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플라시도원반 방식의 비디오각막경을 이용한 각막곡률 및 난시측정과 기존의 각막곡률계와의 비교

Measurement of Corneal Power and Astigmatism Using Placido-based Videokeratography and Comparison with Other Keratometers

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목적: 플라시도 원반 방식의 비디오각막경을 이용한 각막곡률 및 난시측정의 임상적 유용성을 평가하고 기존의 각막곡률을 측정할 수 있는 기기들과의 차이가 있는지 알아보고자 하였다. 대상과 방법: 2015년 11월부터 2016년 1월까지 백내장 수술이 예정된 45명 45안을 전향적으로 조사하였다. 플라시도 원반 방식의 비디오각막경(Keratograph® 5M), 자동각막곡률계(KR-8900®), 수동각막곡률계(B&L Manual Ophthalmic Keratometer®), 플라시도원반-세극등주사 각막곡률계(ORBscan II®), 샤임플러그 각막곡률계(Pentacam®) 및 저간섭성 반사계(Lenstar®)를 이용하여 각막곡률 및 난시를 기기당 1안에 3회씩 반복 측정하였다. 기기별 반복성 및 신뢰성 비교는 변동계수, 표준편차 및 군내연관계수를 통해 분석하였고 기기 간 측정치 평균 차이 비교는 반복측정 분산분석을 통해, 일치도 평가는 Bland-Altman plot으로 분석하였다. 결과: 평균각막곡률 및 각막난시의 측정에 있어 Keratograph® 5M과 다른 기기 간의 차이는 없었으며, J0, J45에서도 통계적으로 유의한 차이는 보이지 않았다(p>0.05). Bland-Altman plot으로 분석한 Keratograph® 5M과 다른 기기 간 일치도에서 95% limits of agreement (LoA) 값이 각막곡률은 -0.78~0.55D로, J0은 -0.72~0.88D로, J45는 -0.39~0.47D로 나타났다. 결론: 각막곡률 및 난시의 측정에 있어 Keratograph® 5M은 기존의 각막곡률계와 비교하여 서로 비슷한 재현성을 나타냈으며 다른 기기들과 상호보완적으로 이용될 수 있다.

Abstract

Purpose: In the present study, the repeatability and reproducibility of the corneal power and astigmatism measurements using placido-based video keratography were evaluated and the agreement with other keratometers were compared. Methods: This prospective study included 45 patients (45 eyes) scheduled to undergo cataract surgery between November 2015 and January 2016. Three sets of corneal power and astigmatism were measured using placido-based video keratometer (Keratograph® 5M), automatic keratometer (KR-8900®), manual keratometer (B&L manual keratometer®), Placido-scanning-slit keratometer (ORBscan II®), Scheimpflug keratometer (Pentacam®), and low coherence interferometry (Lenstar LS900®). Reliability of each device was analyzed using the coefficient of variation, standard deviation and intraclass correlation coefficient. Repeated measures analysis of variance was used to analyze the interdevice comparison of mean absolute difference. The agreement between the devices was evaluated with 95% limits of agreement (LoA) and Bland-Altman plots. Results: The mean corneal power, astigmatism and power vector analysis (J0, J45) were not significantly different among devices (p > 0.05). In the Bland-Altman plot analysis, the 95% LoA of corneal power, J0, and J45 when comparing Keratograph® 5M with others ranged from -0.78 to 0.55 D, from -0.42 to 0.45 D, and from –0.39 to 0.47 D, respectively. Conclusions: Keratograph® 5M showed good repeatability and reproducibility of corneal power and astigmatism measurements and was interchangeable with other keratometers.

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