적외선 영상을 이용한 백내장수술 전후 눈물막의 단기 변화의 예비연구
A Pilot Study of Changes in Tear Film Short-term Dynamics with Infrared Imaging after Phacoemulsification
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
목적: 비침습적인 적외선 영상 장비를 이용하여 백내장수술 전후 눈물막의 단기간 변화에 대한 예비연구를 진행하였다. 대상과 방법: 예비연구의 일환으로 건성안을 진단받은 환자를 제외한 17명의 17안을 대상으로 하였다. 수술 전, 수술 후 1일째, 1주일째, 1달째, 총 4차례에 걸쳐 Keratograph를 이용하여 Non-invasive Keratograph tear break-up time (NIK-TBUT; 비침습적 Keratograph 로 측정한 눈물막 파괴시간), Non-invasive Keratograph tear meniscus height (NIK-TMH; 비침습적 Keratograph로 측정한 눈물띠의 높이) 측정을 시행하였다. 결과: 술 전 평균나이는 64.47 ± 10.28세, 여성의 비율은 78.95%를 보였다. 초기 눈물막 파괴시간이 술 후 1일째에는 술 전에 비해 유의하게 감소하지 않았으나, 일주일, 한 달째에 술 전과 비교했을 때 감소하였다(p<0.05). 평균 눈물막 파괴시간과 눈물띠의 높이를 술 전과 비교했을 때 술 후 모든 기간에 유의한 차이가 없었다. 결론: Keratograph를 통해 수술 후에 눈물막 안정성의 감소를 확인할 수 있었다. 세극등 현미경을 이용한 눈물막 평가와의 일치성 및 장기적인 연구 결과가 필요할 것으로 보인다.
Abstract
Purpose: To evaluate the short-term changes in tear film dynamics with non-invasive infrared imaging measurement before and after cataract surgery as a pilot study. Methods: Seventeen eyes of 17 patients without preoperative dry eye were enrolled in this study. Non-invasive keratograph tear break-up time (NIK-TBUT) and non-invasive keratograph tear meniscus height (NIK-TMH) were measured before and 1 day, 1 week, and 1 month after cataract surgery using a keratograph. Results: The mean patient age was 64.47 ± 10.28 years, and 78.95% were female. Although the mean postoperative 1 day NIK-TBUT-first value was not significantly different from the preoperative value, the mean postoperative 1 week and 1 month NIK-TBUT-first values were significantly lower than preoperative values (p < 0.05). The postoperative 1 day, 1 week, and 1 month NIK-TBUT-average and the NIK-TMH values were not different from preoperative values. Conclusions: Our study showed that cataract surgery can lead to tear film instability. And it is important to determine the long-term outcomes of surgery and whether NIK-TBUT and NIK-TMH correlate with slit lamp examination tear break-up time (SLE-TBUT) and slit lamp examination tear meniscus height (SLE-TMH).
참고문헌 (25)
- "The definition and classification of dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop", Ocular surf, 5, pp.75~92 (2007)
- "The epidemiology of dry eye disease: report of the epidemiology subcommittee of the international dry eye workshop", Ocular surf, 5, pp.93~107 (2007)
- Li XM, "Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery", Cornea, 26(9 Suppl 1), pp.S16~S20 (2007)
- Cetinkaya S, "The course of dry eye after phacoemulsification surgery", BMC Ophthalmol, 15, pp.68~ (2015)
- 조양경, "Dry Eye After Cataract Surgeryand Associated Intraoperative Risk Factors", Korean Journal of Ophthalmology, 23(2), pp.65~73 (2009), 대한안과학회
- Kasetsuwan N, "Incidence and pattern of dry eye after cataract surgery", PLoS One, 8, pp.e78657~ (2013)
- Cox SM, "Agreement between automated and traditional measures of tear film breakup", Optom Vis Sci, 92, pp.e257~e263 (2015)
- Lan W, "Automatic noninvasive tear breakup time (TBUT) and conventional fluorescent TBUT", Optom Vis Sci, 91, pp.1412~1418 (2014)
- Yokoi N, "Non-invasive methods of assessing the tear film", Exp Eye Res, 78, pp.399~407 (2004)
- Abdelfattah NS, "Noninvasive imaging of tear film dynamics in eyes with ocular surface disease", Cornea, 34(Suppl 10), pp.S48~S52 (2015)
- Nichols KK, "The repeatability of clinical measurements of dry eye", Cornea, 23, pp.272~285 (2004)
- Dogru M, "Strip meniscometry: a new and simple method of tear meniscus evaluation", Invest Ophthalmol Vis Sci, 47, pp.1895~1901 (2006)
- Altan-Yaycioglu R, "Optical coherence tomography for measuring the tear film meniscus: correlation with schirmer test and tear-film breakup time", Curr Eye Res, 38, pp.736~742 (2013)
- Madden RK, "Comparative study of two non-invasive tear film stability techniques", Curr Eye Res, 13, pp.263~269 (1994)
- Goto T, "Tear film stability analysis system: introducing a new application for videokeratography", Cornea, 23(8 Suppl), pp.S65~S70 (2004)
- Jiang Y, "Noninvasive keratograph assessment of tear film break-up time and location in patients with age-related cataracts and dry eye syndrome", J Int Med Res, 42, pp.494~502 (2014)
- Hong J, "Assessment of tear film stability in dry eye with a newly developed keratograph", Cornea, 32, pp.716~721 (2013)
- Kohlhaas M, "Corneal sensation after cataract and refractive surgery", J Cataract Refract Surg, 24, pp.1399~1409 (1998)
- Ram J, "Outcomes of phacoemulsification in patients with dry eye", J Cataract Refract Surg, 28, pp.1386~1389 (2002)
- Oh T, "Changes in the tear film and ocular surface after cataract surgery", Jpn J Ophthalmol, 56, pp.113~118 (2012)
- Khanal S, "Changes in corneal sensitivity and tear physiology after phacoemulsification", Ophthalmic Physiol Opt, 28, pp.127~134 (2008)
- "Methodologies to diagnose and monitor dry eye disease: report of the definition and classification subcommittee of the international dry eye workshop", Ocular Surf, 5, pp.108~152 (2007)
- Kojima T, "A new noninvasive tear stability analysis system for the assessment of dry eyes", Invest Ophthalmol Vis Sci, 45, pp.1369~1374 (2004)
- Mengher LS, "Effect of fluorescein instillation on the pre-corneal tear film stability", Curr Eye Res, 4, pp.9~12 (1985)
- Hertzog MA, "Considerations in determining sample size for pilot studies", Res Nurs Health, 31, pp.180~191 (2008)