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항암화학요법을 받는 췌장담도암 환자의 삶의 질 영향요인

Factors Influencing the Quality of Life in Pancreatobiliary Cancer Patients Receiving Chemotherapy

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Purpose: The study aim was to investigate factors influencing the quality of life of patients with pancreatobiliary cancer who were receiving chemotherapy. Methods: In this cross-sectional correlational study, participants were 130 patients diagnosed with pancreatobiliary cancer who were receiving chemotherapy at a university-affiliated hospital in South Korea. The data were collected between June 2022 and January 2023. Physical symptoms, perceived health status, anxiety, depression, social support, and quality of life were assessed. Data were analyzed by a hierarchical multiple regression analysis using SPSS 25.0 software. Results: The mean age was 65.15 years, with men comprising 50.8% of the study sample, and the mean disease duration was 5.29 months. Results of the hierarchical regression analysis identified factors influencing the quality of life of the participants: physical symptoms (β=-.35, p<.001), anxiety (β=-.30, p<.001), depression (β=-.19, p=.003), social support (β=.18, p<.001), and perceived health status (β=.13, p=.010). The explanatory power of the final model was 81.0% (F=50.73, p<.001). Conclusion: The holistic and multifaceted efforts of healthcare professionals are recommended to improve the quality of life of patients with pancreatobiliary cancer. Specifically, necessary actions to improve the quality of life of the patients include closely identifying patients’ physical symptoms and perceived health status, assessing and providing early interventions for anxiety and depression, and ensuring social support, including support from family caregivers and healthcare professionals.

Abstract

Purpose: The study aim was to investigate factors influencing the quality of life of patients with pancreatobiliary cancer who were receiving chemotherapy. Methods: In this cross-sectional correlational study, participants were 130 patients diagnosed with pancreatobiliary cancer who were receiving chemotherapy at a university-affiliated hospital in South Korea. The data were collected between June 2022 and January 2023. Physical symptoms, perceived health status, anxiety, depression, social support, and quality of life were assessed. Data were analyzed by a hierarchical multiple regression analysis using SPSS 25.0 software. Results: The mean age was 65.15 years, with men comprising 50.8% of the study sample, and the mean disease duration was 5.29 months. Results of the hierarchical regression analysis identified factors influencing the quality of life of the participants: physical symptoms (β=-.35, p<.001), anxiety (β=-.30, p<.001), depression (β=-.19, p=.003), social support (β=.18, p<.001), and perceived health status (β=.13, p=.010). The explanatory power of the final model was 81.0% (F=50.73, p<.001). Conclusion: The holistic and multifaceted efforts of healthcare professionals are recommended to improve the quality of life of patients with pancreatobiliary cancer. Specifically, necessary actions to improve the quality of life of the patients include closely identifying patients’ physical symptoms and perceived health status, assessing and providing early interventions for anxiety and depression, and ensuring social support, including support from family caregivers and healthcare professionals.

참고문헌 (35)

