눈꺼풀결막에 발생한 로사이 돌프만 병(Rosai-Dorfman Disease) 1예
A Case of Rosai-Dorfman Disease Affecting the Palpebral Conjunctiva
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목적: 드문 질환으로 알려진 눈꺼풀결막에 발생한 로사이 돌프만병(Rosai-Dorfman disease) 1예를 보고하고자 한다. 증례요약: 39세 여자 환자가 3주 전 발생한 양안의 눈꺼풀결막 종괴를 주소로 내원하였다. 환자는 1년 전 림프절염으로 다른 병원에서조직검사 시행 받은 과거력이 있으며, 대퇴부에도 종괴를 호소하였다. 안과 검사에서 다른 이상은 없었으며, 정확한 진단을 위하여절개생검을 시행하였다. 조직병리학 검사상 림프절병을 동반한 동조직구증(sinus histiocytosis with massive lymphadenopathy,SHML) 소견을 보여 로사이 돌프만병에 합당하였으며, S-100 면역 검사상 양성 반응, CD1a 면역 검사상 음성 반응을 보였다. 수술5개월째 창상 부위는 치유된 상태로 재발의 징후는 없었다.
Abstract
Purpose: To report a single case of Rosai-Dorfman disease of the palpebral conjunctiva with a review of the relevant literature. Case summary: A 39-years-old woman presented with a palpebral conjunctival mass 3 weeks in duration on both eyes. The patient had a history of excisional biopsy of lymphadenitis and wanted to remove the mass for cosmetic reasons. An excisional biopsy was performed to obtain a diagnosis for proper management. The histopathologic examination of the lesion showed an intensive proliferation of monotonous and histiocytoid cells beneath the epidermis. Immunohistochemical staining for the S-100 protein was positive and anti-CD1A antibody was negative. Five months after mass excision, there was no evidence of recurrence.
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