백내장 수술 후 스펙트럼영역 빛간섭단층촬영에서 나타나는 신경절세포-내망상층 두께 변화
Thickness in Ganglion Cell-Inner Plexiform Layer on Spectral-Domain Optical Coherence Tomography after Cataract Surgery
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목적: 백내장 수술 전후 스펙트럼영역 빛간섭단층촬영에서 나타나는 신경절세포-내망상층 두께 변화 양상을 알아보고자 하였다. 대상과 방법: 백내장 수술을 받은 33명, 43안을 대상으로 하였다. 백내장 수술 전후로 스펙트럼영역 빛간섭단층촬영을 이용, 시신경유두 주위 망막신경섬유층 두께, 신경절세포-내망상층 두께를 측정하였다. 신호강도, 사분면, 시구역 망막신경섬유층 두께, 구획별 신경절세포-내망상층 두께 등의 자료를 비교 분석하였다. 결과: 백내장 수술 후 신호강도, 망막신경섬유층, 신경절세포-내망상층 두께 모두 증가하는 것으로 조사되었다(p<0.05). 다중회귀분석상 수술 후 신호강도변화에 영향을 주는 인자는 망막신경섬유층의 경우 술 전 내피세포 수, 술 전 신호강도였고, 신경절세포-내망상층의 경우 술 전 신호강도였다. 단변량회귀분석상 수술 후 망막신경섬유층 두께 변화에 영향을 주는 인자는 나이였고, 신경절세포- 내망상층 두께 변화에 영향을 주는 인자는 통계적으로 유의한 결과가 나오지 않았다(p<0.05). 결론: 백내장이 있는 경우 빛간섭단층촬영에 나타나는 수술 전 시신경유두 주위 망막신경섬유층뿐만 아니라 신경절세포-내망상층도두께와 신호강도가 낮게 나타날 수 있어서 결과해석 시 백내장 정도에 의한 영향을 고려하여야 한다.
Abstract
Purpose: To assess changes in ganglion cell-inner plexiform layer (GCIPL) thickness after cataract surgery using spectral-domain optical coherence tomography (OCT). Methods: Forty-three eyes of 33 patients, who underwent cataract surgery were imaged with spectral-domain OCT before and after surgery to measure peripapillary retinal nerve fiber layer (RNFL) and GCIPL thickness, signal strength (SS), quadrant, 12 clock-hour RNFL thickness and sectoral GCIPL thickness. Results: The postoperative SS, RNFL and GCIPL thickness were higher than before surgery (p < 0.05). Multivariate analysis showed that endothelial cell count and preoperative SS were significantly correlated with SS changes in RNFL parameters and preoperative SS was significantly correlated with SS changes in GCIPL parameters. Univariate analysis indicated that age was significantly correlated with RNFL thickness changes in RNFL parameters and no factor was correlated with GCIPL thickness in GCIPL parameters (p < 0.05). Conclusions: Cataracts may decrease peripapillary RNFL and GCIPL thickness measurements and SS on OCT scans. Peripapillary RNFL and GCIPL thickness measurements should be interpreted with caution in eyes with significant cataracts.
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