  1. "Annual report of cancer statistics in Korea in 2010" (2013)[URL]
  2. "Annual report of cancer statistics in Korea in 2020" (2023)[URL]
  3. Shroff RT, "Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers : a phase 2 clinical trial", JAMA Oncology, 5(6), pp.824~830 (2019)[DOI]
  4. Tucker ON, "Controversies in the management of borderline resectable proximal pancreatic adenocarcinoma with vascular involvement", HPB Surgery, 2008, pp.839503~ (2008)[DOI]
  5. Ducreux M, "Cancer of the pancreas : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up", Annals of Oncology, 26(Suppl 5), pp.56~68 (2015)[DOI]
  6. Steel JL, "Clinically meaningful changes in health-related quality of life in patients diagnosed with hepatobiliary carcinoma", Annals of Oncology, 17(2), pp.304~312 (2006)[DOI]
  7. Kim GD, "Symptom cluster in patients with pancreatic cancer", Crisisonomy, 11(11), pp.277~293 (2015)
  8. Lee KH, "Chemotherapy and targeted therapy with management of related complications in pancreatic cancer", The Korean Journal of Pancreas and Biliary Tract, 20(1), pp.5~13 (2015)[DOI]
  9. Jia L, "Investigation of the incidence of pancreatic cancer-related depression and its relationship with the quality of life of patients", Digestion, 82(1), pp.4~9 (2010)[DOI]
  10. Seo JY, "Distress and quality of life in cancer patients receiving chemotherapy", Asian Oncology Nursing, 15(1), pp.18~27 (2015)[DOI]
  11. Fujii H, "Anorexia, pain and peripheral neuropathy are associated with a decrease in quality of life in patients with advanced pancreatic cancer receiving outpatient chemotherapy-a retrospective observational study", Journal of Pharmaceutical Health Care and Sciences, 7(1), pp.1~7 (2021)[DOI]
  12. Lee JS, "Prediction model of the quality of life for patients with pancreatic cancer", Healthcare, 10(10), pp.1973~ (2022)[DOI]
  13. Jun SY, "Structural equation modeling of quality of life in patients with uterine cancer", Korean Journal of Adult Nursing, 32(2), pp.109~123 (2020)[DOI]
  14. Elberg Dengsø K, "Health-related quality of life and anxiety and depression in patients diagnosed with cholangiocarcinoma : a prospective cohort study", Acta Oncologica, 56(2), pp.198~204 (2017)[DOI]
  15. Janda M, "Anxiety, depression and quality of life in people with pancreatic cancer and their carers", Pancreatology, 17(2), pp.321~327 (2017)[DOI]
  16. Barnes AF, "Pancreatic cancer-associated depression : a case report and review of the literature", Pancreas, 47(9), pp.1065~1077 (2018)[DOI]
  17. Grassi L, "Psychiatric and psychosocial implications in cancer care : the agenda of psycho-oncology", Epidemiology and Psychiatric Sciences, 29, pp.e89~ (2020)[DOI]
  18. Kim YJ, "Effects of distress, resilience and social support on pancreatic cancer patients' quality of life", master, pp.2017
  19. Somjaivong B, "The influence of symptoms, social support, uncertainty, and coping on health-related quality of life among cholangiocarcinoma patients in northeast Thailand", Cancer Nursing, 34(6), pp.434~442 (2011)[DOI]
  20. Woo SM, "Effect of early management on pain and depression in patients with pancreatobiliary cancer : a randomized clinical trial", Cancers, 11(1), pp.79~ (2019)[DOI]
  21. Tang CC, "The symptom experience of patients with advanced pancreatic cancer : an integrative review", Cancer Nursing, 41(1), pp.33~44 (2018)[DOI]
  22. Zigmond AS, "The hospital anxiety and depression scale", Acta Psychiatrica Scandinavica, 67(6), pp.361~370 (1983)[DOI]
  23. Oh SM, "A study on the standardization of the hospital anxiety and depression scale for Koreans", Korean Neuropsychiatric Association, 38(2), pp.289~295 (1999)
  24. Zimet GD, "The multidimensional scale of perceived social support", Journal of Personality Assessment, 52(1), pp.30~41 (1988)[DOI]
  25. Shin JS, "The effects of social supports on psychosocial well-being of the unemployed", Korean Journal of Social Welfare, 37, pp.241~269 (1999)
  26. Functional Assessment of Chronic Illness Therapy (FACIT), "The functional assessment of cancer therapy-for patients with hepatobiliary cancer (FACT-Hep) version 4", FACIT Group, ~ (2019)
  27. Woradet S, "Factors affecting health-related quality of life and survival of cholangiocarcinoma patients in northeastern region of Thailand", PLoS One, 11(9), pp.e0163448~ (2016)[DOI]
  28. Cloyd JM, "Impact of pancreatectomy on long-term patient-reported symptoms and quality of life in recurrence-free survivors of pancreatic and periampullary neoplasms", Journal of Surgical Oncology, 115(2), pp.144~150 (2017)[DOI]
  29. Deng Y, "Determinants and prognostic value of quality of life in patients with pancreatic ductal adenocarcinoma", European Journal of Cancer, 92, pp.20~32 (2018)[DOI]
  30. Allen R, "Moving beyond chemotherapy for pancreaticobiliary tumors : targeted and immunotherapy strategies", American Society of Clinical Oncology Educational Book, 40, pp.e333~43 (2020)[DOI]
  31. Mbah N, "Impact of post-operative complications on quality of life after pancreatectomy", Journal of the Pancreas, 13(4), pp.387~393 (2012)[DOI]
  32. Han SS, "Factors that influence quality of life in cancer patients", Korean Journal of Health Promotion, 9(1), pp.33~40 (2009)
  33. Hyun DR, "The Influence of anxiety, uncertainty, and cancer coping on the quality of life in breast cancer patients receiving neoadjuvant chemotherapy", Asian Oncology Nursing, 22(1), pp.37~45 (2022)[DOI]
  34. de la Torre-Luque A, "Psychological treatments to improve quality of life in cancer contexts : a meta-analysis", International Journal of Clinical and Health Psychology, 16(2), pp.211~219 (2016)[DOI]
  35. Jang EH, "A meta-analysis of intervention on depression in cancer patients", Asian Oncology Nursing, 13(1), pp.1~10 (2013)[DOI]

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