급성 뇌경색 환자의 담낭질환 위험에 대한 후향 코호트 연구
A Retrospective Cohort Study of Risk of Gallbladder Disease in Acute Cerebral Infarction Patients
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Background: Gallbladder diseases after acute cerebral infarction are relatively rare, but could have a serious impact on mortality and morbidity of patients. The purpose of this study was to investigate the risk of gallbladder disease in patients with acute cerebral infarction. Methods: This study analyzed a population-based matched cohort constructed using National Health Insurance Service-Senior cohort dataset in South Korea. Subjects after acute cerebral infarction during 2002-2015 were identified as the exposed group, and up to four individual matched for age, sex, and index years were as the controls. The difference of the risk of gallbladder disease between the exposed and control group was evaluated using Cox regression adjusting for hypertension, diabetes, liver diseases, and the modified Charlson Comorbidity Index (mCCI). The risk of gallbladder disease of the exposed group was evaluated using Cox regression analyses to identify the risk factors. Results: The occurrence of the gallbladder disease was significantly associated with the acute cerebral infarction (p<0.0001). The presence of acute cerebral infarction was associated with a higher risk of gallbladder disease (adjusted hazard ratio=1.44, 95% confidence interval=1.26-1.66). The subjects with higher CCI showed higher risk of gallbladder disease. Among acute cerebral infarction patients, the oldest group, subjects having liver diseases, or subjects with the mCCI higher than two were found significant on the risk of gallbladder disease. Conclusions: Our study showed that the acute cerebral infarction has a significant association with gallbladder disease. These results suggested that the possibility of developing of gallbladder disease in patients with acute cerebral infarction should be considered.
Abstract
Background: Gallbladder diseases after acute cerebral infarction are relatively rare, but could have a serious impact on mortality and morbidity of patients. The purpose of this study was to investigate the risk of gallbladder disease in patients with acute cerebral infarction. Methods: This study analyzed a population-based matched cohort constructed using National Health Insurance Service-Senior cohort dataset in South Korea. Subjects after acute cerebral infarction during 2002-2015 were identified as the exposed group, and up to four individual matched for age, sex, and index years were as the controls. The difference of the risk of gallbladder disease between the exposed and control group was evaluated using Cox regression adjusting for hypertension, diabetes, liver diseases, and the modified Charlson Comorbidity Index (mCCI). The risk of gallbladder disease of the exposed group was evaluated using Cox regression analyses to identify the risk factors. Results: The occurrence of the gallbladder disease was significantly associated with the acute cerebral infarction (p<0.0001). The presence of acute cerebral infarction was associated with a higher risk of gallbladder disease (adjusted hazard ratio=1.44, 95% confidence interval=1.26-1.66). The subjects with higher CCI showed higher risk of gallbladder disease. Among acute cerebral infarction patients, the oldest group, subjects having liver diseases, or subjects with the mCCI higher than two were found significant on the risk of gallbladder disease. Conclusions: Our study showed that the acute cerebral infarction has a significant association with gallbladder disease. These results suggested that the possibility of developing of gallbladder disease in patients with acute cerebral infarction should be considered.
참고문헌 (27)
- Go AS, "Heart disease and stroke statistics--2014 update : a report from the American Heart Association", Circulation, 129, pp.e28~e292 (2014)
- Sacco RL, "An updated definition of stroke for the 21st century : a statement for healthcare professionals from the American Heart Association", American Stroke Association, 2013, pp.44, 2064~2089
- Bonita R, "Epidemiology of stroke", Lancet, 339, pp.342~344 (1992)
- Hong KS, "Stroke statistics in Korea: part I. Epidemiology and risk factors: a report from the Korean Stroke Society and Clinical Research Center for Stroke", J Stroke, 15, pp.2~20 (2013)
- Feigin VL, "Stroke epidemiology : a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century", Lancet Neurol, 2, pp.43~53 (2003)
- Karatepe AG, "Comorbidity in patients after stroke : impact on functional outcome", J Rehabil Med, 40, pp.831~835 (2008)
- Kirchberger I, "Patterns of multimorbidity in the aged population. Results from the KORA-Age study", PLoS One, 7, pp.e30556~ (2012)
- Schäfer I, "The influence of age, gender and socio-economic status on multimorbidity patterns in primary care. First results from the multicare cohort study", BMC Health Serv Res, 12, pp.89~ (2012)
- Shabanzadeh DM, "Incidence of gallstone disease and complications", Curr Opin Gastroenterol, 34, pp.81~89 (2018)
- Yoo MC, "Acute cholecystitis as a rare and overlooked complication in stroke patients : a retrospective monocentric study", Medicine(Baltimore), 98, pp.e14492~ (2019)
- Fukuoka T, "Clinical review of 24 patients with acute cholecystitis after acute cerebral infarction", Intern Med, 53, pp.1321~1323 (2014)
- Kuroi Y, "Acute cholecystitis in patients with stroke", Neurol India, 67, pp.439~441 (2019)
- Charlson ME, "A new method of classifying prognostic comorbidity in longitudinal studies : development and validation", J Chronic Dis, 40, pp.373~383 (1987)
- Quan H, "Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data", Med Care, 43, pp.1130~1139 (2005)
- Heagerty PJ, "Survival model predictive accuracy and ROC curves", Biometrics, 61, pp.92~105 (2005)
- Folsom AR, "Prospective associations of fasting insulin, body fat distribution, and diabetes with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) study investigators", Diabetes Care, 22, pp.1077~1083 (1999)
- Rundek T, "Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study", Arch Neurol, 67, pp.1195~1200 (2010)
- Boden-Albala B, "Metabolic syndrome and ischemic stroke risk : Northern Manhattan Study", Stroke, 39, pp.30~35 (2008)
- Ovbiagele B, "Impact of metabolic syndrome on prognosis of symptomatic intracranial atherostenosis", Neurology, 66, pp.1344~1349 (2006)
- Takada T, "TG13 : updated Tokyo guidelines for the management of acute cholangitis and cholecystitis", J Hepatobiliary Pancreat Sci, 20, pp.1~7 (2013)
- Tana M, "Acute acalculous cholecystitis and cardiovascular disease : a land of confusion", J Ultrasound, 18, pp.317~320 (2015)
- Campbell PT, "Diabetes and cause-specific mortality in a prospective cohort of one million U.S. adults", Diabetes Care, 35, pp.1835~1844 (2012)
- Festi D, "Incidence of gallstone disease in Italy : results from a multicenter, population-based Italian study(the MICOL project)", World J Gastroenterol, 14, pp.5282~5289 (2008)
- González-Pérez A, "Gallbladder disease in the general population : association with cardiovascular morbidity and therapy", Pharmacoepidemiol Drug Saf, 16, pp.524~531 (2007)
- Boland LL, "Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease. A prospective study", Ann Epidemiol, 12, pp.131~140 (2002)
- Chen LY, "Metabolic syndrome and gallstone disease", World J Gastroenterol, 18, pp.4215~4220 (2012)
- Bodmer M, "Statin use and risk of gallstone disease followed by cholecystectomy", JAMA, 302, pp.2001~2007 (2009)