건성안 진단에서 눈물띠 측정 스트립의 유효성
Efficacy of Strip Meniscometry for Dry Eye Syndrome Diagnosis
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목적: 건성안 환자에서 strip meniscometry를 이용한 눈물 측정치와 기존의 눈물 검사들과의 상관성을 분석하여 strip meniscometry 검사의 진단적 유효성을 평가하고자 한다. 대상과 방법: 연구에 포함된 대상자를 strip meniscometry를 이용한 눈물띠 측정, 쉬르머 검사, 눈물막 파괴시간, 빛간섭단층촬영을이용한 눈물띠 측정 등을 시행한 후 건성안군(n=46안)과 정상안군(n=30안)을 비교분석하였으며, Spearman 상관분석을 이용하여strip meniscometry 측정치와 그 외 검사와의 상관성을 평가하였다. 결과: Strip meniscometry를 이용한 눈물띠 수치는 쉬르머 검사(r=0.6080), 눈물막 파괴시간(r=0.5980), 빛간섭단층촬영을 이용한눈물띠 깊이(r=0.6210), 너비(r=0.6080), 면적(r=0.6370) 수치와 모두 유의한 상관관계를 가졌다(p<0.01). 또한 정상안군(7.07 ± 2.61 mm) 에 비해 건성안군(4.58 ± 1.94 mm)에서 strip meniscometry 측정치가 유의하게 낮았다(p<0.05). 결론: Strip meniscometry는 건성안 환자 및 정상안 환자에서 유의한 차이를 보이며 기존의 눈물 검사와도 유의한 상관관계를 가진다. Strip meniscometry는 쉬르머 검사에 비해 적은 검사시간이 필요하고 비침습적인 방법이므로 건성안 환자의 평가에 유용한 수단이될 수 있을 것으로 기대된다.
Abstract
Purpose: To evaluate the efficacy of strip meniscometry test for dye eye syndrome (DES) by measuring the correlation between strip meniscometry and conventional test measurements. Methods: All subjects were examined using the Schirmer test, tear breakup time (TBUT) and strip meniscometry using SMTube (Echo Electricity Co., Ltd., Fukushima, Japan). Tear meniscus height (TMH), tear meniscus depth (TMD) and tear meniscus area (TMA) were measured using Fourier-domain optical coherence tomography. The DES group (n = 46 eyes) was compared with the normal group (n = 30 eyes) and correlation was assessed using Spearman’s correlation coefficient. Results: Strip meniscometry measurement was significantly correlated with Schirmer score (r = 0.6080, p < 0.01), TBUT (r = 0.5980, p < 0.01), TMH (r = 0.6210, p < 0.01), TMD (r = 0.6080, p < 0.01) and TMA (r = 0.6370, p < 0.01). Strip meniscometry was significantly lower in the DES group (4.58 ± 1.94 mm) than the normal group (7.07 ± 2.61 mm, p < 0.05). Conclusions: Strip meniscometry was significantly correlated with other conventional test measurements for dry eye syndrome. Strip meniscometry is less time consuming and a less invasive method than the Schirmer test. Strip meniscometry could be an efficient tool to evaluate patients with dry eye syndrome in a clinical setting.
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