , J. Med. Chem, 44, pp.931~ (2001)
- Kaya, A. B., , Pharm. Chem. J, 12, pp.66~ (1978)
- Moshafi, M. H., , J. Serb. Chem. Soc, 76, pp.201~ (2011)
- Tunçbilek, M., , Il Farmaco, 54, pp.475~ (1999)
- Ergene, N., , Il Farmaco, 49, pp.449~ (1994)
- Diurno, M. V., , Il Farmaco, 52, pp.237~ (1997)
- Verma, A., , Eur. J. Med. Chem, 43, pp.897~ (2008)
- Chavan, A. A., , ARKIVOC, pp.148~ (2007)
- Diurno, M. V., , Il Farmaco, 54, pp.579~ (1999)
- Venkatapuram, P., , Chem. Pharm. Bull, 57(6), pp.561~ (2009)
- Cherkupally, S. R., , Org. Commun, 3(3), pp.57~ (2010)
- Dekimpe, N., , Bull. Soc. Chem. Belg, 86, pp.55~ (1977)
- Panwar, H., , Indian J. Chem, 45, pp.2099~ (2006)
- Kumar, A., , Bioorg. Med. Chem, 11, pp.5293~ (2003)
- Czurny, M. R., , Org. Synth, 60, pp.66~ (1975)
- Cruickshank, R., "In Medicinal Microbiology, 12th ed" (1975), Churchill Livingstone
- Collins, A. H., "Microbiological Methods, 2nd ed" (1976), Butterworth
- Khan, Z. K., "In vitro and vivo screening techniques for bioactivity screening and evaluation", In Proceedings of the International Workshop on UNIDO-CDRI (1997)
- Varma, R. S., "Antifungal Agents: Past, Present and Future Prospects" (1998), National Academy of Chemistry and Biology
- Carrol, S. W., , Biometrics, 9, pp.249~ (1952)