Cutaneous UVB Irradiation Alters Gut Microbiota Independently of Skin Inflammation in SKH-1 Hairless Mice
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This study investigates the impact of chronic ultraviolet B (UVB) exposure on gut microbiota composition and skin inflammation. Mice were subjected to a 12-week regimen of low-dose UVB irradiation designed to mimic mild photoaging. Although no significant changes were observed at the phylum level, UVB exposure resulted in a significant decrease in the genus Lactobacillus (P=0.0302) and an increase in Duncaniella (P = 0.046), accompanied by a reduction in α-diversity. At the species level, Lactobacillus johnsonii, a known probiotic, was significantly decreased, while Duncaniella freteri was increased in the UVB-exposed group. Despite these microbial alterations, no significant skin inflammation was detected, as mRNA levels of interleukin (IL)-1β and TNF-α and protein levels of IL1β and IL-2 remained unchanged. These findings suggest that chronic low-dose UVB exposure can alter gut microbial homeostasis independently of local inflammatory responses, highlighting a potential role for the skin-gut axis in mediating systemic effects of environmental UVB exposure.
Abstract
This study investigates the impact of chronic ultraviolet B (UVB) exposure on gut microbiota composition and skin inflammation. Mice were subjected to a 12-week regimen of low-dose UVB irradiation designed to mimic mild photoaging. Although no significant changes were observed at the phylum level, UVB exposure resulted in a significant decrease in the genus Lactobacillus (P=0.0302) and an increase in Duncaniella (P = 0.046), accompanied by a reduction in α-diversity. At the species level, Lactobacillus johnsonii, a known probiotic, was significantly decreased, while Duncaniella freteri was increased in the UVB-exposed group. Despite these microbial alterations, no significant skin inflammation was detected, as mRNA levels of interleukin (IL)-1β and TNF-α and protein levels of IL1β and IL-2 remained unchanged. These findings suggest that chronic low-dose UVB exposure can alter gut microbial homeostasis independently of local inflammatory responses, highlighting a potential role for the skin-gut axis in mediating systemic effects of environmental UVB exposure.